22 research outputs found
Electrochemically Generated Acid and Its Containment to 100 Micron Reaction Areas for the Production of DNA Microarrays
Get PDFAn addressable electrode array was used for the production of acid at sufficient concentration to allow deprotection of the dimethoxytrityl (DMT) protecting group from an overlaying substrate bound to a porous reaction layer. Containment of the generated acid to an active electrode of 100 micron diameter was achieved by the presence of an organic base. This procedure was then used for the production of a DNA array, in which synthesis was directed by the electrochemical removal of the DMT group during synthesis. The product array was found to have a detection sensitivity to as low as 0.5 pM DNA in a complex background sample
Building Addressable Libraries: Site-Selective Use of Pd(0) Catalysts on Microelectrode Arrays
No full textBuilding Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays
No full textBuilding Addressable Libraries: Site-Selective Suzuki Reactions on Microelectrode Arrays
No full textMoving Known Libraries to an Addressable Array: A Site-Selective Hetero-Michael Reaction
No full textSite-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays
No full textSite-Selective Chemistry and the Attachment of Peptides to the Surface of a Microelectrode Array
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