Regularities and Irregularities in Order Flow Data

We identify and analyze statistical regularities and irregularities in the recent order flow of different NASDAQ stocks, focusing on the positions where orders are placed in the orderbook. This includes limit orders being placed outside of the spread, inside the spread and (effective) market orders. We find that limit order placement inside the spread is strongly determined by the dynamics of the spread size. Most orders, however, arrive outside of the spread. While for some stocks order placement on or next to the quotes is dominating, deeper price levels are more important for other stocks. As market orders are usually adjusted to the quote volume, the impact of market orders depends on the orderbook structure, which we find to be quite diverse among the analyzed stocks as a result of the way limit order placement takes place.Comment: 10 pages, 9 figure

Quantitative interpretation of bone marrow biopsies in MPN—what's the point in a molecular age?

The diagnosis of myeloproliferative neoplasms (MPN) requires the integration of clinical, morphological, genetic and immunophenotypic findings. Recently, there has been a transformation in our understanding of the cellular and molecular mechanisms underlying disease initiation and progression in MPN. This has been accompanied by the widespread application of high-resolution quantitative molecular techniques. By contrast, microscopic interpretation of bone marrow biopsies by haematologists/haematopathologists remains subjective and qualitative. However, advances in tissue image analysis and artificial intelligence (AI) promise to transform haematopathology. Pioneering studies in bone marrow image analysis offer to refine our understanding of the boundaries between reactive samples and MPN subtypes and better capture the morphological correlates of high-risk disease. They also demonstrate potential to improve the evaluation of current and novel therapeutics for MPN and other blood cancers. With increased therapeutic targeting of diverse molecular, cellular and extra-cellular components of the marrow, these approaches can address the unmet need for improved objective and quantitative measures of disease modification in the context of clinical trials. This review focuses on the state-of-the-art in image analysis/AI of bone marrow tissue, with an emphasis on its potential to complement and inform future clinical studies and research in MPN

Estimation and correction of geometric distortions in side-scan sonar images

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution March 1990This thesis introduces a new procedure for the enhancement of acoustic images of the bottom of the sea produced by side-scan sonars. Specifically, it addresses the problem of estimating and correcting geometric distortions frequently observed in such images as a consequence of motion instabilities of the sonar array. This procedure estimates the geometric distortions from the image itself, without requiring any navigational or attitude measurements. A mathematical model for the distortions is derived from the geometry of the problem, and is applied to estimates of the local degree of geometric distortion obtained by cross-correlating segments of adjacent lines of the image. The model parameters are then recursively estimated through deterministic least-squares estimation. An alternative approach based on adaptive Kalman filtering is also proposed, providing a natural framework in which a priori information about the array dynamics may be easily incorporated. The estimates of the parameters of the distortion model are used to rectify the image, and may also be used for estimating the attitude parameters of the array. A simulation is employed to evaluate the effectiveness of this technique and examples of its application to high-resolution side-scan sonar images are provided.This work was produced under sponsorship of the Conselho Nacional de Desenvolvimento Cient{jico e Tecnol6gico (CNPq), an agency of the Government of the Federative Republic of Brazil, and was supported in part by the Defense Advanced Research Projects Agency monitored by the Office of Naval Research under Grant No. N00014-89-J-1489, in part by the National Science Foundation under Grant No. MIP 87-14969, and in part by Sanders Associates, Incorporated

Hydrogen-poor superluminous stellar explosions

Supernovae (SNe) are stellar explosions driven by gravitational or thermonuclear energy, observed as electromagnetic radiation emitted over weeks or more. In all known SNe, this radiation comes from internal energy deposited in the outflowing ejecta by either radioactive decay of freshly-synthesized elements (typically 56Ni), stored heat deposited by the explosion shock in the envelope of a supergiant star, or interaction between the SN debris and slowly-moving, hydrogen-rich circumstellar material. Here we report on a new class of luminous SNe whose observed properties cannot be explained by any of these known processes. These include four new SNe we have discovered, and two previously unexplained events (SN 2005ap; SCP 06F6) that we can now identify as members. These SNe are all ~10 times brighter than SNe Ia, do not show any trace of hydrogen, emit significant ultra-violet (UV) flux for extended periods of time, and have late-time decay rates which are inconsistent with radioactivity. Our data require that the observed radiation is emitted by hydrogen-free material distributed over a large radius (~10^15 cm) and expanding at high velocities (>10^4 km s^-1). These long-lived, UV-luminous events can be observed out to redshifts z>4 and offer an excellent opportunity to study star formation in, and the interstellar medium of, primitive distant galaxies.Comment: Accepted to Nature. Press embargoed until 2011 June 8, 18:00 U

