How effective and efficient are multiobjective evolutionary algorithms at hydrologic model calibration?

International audienceThis study provides a comprehensive assessment of state-of-the-art evolutionary multiobjective optimization (EMO) tools' relative effectiveness in calibrating hydrologic models. The relative computational efficiency, accuracy, and ease-of-use of the following EMO algorithms are tested: Epsilon Dominance Nondominated Sorted Genetic Algorithm-II (?-NSGAII), the Multiobjective Shuffled Complex Evolution Metropolis algorithm (MOSCEM-UA), and the Strength Pareto Evolutionary Algorithm 2 (SPEA2). This study uses three test cases to compare the algorithms' performances: (1) a standardized test function suite from the computer science literature, (2) a benchmark hydrologic calibration test case for the Leaf River near Collins, Mississippi, and (3) a computationally intensive integrated surface-subsurface model application in the Shale Hills watershed in Pennsylvania. One challenge and contribution of this work is the development of a methodology for comprehensively comparing EMO algorithms that have different search operators and randomization techniques. Overall, SPEA2 attained competitive to superior results for most of the problems tested in this study. The primary strengths of the SPEA2 algorithm lie in its search reliability and its diversity preservation operator. The biggest challenge in maximizing the performance of SPEA2 lies in specifying an effective archive size without a priori knowledge of the Pareto set. In practice, this would require significant trial-and-error analysis, which is problematic for more complex, computationally intensive calibration applications. ?-NSGAII appears to be superior to MOSCEM-UA and competitive with SPEA2 for hydrologic model calibration. ?-NSGAII's primary strength lies in its ease-of-use due to its dynamic population sizing and archiving which lead to rapid convergence to very high quality solutions with minimal user input. MOSCEM-UA is best suited for hydrologic model calibration applications that have small parameter sets and small model evaluation times. In general, it would be expected that MOSCEM-UA's performance would be met or exceeded by either SPEA2 or ?-NSGAII

Spin wave emission by spin-orbit torque antennas

We study the generation of propagating spin waves in Ta/CoFeB waveguides by spin-orbit torque antennas and compare them to conventional inductive antennas. The spin-orbit torque was generated by a transverse microwave current across the magnetic waveguide. The detected spin wave signals for an in-plane magnetization across the waveguide (Damon-Eshbach configuration) exhibited the expected phase rotation and amplitude decay upon propagation when the current spreading was taken into account. Wavevectors up to about 6 rad/$\mu$m could be excited by the spin-orbit torque antennas despite the current spreading, presumably due to the non-uniformity of the microwave current. The relative magnitude of generated anti-damping spin-Hall and Oersted fields was calculated within an analytic model and it was found that they contribute approximately equally to the total effective field generated by the spin-orbit torque antenna. Due to the ellipticity of the precession in the ultrathin waveguide and the different orientation of the anti-damping spin-Hall and Oersted fields, the torque was however still dominated by the Oersted field. The prospects for obtaining a pure spin-orbit torque response are discussed, as are the energy efficiency and the scaling properties of spin-orbit torque antennas.Comment: 20 pages, 5 figure

Magnetic dephasing in mesoscopic spin glasses

We have measured Universal Conductance Fluctuations in the metallic spin glass Ag:Mn as a function of temperature and magnetic field. From this measurement, we can access the phase coherence time of the electrons in the spin glass. We show that this phase coherence time increases with both the inverse of the temperature and the magnetic field. From this we deduce that decoherence mechanisms are still active even deep in the spin glass phase

Operational experience with a CID camera system

In future high intensity, high energy accelerators particle losses must be minimized as activation of the vacuum chambers or other components makes maintenance and upgrade work time consuming and costly. It is imperative to have a clear understanding of the mechanisms that can lead to halo formation, and to have the possibility to test available theoretical models with an adequate experimental setup. Measurements based on optical transition radiation (OTR) provide an interesting opportunity for analyzing the transverse beam profile due to the fast time response and very good linearity of the signal with respect to the beam intensity. On the other hand, the dynamic range of typical acquisition systems as they are used in the CLIC test facility (CTF3) is typically limited and must be improved before these systems can be applied to halo measurements. One possibility for high dynamic range measurements is an innovative camera system based on charge injection device (CID) technology. With possible future measurements in CTF3 in mind, comparative measurements performed with this innovative camera system, a standard CCD camera and a step-by-step measurement technique based on a small photomultiplier are summarized with emphasi

