Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

AbstractPurposeTo evaluate the efficacy and safety of the glycoside fraction of fenugreek (Trigonella foenum-graecum) seeds (Fenu-FG) on physiological parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design.MethodsSixty healthy male subjects were randomized to ingest capsules of Fenu-FG (1 capsule of 300 mg, twice per day) or the matching placebo at a 1:1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment (baseline) and at the end of the treatment (8 weeks). The efficacy outcome included serum testosterone (total and free) levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity (serum creatinine and blood urea nitrogen), and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed.ResultsFenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplementation was found to be safe and well-tolerated.ConclusionFenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects

EFFICACY AND SAFETY OF STANDARDIZED CINNAMON BARK EXTRACT FOR THE PREVENTION OF CHEMOTHERAPY-INDUCED WEIGHT LOSS AND ALOPECIA IN PATIENTS WITH BREAST CANCER: A RANDOMIZED, DOUBLE-BLIND, AND PLACEBO-CONTROLLED STUDY

Objective: The objective of the study was to evaluate the effects of IND02 (standardized Cinnamon bark extract) supplementation for the prevention of side effects of cancer chemotherapy in female patients with breast cancer. Methods: The study was conducted using double-blind, placebo-controlled design in 34 female breast cancer patients during the first 4 consecutive 21-day cycles of the standard chemotherapy regimen. The active treatment (IND02 capsules, 400 mg, one capsule, and thrice a day) or matching placebo was orally administrated in randomized (1:1 ratio) patients. The efficacy outcome measures were reduction in chemotherapy-induced weight loss, alopecia (hair fall), and other side effects. The safety outcome measures were hematology, ECG, vital signs, adverse event monitoring, and laboratory safety measurements. Results: The patients on the treatment with IND02 had shown significant protection from chemotherapy-induced severe weight loss (cachexia) and alopecia (reduced hair density and % hairs in the anagen phase, and increased % hairs in telogen phase) which was seen in the placebo group. IND02 treatment was found safe and well-tolerated during the study. Conclusion: Concomitant use of IND02 in breast cancer patients during breast cancer chemotherapy showed a clinical promise regarding efficacy and safety in preventing chemotherapy-induced weight loss and alopecia

Case report: Sleep deprivation presenting as acute psychosis

Sleeping is a basic human need and plays a key role in good health and well-being. Sleep deficiency can lead to physical and mental health problems, injuries, loss of productivity, and even a greater risk of death. Sleep deprivation is seen in several psychiatric disorders, and there may be a cause or effect relationship. Sleep-deprived individuals may have trouble making decisions, solving problems, controlling their emotions and behavior, and coping with stress or change. We report a case who started having sleep deprivation over 15 days following a stressor, which resulted in an acute psychosis-like condition with associated disorientation and perplexity. However, the patient responded to benzodiazepine medication given for the restoration of her sleep cycle and did not require any antipsychotics. There was also complete amelioration of her behavioral and thought disturbances

1H-Benzimidazol-3-ium-2-carboxyl­ate dihydrate

The title compound, C8H6N2O2·2H2O, crystallized as a zwitterion with the carboxyl group deprotonated and the imidazole group protonated. The dihedral angle between the benzimidazole ring and the pendant –CO2 group is 0.62 (2)°. In the crystal, mol­ecules are linked into a three-dimensional network by N—H⋯O and O—H⋯O hydrogen bonds

Effect of cyclodextrin garcinol complex on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats

Background: Garcinol is a polyisoprenylated benzophenone derivative present in the fruit rinds of Garcinia species namely Garcinia indica (common name 'Kokum') and Garcinia cambogia (common name 'Gombogee'). It appears to be involved in the regulation of oxidative stress and antioxidant capacity of heart tissue when the heart is subjected to oxidative stress in various pathogenic conditions/ chemical agent. But garcinol is associated with severe limitation of instability and poor bioavailability which can be improved complexing cyclodextrin with garcinol (garcinol complex). Objective: The objective of the present study was to investigate effect of cyclodextrin with garcinol complex (20 mg/kg), on Iso induced cardiotoxicity and cardiac hypertrophy in rats.Methods: Male Wistar rats (250-300g) were divided into following 4 groups of six animals each. Group 1 was control (distilled water 2 ml/kg/day orally for 18 days and water for injection by i.p. from day 9 to day 18), group 2 was cyclodextrin (cyclodextrin 2 ml/kg/day orally for 18 days and water for injection by i.p. from day 9 to day 18), group 3 Iso (distilled water 2 ml/kg/day orally for 18 days and isoproterenol 1 mg/kg by i.p. from day 9 to day 18), group 4 garcinol complex (20 mg/kg/day orally for 18 days and isoproterenol 1 mg/kg by i.p. from day 9 to day 18). After 24 hrs of last dose of isoproterenol, electrocardiogram (ECG) and heart rate were recorded in anaesthetized rats. The animals were sacrificed by overdose of ether. The hearts of animals were isolated for measurement of reduced glutathione (GSH) and lipid peroxidation (MDA). Results: Isoproterenol treated rats showed significant myocardial hypertrophy, decreased endogenous antioxidants when compared with the control group animals. The garcinol complex (20 mg/kg) treatment for 18 days showed significant cardioprotective activity by lowering the myocardial hypertrophy, level of lipid peroxidation (MDA content) as well as elevated the level of GSH. The results suggest pre-treatment of garcinol complex (20 mg/kg), may offer potential benefits in the management of cardiotoxicity and cardiac hypertrophy. Conclusion: It is thus concluded that Garcinol Complex (20 mg/kg) administration offered significant protection against isoproterenol induced cardiotoxicity and cardiac hypertrophy as well as decreased myocardial injury by preservation of endogenous antioxidants and reduction of lipid peroxidation in rat heart

