Surface tension in the dilute Ising model. The Wulff construction

We study the surface tension and the phenomenon of phase coexistence for the Ising model on \mathbbm{Z}^d ($d \geqslant 2$) with ferromagnetic but random couplings. We prove the convergence in probability (with respect to random couplings) of surface tension and analyze its large deviations : upper deviations occur at volume order while lower deviations occur at surface order. We study the asymptotics of surface tension at low temperatures and relate the quenched value $\tau^q$ of surface tension to maximal flows (first passage times if $d = 2$). For a broad class of distributions of the couplings we show that the inequality $\tau^a \leqslant \tau^q$ -- where $\tau^a$ is the surface tension under the averaged Gibbs measure -- is strict at low temperatures. We also describe the phenomenon of phase coexistence in the dilute Ising model and discuss some of the consequences of the media randomness. All of our results hold as well for the dilute Potts and random cluster models

37^th plenary meeting report of the scientific, technical and economic committee for fisheries (PLEN-11-02)

The Scientific, Technical and Economic Committee for Fisheries hold its 37th plenary on 11-15 July 2011 in Copenhagen (Denmark). The terms of reference included both issues assessments of STECF Expert Working Group reports and additional requests submitted to the STECF by the Commission. Topics dealt with ranged from fisheries economics to management plan evaluation issues

Scientific, Technical and Economic Committee for Fisheries. Evaluation of fishing effort regimes - Deep sea and Western waters (STECF-11-12)

EWG-11-11 meeting was held on 26 – 30 September 2011 in Cadiz (Spain). This Section of the report covers the Deep Sea and Western Waters and provides fleet specific trends in catch (including discards), nominal effort and catch (landings) per unit of effort in order to advise on fleet specific impacts on stocks under multiannual management plans. STECF reviewed the report during its November 2011 plenary meeting

Hepatic stellate cells:central modulators of hepatic carcinogenesis

Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire for the treatment of HCC is severely limited, and therefore effective new therapies are urgently required. Recently, there has been increasing interest focusing on the cellular and molecular interactions between cancer cells and their microenvironment. HCC represents a unique opportunity to study the relationship between a diseased stroma and promotion of carcinogenesis, as 90 % of HCCs arise in a cirrhotic liver. Hepatic stellate cells (HSC) are the major source of extracellular proteins during fibrogenesis, and may directly, or via secreted products, contribute to tumour initiation and progression. In this review we explore the complex cellular and molecular interplay between HSC biology and hepatocarcinogenesis. We focus on the molecular mechanisms by which HSC modulate HCC growth, immune cell evasion and angiogenesis. This is followed by a discussion of recent progress in the field in understanding the mechanistic crosstalk between HSC and HCC, and the pathways that are potentially amenable to therapeutic intervention. Furthermore, we summarise the exciting recent developments in strategies to target HSC specifically, and novel techniques to deliver pharmaceutical agents directly to HSC, potentially allowing tailored, cell-specific therapy for HCC

Apport de l’endoscopie pour la décompression microvasculaire dans l’angle ponto-cérébelleux : à propos de 27 cas

Microvascular decompression is an important procedure for the management of microvascular compression syndromes in the cerebellopontine angle (CPA) like trigeminal neuralgia or hemifacial spasm. The ability to identify the offending vessel is the key to success. Can the endoscope help surgeons to identify and understand the responsible conflict in order to treat them? Our series concerns 27 consecutive patients who underwent microvascular decompression systematically using an endoscope with an angulation of 30° at the beginning and the end of the intervention. The decompression procedure was done under microscope. Endoscopic exploration was successful for all patients. Endoscopy improved visualization of the cranial nerves and allowed to see and understand the neurovascular conflicts, which were not able to be observed using the microscope alone for two of the 27 patients. The endoscope is a useful adjunct to microscopic exploration of the cranial nerves in the CPA avoiding significant cerebellar or brainstem retraction