Early-time Spectropolarimetry of the Asymmetric Type II Supernova SN 2023ixf

We present six epochs of optical spectropolarimetry of the Type II supernova (SN) 2023ixf ranging from $\sim$ 2 to 15 days after the explosion. Polarimetry was obtained with the Kast double spectrograph on the Shane 3 m telescope at Lick Observatory, representing the earliest such observations ever captured for an SN. We observe a high continuum polarization $p_{\text{cont}} \approx 1$ % on days +1.4 and +2.5 before dropping to 0.5 % on day +3.5, persisting at that level up to day +14.5. Remarkably, this change coincides temporally with the disappearance of highly ionized "flash" features. The decrease of the continuum polarization is accompanied by a $\sim 70^\circ$ rotation of the polarization position angle ($PA$) as seen across the continuum. The early evolution of the polarization may indicate different geometric configurations of the electron-scattering atmosphere as seen before and after the disappearance of the emission lines associated with highly-ionized species (e.g., He II, C IV, N III), which are likely produced by elevated mass loss shortly prior to the SN explosion. We interpret the rapid change of polarization and $PA$ from days +2.5 to +4.5 as the time when the SN ejecta emerge from the dense asymmetric circumstellar material (CSM). The temporal evolution of the continuum polarization and the $PA$ is consistent with an aspherical SN explosion that exhibits a distinct geometry compared to the CSM. The rapid follow-up spectropolarimetry of SN 2023ixf during the shock ionization phase reveals an exceptionally asymmetric mass-loss process leading up to the explosion.Comment: Submitted to Ap

A 200-year perspective on alternative stable state theory and lake management from a biomanipulated shallow lake

Abstract. Multiple stressors to a shallow lake ecosystem have the ability to control the relative stability of alternative states (clear, macrophyte-dominated or turbid, algaldominated). As a consequence, the use of remedial biomanipulations to induce trophic cascades and shift a turbid lake to a clear state is often only a temporary solution. Here we show the instability of short-term manipulations in the shallow Lake Christina (Minnesota, USA) is governed by the long-term state following a regime shift in the lake. During the modern, managed period of the lake, three top-down manipulations (fish kills) were undertaken inducing temporary (5-10 years) unstable clear-water states. Paleoecological remains of diatoms, along with proxies of primary production (total chlorophyll a and total organic carbon accumulation rate) and trophic state (total P) from sediment records clearly show a single regime shift in the lake during the early 1950s; following this shift, the functioning of the lake ecosystem is dominated by a persistent turbid state. We find that multiple stressors contributed to the regime shift. First, the lake began to eutrophy (from agricultural land use and/or increased waterfowl populations), leading to a dramatic increase in primary production. Soon after, the construction of a dam in 1936 effectively doubled the depth of the lake, compounded by increases in regional humidity; this resulted in an increase in planktivorous and benthivorous fish reducing phytoplankton grazers. These factors further conspired to increase the stability of a turbid regime during the modern managed period, such that switches to a clear-water state were inherently unstable and the lake consistently returned to a turbid state. We conclude that while top-down manipulations have had measurable impacts on the lake state, they have not been effective in providing a return to an ecosystem similar to the stable historical period. Our work offers an example of a well-studied ecosystem forced by multiple stressors into a new long-term managed period, where manipulated clearwater states are temporary, managed features

A molecular genetic perspective of reproductive development in grapevine

The grapevine reproductive cycle has a number of unique features. Inflorescences develop from lateral meristems (anlagen) in latent buds during spring and summer and enter a dormant state at a very immature stage before completing development and producing flowers and berries the following spring. Lateral meristems are unique structures derived from the shoot apical meristem and can either develop into an inflorescence or a tendril. How the grapevine plant controls these processes at the molecular level is not understood, but some progress has been made by isolating and studying the expression of flowering genes in wild-type and mutant grapevine plants. Interestingly, a number of flowering genes are also expressed during berry development. This paper reviews the current understanding of the genetic control of grapevine flowering and the impact of viticulture management treatments and environmental variables on yield. While the availability of the draft genome sequence of grapevine will greatly assist future molecular genetic studies, a number of issues are identified that need to be addressed—particularly rapid methods for confirming gene function and linking genes to biological processes and traits. Understanding the key interactions between environmental factors and genetic mechanisms controlling the induction and development of inflorescences, flowers, and berries is also an important area that requires increased emphasis, especially given the large seasonal fluctuations in yield experienced by the crop and the increasing concern about the effect of climate change on existing wine-producing regions

89 New Ultracool Dwarf Co-Moving Companions Identified With The Backyard Worlds: Planet 9 Citizen Science Project

We report the identification of 89 new systems containing ultracool dwarf companions to main sequence stars and white dwarfs, using the citizen science project Backyard Worlds: Planet 9 and cross-reference between Gaia and CatWISE2020. Thirty-two of these companions and thirty-three host stars were followed up with spectroscopic observations, with companion spectral types ranging from M7-T9 and host spectral types ranging from G2-M9. These systems exhibit diverse characteristics, from young to old ages, blue to very red spectral morphologies, potential membership to known young moving groups, and evidence of spectral binarity in 9 companions. Twenty of the host stars in our sample show evidence for higher order multiplicity, with an additional 11 host stars being resolved binaries themselves. We compare this sample's characteristics with those of the known stellar binary and exoplanet populations, and find our sample begins to fill in the gap between directly imaged exoplanets and stellary binaries on mass ratio-binding energy plots. With this study, we increase the population of ultracool dwarf companions to FGK stars by $\sim$42\%, and more than triple the known population of ultracool dwarf companions with separations larger than 1,000 au, providing excellent targets for future atmospheric retrievals.Comment: 61 pages, 11 figures, 11 tables. Accepted for publication in A