Realtime video survillence and analytics

Providing smart and intelligent security solutions for home as well as large business is a challenging task, in recent this is a currently a booming topic in the IT industry or in almost every area, where today’s challenges are different the end user needs to have a intelligent solution as well as a cheap price to pay. We therefore represent a software system which uses traditional hardware but has new modern features like object recognition, Intrusion detection, video analytics, Real-time video feed over smart phone. It aims at alerting the user as quick as possible so that the user can stop any unwanted activity going on in the video frame or alert the police.it is believed that using a traditional video surveillance systems a lot of unwanted video data is stored and this causes a lot of memory wastage, and even there is no possible way of use of artificial intelligence and video analytics capability. This decreases the citizen security as well as the capability of the system is not fully used. We have a feature of real-time broad casting the live suspicious video feed to the authenticated user by use of mobile devices such as PDA, Smart phone, Tablets so the user can access the video feed anywhere, any time on any device. The user can also turn on and off the notification and some features or even increase the resolution, zoom in and zoom out. The system uses mechanisms such as deep learning, artificial intelligence, and video analytics to perform the above tasks

Preclinical safety evaluation of low molecular weight galactomannans based standardized fenugreek seeds extract

The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprague-Dawley (SD) rats at a dose of 2000 mg/kg with vehicle control (VC) group (n = 5 per sex per group) as per OECD guideline no. 423. For the repeated dose toxicity study, the SD rats were orally administered with a daily oral dose of LMWGAL-TF 250, 500 and 1000 mg/kg/day with VC group (n = 15 per sex) for a period of 90 days followed by a recovery period of 28 days as per OECD guideline no. 408. The effects on body weight, food and water consumption, organ weights with hematology, clinical biochemistry, and histology were studied. The mutagenic potential of LMWGAL-TF was tested using reverse mutation assay (AMES test, OECD guideline No. 471). The LMWGAL-TF did not show mortality or treatment-related adverse signs during acute (dose 2000 mg/kg) and subchronic (90-days repeated dose 250, 500 and 1000 mg/kg) administration. The LMWGAL-TF showed oral lethal dose (LD50) more than 2000 mg/kg during AOT study. The dose of 1000 mg/kg was found as no observed adverse effect level (NOAEL) in rats during subchronic toxicity study. Furthermore, LMWGAL-TF did not show mutagenic potential in vitro. In conclusion, LMWGAL-TF was found safe during acute and subchronic (90 days repeated dose) toxicity studies in rats with no mutagenicity

Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice

Mushrooms are low calorie food with very little fat and are highly suitable for obese persons. With no starch and very low sugars, they are the ‘delight of the diabetics’. Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs. The aim of the present study was to evaluate the effects of aqueous extract of Pleurotus pulmonarius (Lentinaceae) (called as PP-aqu) and its interaction with glyburide in alloxan induced diabetic mice. The diabetic mice treated were with PP-aqu (500 mg/kg, p.o.) alone or combination with glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were collected by orbital sinus puncture using heparinized capillary glass tubes and were analyzed for serum glucose on 0, 7th, 14th, 21st and 28th days. Body weights and mortality were noted during the study period. In oral glucose tolerance test (OGTT), glucose (2.5 g/kg, p.o.) was administered with either vehicle, PP-aqu alone or in combination with glyburide and serum glucose level analyzed at 0, 30, 60 and 120 min after drug administration. Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice. In OGTT, glyburide or PP-aqu treatment alone or their combination produced significant (P < 0.001) increase in glucose threshold. Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide