An Observational study on Siddha Diagnostic Tools including Line of treatment and Dietary Regimen of Kabaala Karappan

Initially the author had selected 4-5 topics. The author was interested to select this topics because now a days most of the people with seborrheic dermatitis are developing more complications, So the author show this topic to a modern pathologist, She gave more information to the author about the disease. Then this topic is submitted to the screening committe members and got approved from IEC committe members. The aim of this study is to evaluate the significance of the disease kabaala karappan with help of siddha parameters Ennvagai thervu, manikadai nool and yaakkaiElakkanam. Kabaala karappan is quoted in the Yugi Vaithiya Chinthamani-800.It is one of the karappan disease characterized by itching of scalp, ear, flaky scaly, dandruff, running nose, sneezing. The author had collected review of literature, definition, etiology and classification regarding the disease from various books. From the observational study, In O.P.D 100 cases were observed as per the inclusion and exclusion criteria and the informed consent were observed from the patients. Case sheet proforma were maintained for 100 cases author took the study in her OPD under the guidance of her department faculty. Laboratory investigations also were carried out during the study. Ennvagai Thaervu, yaakkai Elakkanam, manikkadai nool, and panja patchi saasthiram were focused in the study. In this study, following data were observed and discussed for the 100 cases. Among 100 cases, 100% of cases presented with itching in head, 97% scaling in head, 29% of cases itching in ear, 27% sneezing, 88%had mithaveppam, 57% had vadha pitham, 38% had neikkuri of vadhapitham. 52% had pithavadham thegi. 47%had 8 3/4 fbs in manikkadainool, 44% had vaayu (air) element

Alternate Servers with Set up Times

The paper analyzes a queueing model consisting of a single queue serviced by two servers alternately. A change over time is required when one server is replaced by another. In a busy period, only one server is servicing and when it empties the queue, the second server takes over and thus the two servers work alternately. The actual service after the change over time of the particular server under operation

Cavitation descaling techniques for geothermal applications

A simple and more efficient technique for descaling hard silica scales is urgently needed in order to exploit geothermal energy resources economically. With this objective in mind, DAEDALEAN ASSOCIATES, Incorporated is engaged in a research and development program utilizing the phenomenon of cavitation for cleaning and descaling under the sponsorship of ERDA, Division of Geothermal Research. The highlights of the research carried out so far under this program is reviewed in this presentation. Various effects of the phenomenon of cavitation erosion are presented. The intensity of cavitation erosion and its use in descaling applications are explained. The parameters governing the intensity of erosion are discussed. The overall objectives of the program are to demonstrate the engineering feasibility of utilizing cavitation and to generate engineering design data for its application in geothermal technology. The test facility used for this research consists of flow equipment, test chamber, and associated instrumentation. The performance of cavitating nozzles have been evaluated over a range of sizes. The intensity of erosion for one specific nozzle has been measured. The cleaning rates, the quality of cleaned surface and the intensity margin available so as not to damage the pipe wall have been determined for this specific design. Further work is under progress

Cell-mediated immunity in chyluria

Cellular immune response to mitogens phytohemaggluthin (PHA) and poke weed mitogen (PWM) was assessed in 13 patients with chyluria and 32 healthy controls. The mean stimulation Index of the patient group was significantly lower than the control group. The degree of depression was neither related to the duration of excretion of chyle nor to the microfilaraemic status

Delftia acidovorans: A Rare Pathogen Isolated from Pleural Fluid in an Immunocompromised Host

Delftia acidovorans is an aerobic, non fermentative gram negative rod that belongs to the Pseudomonas ribosomal Ribonucleic Acid (rRNA) homology Group III. The sources of isolation are sludge, biological waste water treatment plants. Patients in hospitals or with compromised immune systems are more likely to be affected. Delftia acidovorans can result in infectious endocarditis, ocular infections, otitis media, peritonitis, urinary tract infections, empyema, cavitary and interstitial pneumoniae, and nosocomial bacteraemia, including bacteraemia linked to central venous catheters in people with compromised immune systems. This case report is about a 57-year-old male with complaints of loss of appetite for six days and vomiting, as well as loss of weight. He was diagnosed with HIV two years ago and was on HAART (Highly Active Antiretroviral Therapy). This atypical bacterium was isolated from pleural fluid of the patient; and he was managed with albumin infusion, anticoagulants, beta blockers, fluid and salt restriction and intravenous antibiotics. It is an emerging source of Gram negative bacilli which is normally a non pathogen causing serious infections among immunocompromised patient

Outage Performance of Bidirectional Full-Duplex Amplify-and-Forward Relay Network with Transmit Antenna Selection and Maximal Ratio Combining, Journal of Telecommunications and Information Technology, 2018, nr 1

