Breaking time-reversal symmetry with a superconducting flux capacitor

We present the design of a passive, on-chip microwave circulator based on a ring of superconducting tunnel junctions. We investigate two distinct physical realisations, based on either Josephson junctions (JJ) or quantum phase slip elements (QPS), with microwave ports coupled either capacitively (JJ) or inductively (QPS) to the ring structure. A constant bias applied to the center of the ring provides the symmetry breaking (effective) magnetic field, and no microwave or rf bias is required. We find that this design offers high isolation even when taking into account fabrication imperfections and environmentally induced bias perturbations and find a bandwidth in excess of 500 MHz for realistic device parameters.Comment: 10 pages, 11 figures, including supplementary material - published as "Passive on-chip, superconducting circulator using rings of tunnel junctions

The Political Economy of Mass Printing: Legitimacy and Technological Change in the Ottoman Empire

New technologies have not always been greeted with full enthusiasm. Although the Ottomans were quick to adopt advancements in military technology, they waited almost three centuries to sanction printing in Ottoman Turkish (in Arabic characters). Printing spread relatively rapidly throughout Europe following the invention of the printing press in 1450 despite resistance by interest groups and temporary restrictions in some countries. We explain differential reaction to technology through a political economy approach centered on the legitimizing relationships between rulers and their agents (e.g., military, religious, or secular authorities). The Ottomans regulated the printing press heavily to prevent the loss it would have caused to the ruler’s net revenue by undermining the legitimacy provided by religious authorities. On the other hand, the legitimizing relationship between European religious and political authorities was undermined over a century prior to the invention of the press. European rulers thus had little reason to stop the spread of printing as public policy, nor could the Church have stopped it had it wanted to. The Ottomans eventually sanctioned printing in Arabic script in the 18th century after alternative sources of legitimacy emerged

Periodontal-Systemic Disease Education in United States Dental Hygiene Programs

The relationship between periodontal disease and systemic disease has gained much attention in recent years in the dental profession and from national health care agencies. Two third-party providers are now modifying their dental reimbursements for patients who have periodontal disease and are pregnant or have cardiovascular disease. However, there are few reports in the dental or dental hygiene literature about how students are taught this information and how it is incorporated into the didactic and clinical aspects of the curriculum. A thirty-item survey and cover letter on these subjects were emailed to the directors of the 286 accredited dental hygiene programs in the United States in 2007. The response rate was 63 percent. According to these responses, the three most emphasized topics regarding oral-systemic disease are diabetes, tobacco use, and cardiovascular disease. Most programs (90 percent) use journal articles for instructional content, and 87 percent use the American Academy of Periodontology website for reference. Only 4 percent have content taught jointly with nursing, medical, or allied health students. The majority of directors (87 percent) indicated they could use more evidence-based educational materials to help teach the concepts to students. Only 9 percent of survey respondents thought that nurses and physicians are knowledgeable about the relationship of oral health to systemic disease. The findings indicate that dental hygiene program directors are confident about the education on oral-systemic content provided to their dental hygiene students, but would like additional evidence-based materials to help their students learn this topic

Political Legitimacy and Technology Adoption

A fundamental question of economic and technological history is why some civilizations adopted new and important technologies and others did not. In this paper, we analyze the effect that new technologies have on agents that legitimize rulers. We construct a simple political economy model which suggests that rulers may not accept a productivity-enhancing technology when it negatively affects an agent’s ability to provide the ruler legitimacy. However, when other sources of legitimacy emerge, the ruler will accept the technology as long as the new legitimizing source is not negatively affected. We use this insight to help explain the initial blocking but eventual accepting of the printing press in the Ottoman Empire and industrialization in Tsarist Russia.tef

Growth, Condition, and Trophic Relations of Stocked Trout in Southern Appalachian Mountain Streams

