Majorana Fermions and Non-Abelian Statistics in Three Dimensions

We show that three dimensional superconductors, described within a Bogoliubov de Gennes framework can have zero energy bound states associated with pointlike topological defects. The Majorana fermions associated with these modes have non-Abelian exchange statistics, despite the fact that the braid group is trivial in three dimensions. This can occur because the defects are associated with an orientation that can undergo topologically nontrivial rotations. A new feature of three dimensional systems is that there are "braidless" operations in which it is possible to manipulate the groundstate associated with a set of defects without moving or measuring them. To illustrate these effects we analyze specific architectures involving topological insulators and superconductors.Comment: 4 pages, 2 figures, published versio

Evaluating the possibility of detecting evidence of positive selection across Asia with sparse genotype data from the HUGO Pan-Asian SNP Consortium

10.1186/1471-2164-15-332BMC Genomics151-BGME

Spin texture on the Fermi surface of tensile strained HgTe

We present ab initio and k.p calculations of the spin texture on the Fermi surface of tensile strained HgTe, which is obtained by stretching the zincblende lattice along the (111) axis. Tensile strained HgTe is a semimetal with pointlike accidental degeneracies between a mirror symmetry protected twofold degenerate band and two nondegenerate bands near the Fermi level. The Fermi surface consists of two ellipsoids which contact at the point where the Fermi level crosses the twofold degenerate band along the (111) axis. However, the spin texture of occupied states indicates that neither ellipsoid carries a compensating Chern number. Consequently, the spin texture is locked in the plane perpendicular to the (111) axis, exhibits a nonzero winding number in that plane, and changes winding number from one end of the Fermi ellipsoids to the other. The change in the winding of the spin texture suggests the existence of singular points. An ordered alloy of HgTe with ZnTe has the same effect as stretching the zincblende lattice in the (111) direction. We present ab initio calculations of ordered Hg_xZn_1-xTe that confirm the existence of a spin texture locked in a 2D plane on the Fermi surface with different winding numbers on either end.Comment: 8 pages, 8 figure

Global stabilization of switched control systems with time delay

In this paper, the stabilization problem of switched control systems with time delay is investigated for both linear and nonlinear cases. First, a new global stabilizability concept with respect to state feedback and switching law is given. Then, based on multiple Lyapunov functions and delay inequalities, the state feedback controller and the switching law are devised to make sure that the resulting closed-loop switched control systems with time delay are globally asymptotically stable and exponentially stable

Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS)

Càncer de bufeta; Rucaparib; Carcinoma urotelialCáncer de vejiga; Rucaparib; Carcinoma urotelialBladder cancer; Rucaparib; Urothelial carcinomaBackground ATLAS evaluated the efficacy and safety of the PARP inhibitor rucaparib in patients with previously treated locally advanced/unresectable or metastatic urothelial carcinoma (UC). Methods Patients with UC were enrolled independent of tumor homologous recombination deficiency (HRD) status and received rucaparib 600 mg BID. The primary endpoint was investigator-assessed objective response rate (RECIST v1.1) in the intent-to-treat and HRD-positive (loss of genome-wide heterozygosity ≥10%) populations. Key secondary endpoints were progression-free survival (PFS) and safety. Disease control rate (DCR) was defined post-hoc as the proportion of patients with a confirmed complete or partial response (PR), or stable disease lasting ≥16 weeks. Results Of 97 enrolled patients, 20 (20.6%) were HRD-positive, 30 (30.9%) HRD-negative, and 47 (48.5%) HRD-indeterminate. Among 95 evaluable patients, there were no confirmed responses. However, reductions in the sum of target lesions were observed, including 6 (6.3%) patients with unconfirmed PR. DCR was 11.6%; median PFS was 1.8 months (95% CI, 1.6–1.9). No relationship was observed between HRD status and efficacy endpoints. Median treatment duration was 1.8 months (range, 0.1–10.1). Most frequent any-grade treatment-emergent adverse events were asthenia/fatigue (57.7%), nausea (42.3%), and anemia (36.1%). Of 64 patients with data from tumor tissue samples, 10 (15.6%) had a deleterious alteration in a DNA damage repair pathway gene, including four with a deleterious BRCA1 or BRCA2 alteration. Conclusions Rucaparib did not show significant activity in unselected patients with advanced UC regardless of HRD status. The safety profile was consistent with that observed in patients with ovarian or prostate cancer.The work was supported by Clovis Oncology (no grant number) and was designed by the sponsor, P. Grivas, and S. Chowdhury