In this paper, a bidirectional full-duplex amplify- and-forward (AF) relay network with multiple antennas at source nodes is proposed. Assuming that the channel state information is known at the source nodes, transmit antenna selection and maximal ratio combining (MRC) are employed when source nodes transmit information to the relay node and receive information from the relay node respectively, in order to improve the overall signal-to-interference plus noise ratio (SINR). Analytical expressions are derived for tight upper bound SINR at the relay node and source nodes upon reception. Further, losed form expressions are also derived for end-to-end outage probability of the proposed bidirectional full-duplex AF relay network in the Nakagami-m fading channel environment. Although self-interference at the relay node limits the performance of the full-duplex network, the outage performance of the proposed network is better than that of conventional bidirectional full-duplex and half-duplex AF relay networks, due to the selection diversity gain in TAS and diversity and array gain in MRC

Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

The aberrant epigenetic silencing of tumor suppressor genes (TSGs) plays a major role during carcinogenesis and regaining these dormant functions by engineering of sequence-specific epigenome editing tools offers a unique opportunity for targeted therapies. However, effectively normalizing the expression and regaining tumor suppressive functions of silenced TSGs by artificial transcription factors (ATFs) still remains a major challenge. Herein we describe novel combinatorial strategies for the potent reactivation of two class II TSGs, MASPIN and REPRIMO, in cell lines with varying epigenetic states, using the CRISPR/dCas9 associated system linked to a panel of effector domains (VP64, p300, VPR and SAM complex), as well as with protein-based ATFs, Zinc Fingers and TALEs. We found that co-delivery of multiple effector domains using a combination of CRISPR/dCas9 and TALEs or SAM complex maximized activation in highly methylated promoters. In particular, CRISPR/dCas9 VPR with SAM upregulated MASPIN mRNA (22,145-fold change) in H157 lung cancer cells, with accompanying re-expression of MASPIN protein, which led to a concomitant inhibition of cell proliferation and induction of apoptotic cell death. Consistently, CRISPR/dCas9 VP64 with SAM upregulated REPRIMO (680-fold change), which led to phenotypic reprogramming in AGS gastric cancer cells. Altogether, our results outlined novel sequence-specific, combinatorial epigenome editing approaches to reactivate highly methylated TSGs as a promising therapy for cancer and other diseases

Acute tropical pulmonary eosinophilia: characterization of the lower respiratory tract inflammation and its response to therapy

Although acute tropical pulmonary eosinophilia (TPE) is well recognized as a manifestation of filarial infection, the processes that mediate the abnormalities of the lung in TPE are unknown. To evaluate the hypothesis that the derangements of the lower respiratory tract in this disorder are mediated by inflammatory cells in the local milieu we utilized bronchoalveolar lavage to evaluate affected individuals before and after therapy. Inflaminatory cells recovered from the lower respiratory tract of individuals with acute, untreated TPE (a = 8) revealed a striking eosinophilic alveolitis, with marked elevations in both the proportion of eosinophils (TPE 54±5%; normal 2±5%; P < 0.001) and the concentration of eosinophils in the recovered epithelial lining fluid (ELF) (TPE 63±20 X 103/Al; normal 03±0.1 X 103/jl; P < 0.01). Importantly, when individuals (a = 5) with acute TPE were treated with diethylcarbamazine (DEC), there was a marked decrease of the lung eosinophils and concomitant increase in lung function. These observations are consistent with the concept that at least some of the abnormalities found in the lung in acute TPE are mediated by an eosinophil-dominated inflammatory process in the lower respiratory tract

An influence of dew point temperature on the occurrence of Mycobacterium tuberculosis disease in Chennai, India.

Climate factors such as dew point temperature, relative humidity and atmospheric temperature may be crucial for the spread of tuberculosis. This study was conducted for the first time to investigate the relationship of climatic factors with TB occurrence in an Indian setting. Daily tuberculosis notification data during 2008-2015 were generated from the National Treatment Elimination Program, and analogous daily climatic data were obtained from the Regional Meteorological Centre at Chennai city, Tamil Nadu, India. The decomposition method was adopted to split the series into deterministic and non-deterministic components, such as seasonal, non-seasonal, trend and cyclical, and non-deterministic climate factors. A generalized linear model was used to assess the relation independently. TB disease progression from latent stage infection to active was supported by higher dew point temperature and moderate temperature. It had a significant association with TB progression in the summer and monsoon seasons. The relative humidity may be favored in the winter and post-monsoon. The water tiny dew droplets may support the TB bacterium to recuperate in the environment