Control of broad-area vertical-cavity surface emitting laser emission by optically induced photonic crystals

We control the emission properties of a broad-area vertical-cavity surface emitting laser by coupling it to an external feedback cavity containing a photorefractive crystal with an optically induced photonic lattice. The periodic modulation of the refractive index serves as a tunable filter and enables the dynamic suppression of unwanted spatial instabilities and modes, as originally suggested by Gomila et al

Treatment responses in multidrug-resistant tuberculosis in Germany.

BACKGROUND: Excellent treatment outcomes have recently been reported for patients with multi/extensively drug-resistant tuberculosis (M/XDR-TB) in settings where optimal resources for individualised therapy are available. OBJECTIVE: To ascertain whether differences remain in treatment responses between patients with M/XDR-TB and those with non-M/XDR-TB. METHOD: Patients with TB were prospectively enrolled between March 2013 and March 2016 at five hospitals in Germany. Treatment was conducted following current guidelines and individualised on the basis of drug susceptibility testing. Two-month and 6-month sputum smear and sputum culture conversion rates were assessed. A clinical and radiological score were used to assess response to anti-tuberculosis treatment. RESULTS: Non-M/XDR-TB (n = 29) and M/XDR-TB (n = 46) patients showed similar rates of microbiological conversion: 2-month smear conversion rate, 90% vs. 78%; culture conversion rate, 67% vs. 61%; time to smear conversion, 19 days (IQR 10-32) vs. 31 days (IQR 14-56) (P = 0.066); time to culture conversion, 39 days (IQR 17-67) vs. 39 days (IQR 6-85) (P = 0.191). Both clinical and radiological scores decreased after the introduction of anti-tuberculosis treatment. CONCLUSION: There were no significant differences in scores between the two groups until 6 months of treatment. Under optimal clinical conditions, with the availability of novel diagnostics and a wide range of therapeutic options for individualised treatment, patients with M/XDR-TB achieved 6-month culture conversion rates that were compatible with those in patients with non-M/XDR-TB

Rendering dark modes bright by using asymmetric split ring resonators

We have studied both theoretically and experimentally symmetric and asymmetric planar metallic Split Ring Resonators. We demonstrate that introducing structural asymmetry makes it possible to excite several higher order modes of both even (l = 2) and odd (l = 3, 5) order, which are otherwise inaccessible for a normally incident plane wave in symmetric structures. Experimentally we observe that the even mode resonances of asymmetric resonators have a quality factor 5.8 times higher than the higher order odd resonances

Observation of double-charge discrete vortex solitons in hexagonal photonic lattices

We report on the experimental observation of stable double-charge discrete vortex solitons generated in hexagonal photonic lattices created optically in self-focusing nonlinear media and show that single-charge vortex solitons are unstable in analogous conditions. Subsequently, we study, both theoretically and experimentally, the existence and stability of spatial vortex solitons in two-dimensional hexagonal photonic lattices. We demonstrate that the stability of the double-charge vortices is a consequence of the intersite power exchange in the vortex soliton, and we provide a simple stability criterion on the basis of the analysis of the corresponding discrete nonlinear model. We extend our analysis to the case of defocusing nonlinearity and show the inversion of the vortex stability properties resulting in the fact that single-charge vortices become stable while their double-charge counterparts are unstable

Proteine: Sequenz, Struktur und Evolution (PROTAL). Teilprojekt: Protein-Evolution Abschlussbericht

The growing amount of data in biological databases can only be processed automatically. Our project aimed at contributing to this by designing, algorithmisation and implementation of relevant methods. For the reconstruction of phylogenetic relationships the splitdecomposition method was developed and realized in the computer program SPLITSTREE; for the fundamental problem of aligning sequences, two heuristics (DCA and DIALIGN) were implemented based on a divide-and-conquer principle and on a segment-to-segment-method, resp. All programs are available via the WorldWideWeb. The successful application of the methods developed here to certain instances, e.g. the family of basic helix-loop-helix proteins, show their importance for the above mentioned automation of the processing of large amounts of data. (orig.)SIGLEAvailable from TIB Hannover: DtF QN1(60,50) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman