On the Representation Theory of an Algebra of Braids and Ties

We consider the algebra ${\cal E}_n(u)$ introduced by F. Aicardi and J. Juyumaya as an abstraction of the Yokonuma-Hecke algebra. We construct a tensor space representation for ${\cal E}_n(u)$ and show that this is faithful. We use it to give a basis for ${\cal E}_n(u)$ and to classify its irreducible representations.Comment: 24 pages. Final version. To appear in Journal of Algebraic Combinatorics

The Efficiency of Grain Alignment in Dense Interstellar Clouds: A Reassessment of Constraints from Near Infrared Polarization

A detailed study of interstellar polarization efficiency toward molecular clouds is used to attempt discrimination between grain alignment mechanisms in dense regions of the ISM. Background field stars are used to probe polarization efficiency in quiescent regions of dark clouds, yielding a dependence on visual extinction well-represented by a power law. No significant change in this behavior is observed in the transition region between the diffuse outer layers and dense inner regions of clouds, where icy mantles are formed, and we conclude that mantle formation has little or no effect on the efficiency of grain alignment. Young stellar objects generally exhibit greater polarization efficiency compared with field stars at comparable extinctions, displaying enhancements by factors of up to 6. Of the proposed alignment mechanisms, that based on radiative torques appears best able to explain the data. The attenuated external radiation field accounts for the observed polarization in quiescent regions, and radiation from the embedded stars themselves may enhance alignment in the lines of sight to YSOs. Enhancements in polarization efficiency observed in the ice features toward several YSOs are of greatest significance, as they demonstrate efficient alignment in cold molecular clouds associated with star formation

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-beta signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;mu MT-/- compound mutant mice, but fibrosis still occurred in their Smad3-/- counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1a1 gene transcription independently of canonical TGF-beta/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis

Self-Organization of the Escherichia coli Chemotaxis Network Imaged with Super-Resolution Light Microscopy

Photoactivated localization microscopy analysis of chemotaxis receptors in bacteria suggests that the non-random organization of these proteins results from random self-assembly of clusters without direct cytoskeletal involvement or active transport

Adubação orgânica e cultivar na curva de produtividade de erva-mate para quatro colheitas.

Tradicionalmente os plantios de erva-mate no Brasil são efetuados por mudas propagadas por semente, proporcionando heterogeneidade nos ervais. A nutrição, apesar de ser uma tecnologia importante para a manutenção ou melhoria da produtividade é pouco utilizada. Quando a nutrição é realizada, normalmente é feita com fontes minerais de nutrientes. Para culturas perenes, como a erva-mate, a adubação orgânica que apresenta liberação lenta de nutrientes pode ser uma boa opção, porém pouco se conhece ao seu respeito. O objetivo do estudo foi avaliar ao longo de quatro colheitas, doses de composto orgânico e cultivares na produtividade da erva-mate. O experimento foi instalado em setembro de 2016, em Canoinhas, SC, no espaçamento 1,60 x 2,75 m. Os tratamentos foram arranjados no fatorial 3 x 2 em esquema de parcela subdividida, com três doses de adubo orgânico (Dose 1= zero, Dose 2= dose recomendada e Dose 3= dose 75 % acima da recomendada) e duas cultivares de erva-mate (BRS 408 e BRS 409), sendo a parcela constituída pela dose do adubo orgânico e a subparcela pela cultivar. Cada unidade experimental foi composta por cinco plantas úteis, com duas linhas de bordadura. Os tratamentos foram dispostos no delineamento blocos casualizados, com quatro repetições. A primeira colheita foi efetuada no intervalo de 2,0 anos e, as demais, com 1,5 anos. Avaliou-se a massa de folha (FO), galho fino (GF) e erva-mate comercial (ECOM= FO+GF). Todas as variáveis avaliadas foram influenciadas significativamente pela idade do erval e dose de cama de frango. Somente a produtividade de GF foi influenciada pela interação entre idade do erval, dose de cama de frango e cultivar. A produtividade de FO e ECOM foi afetada pela interação entre idade do erval e dose de cama de frango. A produtividade de todos os componentes avaliados aumentou de forma exponencial em função da idade do plantio. A maior produtividade, de todos os componentes avaliados, ocorreu na Dose 3 e, a menor, na Dose 1. A produtividade de folha, galho fino e erva-mate comercial apresenta comportamento exponencial nas primeiras quatro colheitas pós plantio. Conclui-se que a cultivar BRS 409 se destaca na produtividade de galho fino, mas isso não afeta a massa de ECOM, pois, as duas cultivares são semelhantes. A adubação orgânica é uma boa fonte de nutriente para a cultura da erva-mate. Para atender a demanda nutricional de nitrogênio, fósforo e potássio da fase inicial, quando se usa fontes orgânicas, a dose desses nutrientes deve ser maior que a indicada para fontes minerais

MRI Findings for Frozen Shoulder Evaluation: Is the Thickness of the Coracohumeral Ligament a Valuable Diagnostic Tool?

