14q12 translocation in a non-Burkitt lymphoma.

Chromosome analysis was performed on cells from a patient of null cell lymphoma, well-differentiated type. A 14q12 translocation was observed in all the banded cells. In addition, there were multiple chromosome abnormalities. This case will be useful in considering the significance of the 14q1(1-3) translocation in malignant lymphoma disease.</p

A Note on Kahler Potential of Charged Matter in F-theory

We study the Kahler potential of charged matter fields, whose profiles have a peak on their matter curve --- on an "intersection" of 7-branes, in an F-theory compactification. It is shown that the Kahler potential is exactly given by the integral over the matter curve, but not by the integral over the whole GUT surface of 7-branes.Comment: 15 pages; v2: typos correcte

Codimension-3 Singularities and Yukawa Couplings in F-theory

F-theory is one of the frameworks where all the Yukawa couplings of grand unified theories are generated and their computation is possible. The Yukawa couplings of charged matter multiplets are supposed to be generated around codimension-3 singularity points of a base complex 3-fold, and that has been confirmed for the simplest type of codimension-3 singularities in recent studies. However, the geometry of F-theory compactifications is much more complicated. For a generic F-theory compactification, such issues as flux configuration around the codimension-3 singularities, field-theory formulation of the local geometry and behavior of zero-mode wavefunctions have virtually never been addressed before. We address all these issues in this article, and further discuss nature of Yukawa couplings generated at such singularities. In order to calculate the Yukawa couplings of low-energy effective theory, however, the local descriptions of wavefunctions on complex surfaces and a global characterization of zero-modes over a complex curve have to be combined together. We found the relation between them by re-examining how chiral charged matters are characterized in F-theory compactification. An intrinsic definition of spectral surfaces in F-theory turns out to be the key concept. As a biproduct, we found a new way to understand the Heterotic--F theory duality, which improves the precision of existing duality map associated with codimension-3 singularities.Comment: 91 pages; minor clarification, typos corrected and a reference added (v3

Flavor Structure in F-theory Compactifications

F-theory is one of frameworks in string theory where supersymmetric grand unification is accommodated, and all the Yukawa couplings and Majorana masses of right-handed neutrinos are generated. Yukawa couplings of charged fermions are generated at codimension-3 singularities, and a contribution from a given singularity point is known to be approximately rank 1. Thus, the approximate rank of Yukawa matrices in low-energy effective theory of generic F-theory compactifications are minimum of either the number of generations N_gen = 3 or the number of singularity points of certain types. If there is a geometry with only one E_6 type point and one D_6 type point over the entire 7-brane for SU(5) gauge fields, F-theory compactified on such a geometry would reproduce approximately rank-1 Yukawa matrices in the real world. We found, however, that there is no such geometry. Thus, it is a problem how to generate hierarchical Yukawa eigenvalues in F-theory compactifications. A solution in the literature so far is to take an appropriate factorization limit. In this article, we propose an alternative solution to the hierarchical structure problem (which requires to tune some parameters) by studying how zero mode wavefunctions depend on complex structure moduli. In this solution, the N_gen x N_gen CKM matrix is predicted to have only N_gen entries of order unity without an extra tuning of parameters, and the lepton flavor anarchy is predicted for the lepton mixing matrix. We also obtained a precise description of zero mode wavefunctions near the E_6 type singularity points, where the up-type Yukawa couplings are generated.Comment: 148 page

Aclarubicin in the treatment of elderly patients with acute nonlymphocytic leukemia.

Thirteen previously untreated patients aged 70 and above with acute nonlymphocytic leukemia were treated with aclarubicin (ACR) alone. Among 10 cases (3, acute myelocytic leukemia; 4, acute myelomonocytic leukemia; 2, acute monocytic leukemia; and one, acute erythroleukemia) in which an evaluation was possible, 5 cases (3, acute myelomonocytic leukemia; and 2, acute monocytic leukemia) obtained complete remission (CR). The CR rate was 83% in 6 patients with acute myelomonocytic leukemia or acute monocytic leukemia. The median CR duration and survival was 7.5 and 10 + months, respectively. Although side effects of the drug on digestive system such as nausea, vomiting and anorexia were observed in all patients, they were controllable by conventional treatments. The results suggest that ACR is effective for the clinical management of elderly patients with acute nonlymphocytic leukemia, especially those with acute myelomonocytic leukemia or acute monocytic leukemia.</p