2 research outputs found
Organ Specific Head Coil for High Resolution Mouse Brain Perfusion Imaging using Magnetic Particle Imaging
Magnetic Particle Imaging (MPI) is a novel and versatile imaging modality
developing towards human application. When up-scaling to human size, the
sensitivity of the systems naturally drops as the coil sensitivity depends on
the bore diameter. Thus, new methods to push the sensitivity limit further have
to be investigated to cope for this loss. In this paper a dedicated surface
coil improving the sensitvity in cerebral imaging applications was developed.
Similar to MRI the developed surface coil improves the sensitivity due to the
closer vicinity to the region of interest. With the developed surface coil
presented in this work, it is possible to image tracer samples containing only
896 pg iron and detect even small vessels and anatomical structures within a
wild type mouse model. As current sensitivity measures are dependent on the
tracer system a new method for determining a sensitivity measure without this
dependence on the tracer is presented and verified to enable comparison between
MPI receiver systems.Comment: 9 pages 7 figures original articl