2 research outputs found
Patterns of ovarian morphology in polycystic ovary syndrome : a study utilising magnetic resonance imaging
Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (nβ=β44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (nβ=β40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2β9 mm in diameter and/or an ovarian volume greater than 10 cm3.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted Pβ=β1.3βΓβ10β16; calculated ovarian volume 8.8 cm3 [5.0, 15.5] vs 5.1 cm3 [2.5, 10.3], unadjusted Pβ=β3.0βΓβ10β7; peripheral follicle location in 55% vs 18% of ovaries, Pβ=β7.9βΓβ10β6; visible central ovarian stroma in 61% vs 24% of ovaries, Pβ=β2.3βΓβ10β5). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS