Surface tension in the dilute Ising model. The Wulff construction

We study the surface tension and the phenomenon of phase coexistence for the Ising model on \mathbbm{Z}^d ($d \geqslant 2$) with ferromagnetic but random couplings. We prove the convergence in probability (with respect to random couplings) of surface tension and analyze its large deviations : upper deviations occur at volume order while lower deviations occur at surface order. We study the asymptotics of surface tension at low temperatures and relate the quenched value $\tau^q$ of surface tension to maximal flows (first passage times if $d = 2$). For a broad class of distributions of the couplings we show that the inequality $\tau^a \leqslant \tau^q$ -- where $\tau^a$ is the surface tension under the averaged Gibbs measure -- is strict at low temperatures. We also describe the phenomenon of phase coexistence in the dilute Ising model and discuss some of the consequences of the media randomness. All of our results hold as well for the dilute Potts and random cluster models

Hepatic stellate cells:central modulators of hepatic carcinogenesis

Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire for the treatment of HCC is severely limited, and therefore effective new therapies are urgently required. Recently, there has been increasing interest focusing on the cellular and molecular interactions between cancer cells and their microenvironment. HCC represents a unique opportunity to study the relationship between a diseased stroma and promotion of carcinogenesis, as 90 % of HCCs arise in a cirrhotic liver. Hepatic stellate cells (HSC) are the major source of extracellular proteins during fibrogenesis, and may directly, or via secreted products, contribute to tumour initiation and progression. In this review we explore the complex cellular and molecular interplay between HSC biology and hepatocarcinogenesis. We focus on the molecular mechanisms by which HSC modulate HCC growth, immune cell evasion and angiogenesis. This is followed by a discussion of recent progress in the field in understanding the mechanistic crosstalk between HSC and HCC, and the pathways that are potentially amenable to therapeutic intervention. Furthermore, we summarise the exciting recent developments in strategies to target HSC specifically, and novel techniques to deliver pharmaceutical agents directly to HSC, potentially allowing tailored, cell-specific therapy for HCC

The behavioral and neoliberal foundations of randomizations

International audienceOne-sentence summary : Randomized controlled trials by behavioural economists pretend to be pragmatic and only interested in what really works to solve practical problems but in reality they have notorious normative and ideological aspects. Key points: Behavioural RCTs ignore contexts and composition effects and reflect the biases of those who perform assessments. Behavioural randomizers presume without demonstrating that market exchanges are the most effective form of regulation for societies in all situations of social life. The positive or negative incentives ("nudges") offered by behavioural economics aim to normalize the behaviour of consumers, users, employees or small/independent producers. They are part of a set of power devices by which individual behaviours are shaped and forced, without their knowledge, to conform to dominant class interests

Wage Determination, Socio-Economic Regulation and the State

This article examines changes in socio-economic regulation and the role of the state in the Netherlands, Spain, the UK, Sweden and Germany, against the background of the theoretical debate on transition from Fordist to post-Fordist growth strategies. The first focus is on reforms in the labour market and the welfare state, and their effect on the political and social processes through which wage norms are generalized in a national economy. The second is on the changing role of the state as an institutional form. The article starts from some basic assumptions of the regulation approach and delineates the status of the concepts of wage relation and wage determination, on the one hand, and the state, on the other. It then considers the debate over modifications to these concepts in the transition from Fordist to post-Fordist growth strategies, drawing on the trajectories of the five countries