Stream trout fisheries are among the most popular and valuable in the United States, but many are dependent on hatcheries to sustain fishing and harvest. Thus, understanding the ecology of hatchery‐reared trout stocked in natural environments is fundamental to management. We evaluated the growth, condition, and trophic relations of Brook Trout Salvelinus fontinalis, Brown Trout Salmo trutta, and Rainbow Trout Oncorhynchus mykiss that were stocked in southern Appalachian Mountain streams in western North Carolina. Stocked and wild (naturalized) trout were sampled over time (monthly; September 2012–June 2013) to compare condition and diet composition and to evaluate temporal dynamics of trophic position with stable isotope analysis. Relative weights (Wr) of stocked trout were inversely associated with their stream residence time but were consistently higher than those of wild trout. Weight loss of harvested stocked trout was similar among species and sizes, but fish stocked earlier lost more weight. Overall, 40% of 141 stomachs from stocked trout were empty compared to 15% of wild trout stomachs (N = 26). We identified a much higher rate of piscivory in wild trout (18 times that of stocked trout), and wild trout were 4.3 times more likely to consume gastropods relative to stocked trout. Hatchery‐reared trout were isotopically similar to co‐occurring wild fish for both δ13C and δ15N values but were less variable than wild trout. Differences in sulfur isotope ratios (δ34S) between wild and hatchery‐reared trout indicated that the diets of wild fish were enriched in δ34S relative to the diets of hatchery‐reared fish. Although hatcheryreared trout consumed prey items similar to those of wild fish, differences in consumption or behavior (e.g., reduced feeding) may have resulted in lower condition and negative growth. These findings provide critical insight on the trophic dynamics of stocked trout and may assist in developing and enhancing stream trout fisheries

Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations

Recognition of DNA by proteins depends on DNA sequence and structure. Often unanswered is whether the structure of naked DNA persists in a protein–DNA complex, or whether protein binding changes DNA shape. While X-ray structures of protein–DNA complexes are numerous, the structure of naked cognate DNA is seldom available experimentally. We present here an experimental and computational analysis pipeline that uses hydroxyl radical cleavage to map, at single-nucleotide resolution, DNA minor groove width, a recognition feature widely exploited by proteins. For 11 protein–DNA complexes, we compared experimental maps of naked DNA minor groove width with minor groove width measured from X-ray co-crystal structures. Seven sites had similar minor groove widths as naked DNA and when bound to protein. For four sites, part of the DNA in the complex had the same structure as naked DNA, and part changed structure upon protein binding. We compared the experimental map with minor groove patterns of DNA predicted by two computational approaches, DNAshape and ORChID2, and found good but not perfect concordance with both. This experimental approach will be useful in mapping structures of DNA sequences for which high-resolution structural data are unavailable. This approach allows probing of protein family-dependent readout mechanisms.National Institutes of Health [R01GM106056 to R.R., T.D.T.; U54CA121852 in part to T.D.T.]; Boston University Undergraduate Research Opportunities Program [Faculty Matching Grants to D.O. and Y.J.]; USC Graduate School [Research Enhancement Fellowship and Manning Endowed Fellowship to T.P.C.]. R.R. is an Alfred P. Sloan Research Fellow. Funding for open access charge: Boston University. (R01GM106056 - National Institutes of Health; U54CA121852 - National Institutes of Health; Boston University Undergraduate Research Opportunities Program; USC Graduate School; Boston University)https://academic.oup.com/nar/article/46/5/2636/4829691?searchresult=1https://academic.oup.com/nar/article/46/5/2636/4829691?searchresult=1Published versio

A transcriptome map of cellular transformation by the fos oncogene

BACKGROUND: The c-fos gene was originally identified as the cellular homolog of the oncogene v-fos carried by the Finkel-Biskis-Jenkins and Finkel-Biskis-Reilly murine osteogenic sarcoma retroviruses. Sustained expression of fos is sufficient to induce cellular transformation in vitro and tumorigenesis in vivo. Fos functions as a component of the AP-1 transcription factor complex to regulate gene transcription and several differentially expressed genes have been identified in cells transformed by fos. We have extended these studies by constructing a cellular system for conditional transformation by v-fos. Using Affymetrix-based DNA microarray technology, we analyzed transcriptional changes over the course of transformation and reversion in an inducible v-fos system. RESULTS: Microarray analyses of temporal gene expression during the process of v-fos mediated cellular transformation and morphological reversion revealed a remarkably dynamic transcriptome. Of the more than 8000 genes analyzed in this study, 3766 genes were categorized into 18 gene-expression patterns by using self-organizing map analysis. By combining the analysis of gene expression profiles in stably transformed cells with the analysis of sequential expression patterns during conditional transformation, we identified a relatively small cohort of genes implicated in v-fos mediated cellular transformation. CONCLUSION: This approach defines a general conditional cell transformation system that can be used to study the endogenous transcription regulatory mechanisms involved in transformation and tumorigenesis. In addition, this study is the first reported analysis of dynamic changes in gene expression throughout experimentally controlled morphological transformation mediated by v-fos

