The observation of Extensive Air Showers from an Earth-Orbiting Satellite

In this paper we review the main issues that are relevant for the detection of Extensive Air Showers (EAS) from space. EAS are produced by the interaction of Ultra-High Energy Cosmic Particles (UHECP) with the atmosphere and can be observed from an orbiting telescope by detecting air fluorescence UV light. We define the requirements and provide the main formulas and plots needed to design and optimize a suitable telescope. We finally estimate its expected performances in ideal conditions.Comment: 24 pages, 10 figures; submitted to Astroparticle Physics 27 pages, 14 figures; major revision; added new figures and sections; typos fixed. arXiv admin note: substantial text overlap with arXiv:0810.571

Autonomous dexterous end-effectors for space robotics

The development of a knowledge-based controller is summarized for the Belgrade/USC robot hand, a five-fingered end effector, designed for maximum autonomy. The biological principles of the hand and its architecture are presented. The conceptual and software aspects of the grasp selection system are discussed, including both the effects of the geometry of the target object and the task to be performed. Some current research issues are presented

Travesty of Trust: A Critical Look at Racial and Ethnic Discrimination in the Healthcare Setting

The purpose of this thesis is to review the overarching purpose of healthcare, examine race-related disparities in minority patient outcomes within specific fields of medical practice, and discuss whether these disparities are the result of racial discrimination within the clinical setting, or are due at least partially to genetic and environmental factors, followed by an examination of how cross-cultural education for healthcare professionals can be improved to equip medical personnel with the attitudes, knowledge, and skills necessary to provide effective care to a culturally diverse patient populace. The benefits of recruiting a culturally and linguistically diverse team of healthcare providers are also discussed. Review of literature seems to indicate that poor patient outcomes for minority groups are due at least in part to forms of discrimination in healthcare provision, and therefore academic initiatives to implement for current and future medical practitioners in order to address current racial disparities and discrimination in healthcare and improve health outcomes for minority patients are also examined

Alterations in the vimentin cytoskeleton in response to single impact load in an in vitro model of cartilage damage in the rat.

BACKGROUND: Animal models have provided much information on molecular and cellular changes in joint disease, particularly OA. However there are limitations to in vivo work and single tissue in vitro studies can provide more specific information on individual events. The rat is a commonly used laboratory species but at the current time only in vivo models of rat OA are available to study. The purpose of this study was to investigate the damage that single impact load (SIL) of 0.16J causes in a rat cartilage in vitro model and assess whether this load alters the arrangement of vimentin. METHODS: Rat cartilage was single impact loaded (200 g from 8 cm) and cultured for up to 48 hours (n = 72 joints). Histological changes were measured using a semi-quantitative modified Mankin score. Immunolocalisation was used to identify changes in vimentin distribution. RESULTS: SIL caused damage in 32/36 cartilage samples. Damage included surface fibrillation, fissures, fragmentation, changes in cellularity and loss of proteoglycan. SIL caused a statistically significant increase in modified Mankin score and chondrocyte clusters over time. SIL caused vimentin disassembly (as evidenced by collapse of vimentin around the nucleus). CONCLUSION: This study describes a model of SIL damage to rat cartilage. SIL causes changes in histological/chemical parameters which have been measured using a semi-quantitative modified Mankin score. Single impact load also causes changes in the pattern of vimentin immunoreactivity, indicating vimentin dissassembley. Using a semi-quantitative scoring system the disassembly was shown to be statistically significant in SIL damaged cartilage. The changes described in this paper suggest that this novel single tissue rat model of joint damage is a possible candidate model to replace in vivo models.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Design thinking in entrepreneurship education : understanding framing and placements of problems

Abstract: Orientation: Design thinking presented an alternative lens for entrepreneurship education. Research purpose: The purpose of this article was to illustrate (with a framework) the benefits of encouraging a design-based mindset when exploring problem placement and framing to create new opportunities for entrepreneurship students. Motivation for the study: The role of placement and framing of open-complex problems has not been fully embraced in the literature on design thinking for entrepreneurship education. The seminal work of Richard Buchannan (a great influencer in the realm of design thinking) offered a deeper insight into the placement and framing of problems that could assist educators to facilitate thinking skills relevant to deal with the unpredictable contexts that future entrepreneurs have to be prepared for..

The National Coastal Zone Management Act of 1972

This Article will focus on those innovative sections of the Coastal Zone Management Act which provide for this expanded exercise of state-based review and regulation

Sexual distress and quality of life among women with bipolar disorder

Abstract Background Information on the association between bipolar disorder (BD), sexual satisfaction, sexual function, sexual distress and quality of life (QoL) is sparse. This study aims, in women with BD, to (i) investigate sexual dysfunction, sexual distress, general sexual satisfaction and QoL; (ii) explore whether sexual distress was related to affective symptoms and (iii) investigate whether QoL was associated with sexual distress. The study is a questionnaire survey in an outpatient cohort of women with BD using: Changes in Sexual Functioning Questionnaire, Female Sexual Distress Scale, Altman Self-Rating Mania Scale (ASRM), Major Depression Inventory (MDI) and The World Health Organisation Quality of Life-Brief. Results In total, 61 women (age range 19–63, mean 33.7 years) were recruited. Overall, 54% reported sexual distress (n = 33) and 39% were not satisfied with their sexual life (n = 24). Women with BD were significantly more sexually distressed in comparison with Danish women from the background population but they did not have a higher prevalence of impaired sexual function. Better sexual function was positively associated with ASRM scores while MDI scores were associated with more distress. Finally, the group of non-sexually distressed women with BD reported higher QoL scores compared with the sexually distressed group. Conclusions Women with BD exhibited a high prevalence of sexual distress and their sexual function seemed associated with their actual mood symptoms and perception of QoL