2,8-Dimethyl-10-p-tolyl-10H-phenoxaphosphine

The title compound (systematic name: 3,6-dimethyl-10-p-tolyl-9-oxa-10-phosphaanthracene), C21H19OP, is a precursor for the preparation of a bidentate xanthene-based ligand, in which the dihedral angle between the toluene ring and the phenoxaphosphine ring system is 83.26 (3)°. The geometry at the P atom is pyramidal, resulting in a longer C—P bond length as compared to the two ring C—P bonds

4,6-Bis(diphenyl­phosphan­yl)-2,8-di­methyl­phenoxathiin dichloro­methane monosolvate

The title compound, C38H30OP2S·CH2Cl2, belongs to the xanthene family of ligands containing S- and O-donor atoms in the central heterocylic ring. Positions 2 and 8 on the xanthene backbone are functionalized with methyl groups to allow for the selective functionalization of the backbone at positions 4 and 6 with diphenyl­phosphanyl units. The title compound shows a significant ‘roof-like’ bending along the axis of planarity involving the O- and S-donor atoms and the benzene rings, resulting in a dihedral angle between the mean planes of the benzene rings of 32.88 (13)°

4,6-Bis(diphenyl­phosphan­yl)dibenzo[b,d]furan

The asymmetric unit of the title compound, C36H26OP2, comprises two mol­ecules which have slightly different conformations of the phenyl ring substituents. In both mol­ecules, the dibenzofuran unit is close to being planar, with dihedral angles of 3.20 (3) and 1.86 (2)° for the two mol­ecules. Its planarity affects the intra­molecular distances between P atoms, with P⋯P distances of 5.574 (2) and 5.485 (2) Å for the two mol­ecules

A P,O,P′-tridentate mixed-donor scorpionate ligand: 6-[4,6-bis­(diphenyl­phosphino)-10H-phenoxazin-10-yl]hexan-1-ol

The title compound, C42H39NO2P2, is a P,O,P′-tridentate scorpionate-type ligand and has one mol­ecule in the asymmetric unit. The angles involving the P atoms range from 100.21 (7) to 104.89 (7)°. The N-hexa­nol group was found to be disordered and was refined over two positions with final occupancies of 0.683 (3) and 0.317 (3) which affected the C—O and C—N bond lengths. The bond lengths for C—O range from 1.402 (2) to 1.415 (2) Å and for C—N from 1.410 (2) to 1.448 (3) Å for the major disorder component; the corresponding ranges for the minor disorder component are 1.429 (3)–1.408 (3) and 1.474 (3)–1.474 (4) Å

Substitutional disorder in the substituted nixantphos ligand C39H32Br0.27Cl0.73NOP2

The structure of 10-(3-bromo/chloro­prop­yl)-4,6-bis­(diphenyl­phosphino)-10H-phenoxazine, C39H32Br0.27Cl0.73NOP2, shows chloro/bromo substitutional disorder in a 3:1 ratio. For application as a ligand in catalysis, the intra­molecular P⋯P distance of 4.263 (2) Å is relevant. The phenoxazine ring system is essentially planar

Dexamethasone-Loaded, PEGylated, vertically aligned, multiwalled carbon nanotubes for potential ischemic stroke intervention

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4,6-Bis(diphenylphosphino)phenoxazine (nixantphos)

The title compound, C36H27NOP2, has been reported as a ligand on rhodium for the catalysis of hydroformylation reactions. The key feature of the compound is the intramolecular P...P distance of 4.255 (2) Å. The bond angles at the P atoms range from 99.93 (10) to 103.02 (10)°. The phenoxazine ring system is essentially planar and a non-crystallographic mirror plane through the N...O vector bisects the molecule. The C—O bond lengths range from 1.388 (2) to 1.392 (2) Å and the C—N bond lengths range from 1.398 (3) to 1.403 (3) Å

Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair

Regenerative medicine is an active research sphere that focuses on the repair, regeneration, and replacement of damaged tissues and organs. A plethora of innovative wound dressings and skin substitutes have been developed to treat cutaneous wounds and are aimed at reducing the length or need for a hospital stay. The inception of biomaterials with the ability to interact with cells and direct them toward desired lineages has brought about innovative designs in wound healing and tissue engineering. This cellular engagement is achieved by cell cues that can be biochemical or biophysical in nature. In effect, these cues seep into innate repair pathways, cause downstream cell behaviours and, ultimately, lead to advantageous healing. This review will focus on biomolecules with encoded biomimetic, instructive prompts that elicit desired cellular domino effects to achieve advanced wound repair. The wound healing dressings covered in this review are based on functionalized biopolymeric materials. While both biophysical and biochemical cues are vital for advanced wound healing applications, focus will be placed on biochemical cues and in vivo or clinical trial applications. The biochemical cues aforementioned will include peptide therapy, collagen matrices, cell-based therapy, decellularized matrices, platelet-rich plasma, and biometals