A rare cause of ureteric stricture and hydronephrosis: metastatic esophageal cancer to the urinary bladder

The presence of hydronephrosis usually signifies the presence of significant urinary tract obstruction, more commonly at the level of the ureter, and occasionally at the bladder outlet in cases of bilateral hydronephrosis. Unilateral hydronephrosis is most commonly caused by a ureteric stone or stricture, and rarely caused by neoplasm. Metastatic disease to the urinary bladder is rare and usually presents with hematuria, and we report the first case of hydronephrosis resulting from a metastatic esophageal cancer to the bladder

Bioinspired bi-phasic 3D nanoflowers of MgO/Mg(OH)2 coated melamine sponge as a novel bactericidal agent

Abstract By roughly mimicking the surface architectural design of dragonfly wings, novel bi-phasic 3D nanoflowers of MgO/Mg(OH)2 were successfully synthesized via the electrospinning technique. The 3D nanoflowers were coated over a commercial melamine sponge and extensively characterized by SEM, XRD, FTIR, and EDS. The formation of distinct dense 3D nano petals was revealed by SEM images whereby the mean petal thickness and mean distance between the adjacent petals were found to be 36 nm and 121 nm, respectively. The bactericidal activities of synthesized 3D nano-flowers coated melamine sponges were assessed against five different bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa). This study demonstrated significant bactericidal activity of MgO/Mg(OH)2 3D nanoflowers coated MS against Gram-positive and Gram-negative bacteria. Plausible bactericidal mechanisms include envelope deformation, penetration, and induction of oxidative stress. This study introduces novel bioinspired biomaterial with the capacity to reduce the risk associated with pathogenic bacterial infections, especially in medical devices

Cost-effectiveness of MRI targeted biopsy strategies for diagnosing prostate cancer in Singapore

To evaluate the cost-effectiveness of six diagnostic strategies involving magnetic resonance imaging (MRI) targeted biopsy for diagnosing prostate cancer in initial and repeat biopsy settings from the Singapore healthcare system perspective.Published versio

Cost-effectiveness of MRI targeted biopsy strategies for diagnosing prostate cancer in Singapore

10.1186/s12913-021-06916-0BMC HEALTH SERVICES RESEARCH21