Recent studies have demonstrated that the coracohumeral ligament (CHL) is shortened and thickened in a frozen shoulder. We analyzed the rate in CHL visualization between patients with frozen shoulder and normal volunteers using Magnetic Resonance Imaging (MRI) to determine the CHL thickness in the patients with a frozen shoulder.>0.05).MR Imaging is a satisfactory method for CHL depiction, and a thickened CHL is highly suggestive of frozen shoulder

Reading the biomineralized book of life: expanding otolith biogeochemical research and applications for fisheries and ecosystem-based management

Chemical analysis of calcified structures continues to flourish, as analytical and technological advances enable researchers to tap into trace elements and isotopes taken up in otoliths and other archival tissues at ever greater resolution. Increasingly, these tracers are applied to refine age estimation and interpretation, and to chronicle responses to environmental stressors, linking these to ecological, physiological, and life-history processes. Here, we review emerging approaches and innovative research directions in otolith chemistry, as well as in the chemistry of other archival tissues, outlining their value for fisheries and ecosystem-based management, turning the spotlight on areas where such biomarkers can support decision making. We summarise recent milestones and the challenges that lie ahead to using otoliths and archival tissues as biomarkers, grouped into seven, rapidly expanding and application-oriented research areas that apply chemical analysis in a variety of contexts, namely: (1) supporting fish age estimation; (2) evaluating environmental stress, ecophysiology and individual performance; (3) confirming seafood provenance; (4) resolving connectivity and movement pathways; (5) characterising food webs and trophic interactions; (6) reconstructing reproductive life histories; and (7) tracing stock enhancement efforts. Emerging research directions that apply hard part chemistry to combat seafood fraud, quantify past food webs, as well as to reconcile growth, movement, thermal, metabolic, stress and reproductive life-histories provide opportunities to examine how harvesting and global change impact fish health and fisheries productivity. Ultimately, improved appreciation of the many practical benefits of archival tissue chemistry to fisheries and ecosystem-based management will support their increased implementation into routine monitoring.[GRAPHICS]

The State-of-Play of Anomalous Microwave Emission (AME) Research

Anomalous Microwave Emission (AME) is a component of diffuse Galactic radiation observed at frequencies in the range $\approx 10$-60 GHz. AME was first detected in 1996 and recognised as an additional component of emission in 1997. Since then, AME has been observed by a range of experiments and in a variety of environments. AME is spatially correlated with far-IR thermal dust emission but cannot be explained by synchrotron or free-free emission mechanisms, and is far in excess of the emission contributed by thermal dust emission with the power-law opacity consistent with the observed emission at sub-mm wavelengths. Polarization observations have shown that AME is very weakly polarized ($\lesssim 1$%). The most natural explanation for AME is rotational emission from ultra-small dust grains ("spinning dust"), first postulated in 1957. Magnetic dipole radiation from thermal fluctuations in the magnetization of magnetic grain materials may also be contributing to the AME, particularly at higher frequencies ($\gtrsim 50$ GHz). AME is also an important foreground for Cosmic Microwave Background analyses. This paper presents a review and the current state-of-play in AME research, which was discussed in an AME workshop held at ESTEC, The Netherlands, June 2016.Comment: Accepted for publication in New Astronomy Reviews. Summary of AME workshop held at ESTEC, The Netherlands, June 2016, 40 pages, 18 figures. Updated to approximately match published versio

Robust Signal Processing in Living Cells

Cellular signaling networks have evolved an astonishing ability to function reliably and with high fidelity in uncertain environments. A crucial prerequisite for the high precision exhibited by many signaling circuits is their ability to keep the concentrations of active signaling compounds within tightly defined bounds, despite strong stochastic fluctuations in copy numbers and other detrimental influences. Based on a simple mathematical formalism, we identify topological organizing principles that facilitate such robust control of intracellular concentrations in the face of multifarious perturbations. Our framework allows us to judge whether a multiple-input-multiple-output reaction network is robust against large perturbations of network parameters and enables the predictive design of perfectly robust synthetic network architectures. Utilizing the Escherichia coli chemotaxis pathway as a hallmark example, we provide experimental evidence that our framework indeed allows us to unravel the topological organization of robust signaling. We demonstrate that the specific organization of the pathway allows the system to maintain global concentration robustness of the diffusible response regulator CheY with respect to several dominant perturbations. Our framework provides a counterpoint to the hypothesis that cellular function relies on an extensive machinery to fine-tune or control intracellular parameters. Rather, we suggest that for a large class of perturbations, there exists an appropriate topology that renders the network output invariant to the respective perturbations