Isoflavonoids Modified with Azole Heterocycles with Three Heteroatoms

Heterocycle modified chromones are attracting increasing attention as novel potential therapeutic agents due to their effective bioactivities and low toxicity. This review describes all strategies and versatile synthons that have been developed for the synthesis of isoflavone heterocyclic analogs containing isolated 5-member heterocyclic rings with three identical or different heteroatoms. Their biological activity is also presented

Hetarenocoumarins based on 7-hydroxy-3-(benzothiazol-2-yl)coumarin

The syntheses of angular hetarenocoumarins, namely chromeno[8,7-e][1,3]oxazin-2-ones and furo[2,3-h]chromen-2-one, have been accomplished starting from 7-hydroxy-3-(benzothiazol-2-yl)-coumarin using aminomethylation and formylation reactions