Control of the Scattering Properties of Complex Systems By Means of Tunable Metasurfaces

We demonstrate the ability to control the scattering properties of a two-dimensional wave-chaotic microwave billiard through the use of tunable metasurfaces located on the interior walls of the billiard. The complex reflection coefficient of the metasurfaces can be varied by applying a DC voltage bias to varactor diodes on mushroom-shaped resonant patches, and this proves to be very effective at perturbing the eigenmodes of the cavity. Placing multiple metasurfaces inside the cavity allows us to engineer desired scattering conditions, such as coherent perfect absorption (CPA), by actively manipulating the poles and zeros of the scattering matrix through the application of multiple voltage biases. We demonstrate the ability to create on-demand CPA conditions at a specific frequency, and document the near-null of output power as a function of four independent parameters tuned through the CPA point. A remarkably low output-to-input power ratio of $\frac{P_{out}}{P_{in}} = 3.71 \times 10^{-8}$ is achieved near the CPA point at 8.54 GHz

HLHS is caused by the up regulation of HIF1α due to hypoxia caused by a polymorphism in eNOS

Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect occurring in fewer than 0.5% of live births in the United States (Fruitman, 2000). It is characterized by a critically underdeveloped left ventricle with accompanying imperfections including septal defects, under-sized aorta, and underdeveloped bicuspid and aortic semilunar valves (Mayo Clinic Staff, 2012; CDC, 2013). HLHS is detectable on ultrasound at the end of the first trimester of pregnancy allowing for early diagnosis and potential treatment in utero. While a protocol involving three surgeries exists to treat the condition, there is no cure for HLHS. Even with treatment, many patients eventually require a heart transplant due to congestive heart failure

PREDOMINANTLY LOW METALLICITIES MEASURED IN A STRATIFIED SAMPLE OF LYMAN LIMIT SYSTEMS AT Z = 3.7

We measured metallicities for 33 z = 3.4–4.2 absorption line systems drawn from a sample of H i-selected-Lyman limit systems (LLSs) identified in Sloan Digital Sky Survey (SDSS) quasar spectra and stratified based on metal line features. We obtained higher-resolution spectra with the Keck Echellette Spectrograph and Imager, selecting targets according to our stratification scheme in an effort to fully sample the LLS population metallicity distribution. We established a plausible range of H i column densities and measured column densities (or limits) for ions of carbon, silicon, and aluminum, finding ionization-corrected metallicities or upper limits. Interestingly, our ionization models were better constrained with enhanced α-to-aluminum abundances, with a median abundance ratio of [α/Al] = 0.3. Measured metallicities were generally low, ranging from [M/H] = −3 to −1.68, with even lower metallicities likely for some systems with upper limits. Using survival statistics to incorporate limits, we constructed the cumulative distribution function (CDF) for LLS metallicities. Recent models of galaxy evolution propose that galaxies replenish their gas from the low-metallicity intergalactic medium (IGM) via high-density H i "flows" and eject enriched interstellar gas via outflows. Thus, there has been some expectation that LLSs at the peak of cosmic star formation (z ≈ 3) might have a bimodal metallicity distribution. We modeled our CDF as a mix of two Gaussian distributions, one reflecting the metallicity of the IGM and the other representative of the interstellar medium of star-forming galaxies. This bimodal distribution yielded a poor fit. A single Gaussian distribution better represented the sample with a low mean metallicity of [M/H] ≈ −2.5.Massachusetts Institute of Technology. Undergraduate Research Opportunities ProgramNational Science Foundation (U.S.) (Award AST-1109915