Crystallization characteristics of amorphous trehalose dried from alcohol

Trehalose forms a glass that can be used to preserve labile substances under desiccation. The crystallization characteristics, namely crystallization temperature (Tcry) and isothermal crystallization behavior of amorphous trehalose, dried from alcohol (methanol, ethanol), was analyzed and the results were compared with those for the amorphous trehalose freeze-dried from water. The use of alcohol as a solvent lowered the Tcry from 184 ± 6 °C for the case of an aqueous solvent to 103 ± 5 °C/methanol and 120 ± 8 °C/ethanol. The formation of multiple forms of crystals and partial melting were suggested by the thermal analysis. Isothermal crystallization experiments showed that the alcohol-originated amorphous trehalose was eventually exclusively converted into β-form crystals. The induction period (tind) before the start of isothermal crystallization was markedly shortened when alcohol was used as the solvent compared to water. The tind values for various amorphous sugar samples including the alcohol-originated ones could be correlated with difference between Tcry and the sample temperature

Impact of Bunch Current on Optics Measurements in SuperKEKB

SuperKEKB has recently achieved the world record instantaneous luminosity of 2.8 × 10³⁴ \si{cm⁻²s⁻¹} and aims at reaching a target luminosity of about 6 × 10³⁵ \si{cm⁻²s⁻¹}. To accomplish this goal it is planned to increase beam currents up to §I{3.6}{A} and §I{2.6}{A} for the positron and the electron ring, respectively. Increasing the beam currents and, in particular, the number of leptons per bunch, can impact the optics parameters obtained by turn-by-turn measurements, such as the betatron tune or phase advance. Optics measurements performed at various bunch currents can give first indications of possible intensity dependent effects. In this paper, the effect of varying bunch current on optics measurements at SuperKEKB is explored