Coexistence of ferromagnetism and superconductivity in the hybrid ruthenate-cuprate compound RuSr_2GdCu_2O_8 studied by muon spin rotation (\mu SR) and DC-magnetization

We have investigated the magnetic and the superconducting properties of the hybrid ruthenate-cuprate compound RuSr_{2}GdCu_{2}O_{8} by means of zero-field muon spin rotation- (ZF-$\mu$SR) and DC magnetization measurements. The DC-magnetisation data establish that this material exhibits ferromagnetic order of the Ru-moments ($\mu (Ru) \approx 1 \mu_{B}$) below T_{Curie} = 133 K and becomes superconducting at a much lower temperature T_c = 16 K. The ZF-$\mu$SR experiments indicate that the ferromagnetic phase is homogeneous on a microscopic scale and accounts for most of the sample volume. They also suggest that the magnetic order is not significantly modified at the onset of superconductivity.Comment: improved version submitted to Phys. Rev.

Anomalous peak in the superconducting condensate density of cuprate high T_{c} superconductors at a unique critical doping state

The doping dependence of the superconducting condensate density, n_{s}^{o}, has been studied by muon-spin-rotation for Y_{0.8}Ca_{0.2}Ba_{2}(Cu_{1-z}Zn_{z})_{3}O_{7-\delta} and Tl_{0.5-y}Pb_{0.5+y}Sr_{2}Ca_{1-x}Y_{x}Cu_{2}O_{7}. We find that n_{s}^{o} exhibits a pronounced peak at a unique doping state in the slightly overdoped regime. Its position coincides with the critical doping state where the normal state pseudogap first appears depleting the electronic density of states. A surprising correlation between n_{s}^{o} and the condensation energy U_{o} is observed which suggests unconventional behavior even in the overdoped region.Comment: 10 pages, 3 figure

Long-term cyclic persistence in an experimental predator–prey system

Predator–prey cycles rank among the most fundamental concepts in ecology, are predicted by the simplest ecological models and enable, theoretically, the indefinite persistence of predator and prey1,2,3,4. However, it remains an open question for how long cyclic dynamics can be self-sustained in real communities. Field observations have been restricted to a few cycle periods5,6,7,8 and experimental studies indicate that oscillations may be short-lived without external stabilizing factors9,10,11,12,13,14,15,16,17,18,19. Here we performed microcosm experiments with a planktonic predator–prey system and repeatedly observed oscillatory time series of unprecedented length that persisted for up to around 50 cycles or approximately 300 predator generations. The dominant type of dynamics was characterized by regular, coherent oscillations with a nearly constant predator–prey phase difference. Despite constant experimental conditions, we also observed shorter episodes of irregular, non-coherent oscillations without any significant phase relationship. However, the predator–prey system showed a strong tendency to return to the dominant dynamical regime with a defined phase relationship. A mathematical model suggests that stochasticity is probably responsible for the reversible shift from coherent to non-coherent oscillations, a notion that was supported by experiments with external forcing by pulsed nutrient supply. Our findings empirically demonstrate the potential for infinite persistence of predator and prey populations in a cyclic dynamic regime that shows resilience in the presence of stochastic events

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.

Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) that confer these cell-type-specific LPS-induced effects remain poorly understood. Here we report that the integrin α(M) (CD11b) positively regulates LPS-induced signalling pathways selectively in myeloid dendritic cells but not in macrophages. In dendritic cells, which express lower levels of CD14 and TLR4 than macrophages, CD11b promotes MyD88-dependent and MyD88-independent signalling pathways. In particular, in dendritic cells CD11b facilitates LPS-induced TLR4 endocytosis and is required for the subsequent signalling in the endosomes. Consistent with this, CD11b deficiency dampens dendritic cell-mediated TLR4-triggered responses in vivo leading to impaired T-cell activation. Thus, by modulating the trafficking and signalling functions of TLR4 in a cell-type-specific manner CD11b fine tunes the balance between adaptive and innate immune responses initiated by LPS

Curcuminoid Binding to Embryonal Carcinoma Cells: Reductive Metabolism, Induction of Apoptosis, Senescence, and Inhibition of Cell Proliferation

Curcumin preparations typically contain a mixture of polyphenols, collectively referred to as curcuminoids. In addition to the primary component curcumin, they also contain smaller amounts of the co-extracted derivatives demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids can be differentially solubilized in serum, which allows for the systematic analysis of concentration-dependent cellular binding, biological effects, and metabolism. Technical grade curcumin was solubilized in fetal calf serum by two alternative methods yielding saturated preparations containing either predominantly curcumin (60%) or bisdemethoxycurcumin (55%). Continual exposure of NT2/D1 cells for 4–6 days to either preparation in cell culture media reduced cell division (1–5 µM), induced senescence (6–7 µM) or comprehensive cell death (8–10 µM) in a concentration-dependent manner. Some of these effects could also be elicited in cells transiently exposed to higher concentrations of curcuminoids (47 µM) for 0.5–4 h. Curcuminoids induced apoptosis by generalized activation of caspases but without nucleosomal fragmentation. The equilibrium binding of serum-solubilized curcuminoids to NT2/D1 cells incubated with increasing amounts of curcuminoid-saturated serum occurred with apparent overall dissociation constants in the 6–10 µM range. However, the presence of excess free serum decreased cellular binding in a hyperbolic manner. Cellular binding was overwhelmingly associated with membrane fractions and bound curcuminoids were metabolized in NT2/D1 cells via a previously unidentified reduction pathway. Both the binding affinities for curcuminoids and their reductive metabolic pathways varied in other cell lines. These results suggest that curcuminoids interact with cellular binding sites, thereby activating signal transduction pathways that initiate a variety of biological responses. The dose-dependent effects of these responses further imply that distinct cellular pathways are sequentially activated and that this activation is dependent on the affinity of curcuminoids for the respective binding sites. Defined serum-solubilized curcuminoids used in cell culture media are thus suitable for further investigating the differential activation of signal transduction pathways

Some Effects of Surface Curvature on Laminar Boundary-Layer Flow

PhDAerospace materialsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/183364/2/0003787.pd