The fiscal consequences of public health investments in disease-modifying therapies for the treatment of multiple sclerosis in Sweden

Background and aims: The economic consequences of multiple sclerosis (MS) are broader than those observed within the health system. The progressive nature suggests that people will not be able to live a normal productive life and will gradually require public benefits to maintain living standards. This study investigates the public economic impact of MS and how investments in disease-modifying therapies (DMTs) influence the lifetime costs to government attributed to changes in lifetime tax revenue and disability benefits based on improved health status linked to delayed disease progression. Methods: Disease progression rates from previous MS Markov cohort models were applied to interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab using a public economic framework. The established relationship between expanded disability status scale and work-force participation, annual earnings, and disability rates for each DMT were applied. Subsequently, we assessed the effect of DMTs on discounted governmental costs consisting of health service costs, social insurance and disability costs, and changes in lifetime tax revenues. Results: Fiscal benefits attributed to informal care and community services savings for interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab were SEK340,387, SEK486,837, SEK257,330, and SEK958,852 compared to placebo, respectively. Tax revenue gains linked to changes in lifetime productivity for interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab were estimated to be SEK27,474, SEK39,659, SEK21,661, and SEK75,809, with combined fiscal benefits of cost savings and tax revenue increases of SEK410,039, SEK596,592, SEK326,939, and SEK1,208,023, respectively. Conclusion: The analysis described here illustrates the broader public economic benefits for government attributed to changes in disease status. The lifetime social insurance transfer costs were highest in non-treated patients, and lower social insurance costs were demonstrated with DMTs. These findings suggest that focusing cost-effectiveness analysis only on health costs will likely underestimate the value of DMTs.</p

The fiscal consequences of public health investments in disease-modifying therapies for the treatment of multiple sclerosis in Sweden

Background and aims: The economic consequences of multiple sclerosis (MS) are broader than those observed within the health system. The progressive nature suggests that people will not be able to live a normal productive life and will gradually require public benefits to maintain living standards. This study investigates the public economic impact of MS and how investments in disease-modifying therapies (DMTs) influence the lifetime costs to government attributed to changes in lifetime tax revenue and disability benefits based on improved health status linked to delayed disease progression. Methods: Disease progression rates from previous MS Markov cohort models were applied to interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab using a public economic framework. The established relationship between expanded disability status scale and work-force participation, annual earnings, and disability rates for each DMT were applied. Subsequently, we assessed the effect of DMTs on discounted governmental costs consisting of health service costs, social insurance and disability costs, and changes in lifetime tax revenues. Results: Fiscal benefits attributed to informal care and community services savings for interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab were SEK340,387, SEK486,837, SEK257,330, and SEK958,852 compared to placebo, respectively. Tax revenue gains linked to changes in lifetime productivity for interferon beta-1a, peginterferon beta-1a, dimethyl fumarate, and natalizumab were estimated to be SEK27,474, SEK39,659, SEK21,661, and SEK75,809, with combined fiscal benefits of cost savings and tax revenue increases of SEK410,039, SEK596,592, SEK326,939, and SEK1,208,023, respectively. Conclusion: The analysis described here illustrates the broader public economic benefits for government attributed to changes in disease status. The lifetime social insurance transfer costs were highest in non-treated patients, and lower social insurance costs were demonstrated with DMTs. These findings suggest that focusing cost-effectiveness analysis only on health costs will likely underestimate the value of DMTs.</p

A transmission problem across a fractal self-similar interface

We consider a transmission problem in which the interior domain has infinitely ramified structures. Transmission between the interior and exterior domains occurs only at the fractal component of the interface between the interior and exterior domains. We also consider the sequence of the transmission problems in which the interior domain is obtained by stopping the self-similar construction after a finite number of steps; the transmission condition is then posed on a prefractal approximation of the fractal interface. We prove the convergence in the sense of Mosco of the energy forms associated with these problems to the energy form of the limit problem. In particular, this implies the convergence of the solutions of the approximated problems to the solution of the problem with fractal interface. The proof relies in particular on an extension property. Emphasis is put on the geometry of the ramified domain. The convergence result is obtained when the fractal interface has no self-contact, and in a particular geometry with self-contacts, for which an extension result is proved

EFFECTS OF ZOLEDRONATE ON TWO- AND THREE-DIMENSIONAL OSTEOBLAST CULTURES

Oral Communication presented at the ";;Forum des Jeunes Chercheurs";;, Brest (France) 2011