Dirac semimetal in three dimensions

In a Dirac semimetal, the conduction and valence bands contact only at discrete (Dirac) points in the Brillouin zone (BZ) and disperse linearly in all directions around these critical points. Including spin, the low energy effective theory around each critical point is a four band Dirac Hamiltonian. In two dimensions (2D), this situation is realized in graphene without spin-orbit coupling. 3D Dirac points are predicted to exist at the phase transition between a topological and a normal insulator in the presence of inversion symmetry. Here we show that 3D Dirac points can also be protected by crystallographic symmetries in particular space-groups and enumerate the criteria necessary to identify these groups. This reveals the possibility of 3D analogs to graphene. We provide a systematic approach for identifying such materials and present ab initio calculations of metastable \beta-cristobalite BiO_2 which exhibits Dirac points at the three symmetry related X points of the BZ.Comment: 6 pages, 4 figure

Geometric Phase in Eigenspace Evolution of Invariant and Adiabatic Action Operators

The theory of geometric phase is generalized to a cyclic evolution of the eigenspace of an invariant operator with $N$-fold degeneracy. The corresponding geometric phase is interpreted as a holonomy inherited from the universal connection of a Stiefel U(N)-bundle over a Grassmann manifold. Most significantly, for an arbitrary initial state, this geometric phase captures the inherent geometric feature of the state evolution. Moreover, the geometric phase in the evolution of the eigenspace of an adiabatic action operator is also addressed, which is elaborated by a pullback U(N)-bundle. Several intriguing physical examples are illustrated.Comment: Added Refs. and corrected typos; 4 page

Topological Defects and Gapless Modes in Insulators and Superconductors

We develop a unified framework to classify topological defects in insulators and superconductors described by spatially modulated Bloch and Bogoliubov de Gennes Hamiltonians. We consider Hamiltonians H(k,r) that vary slowly with adiabatic parameters r surrounding the defect and belong to any of the ten symmetry classes defined by time reversal symmetry and particle-hole symmetry. The topological classes for such defects are identified, and explicit formulas for the topological invariants are presented. We introduce a generalization of the bulk-boundary correspondence that relates the topological classes to defect Hamiltonians to the presence of protected gapless modes at the defect. Many examples of line and point defects in three dimensional systems will be discussed. These can host one dimensional chiral Dirac fermions, helical Dirac fermions, chiral Majorana fermions and helical Majorana fermions, as well as zero dimensional chiral and Majorana zero modes. This approach can also be used to classify temporal pumping cycles, such as the Thouless charge pump, as well as a fermion parity pump, which is related to the Ising non-Abelian statistics of defects that support Majorana zero modes.Comment: 27 pages, 15 figures, Published versio

Structure of Extremely Nanosized and Confined In-O Species in Ordered Porous Materials

Perturbed-angular correlation, x-ray absorption, and small-angle x-ray scattering spectroscopies were suitably combined to elucidate the local structure of highly diluted and dispersed InOx species confined in porous of ZSM5 zeolite. These novel approach allow us to determined the structure of extremely nanosized In-O species exchanged inside the 10-atom-ring channel of the zeolite, and to quantify the amount of In2O3 crystallites deposited onto the external zeolite surface.Comment: 4 pages, 5 postscript figures, REVTEX4, published in Physical Review Letter

SIC~POVMs and Clifford groups in prime dimensions

We show that in prime dimensions not equal to three, each group covariant symmetric informationally complete positive operator valued measure (SIC~POVM) is covariant with respect to a unique Heisenberg--Weyl (HW) group. Moreover, the symmetry group of the SIC~POVM is a subgroup of the Clifford group. Hence, two SIC~POVMs covariant with respect to the HW group are unitarily or antiunitarily equivalent if and only if they are on the same orbit of the extended Clifford group. In dimension three, each group covariant SIC~POVM may be covariant with respect to three or nine HW groups, and the symmetry group of the SIC~POVM is a subgroup of at least one of the Clifford groups of these HW groups respectively. There may exist two or three orbits of equivalent SIC~POVMs for each group covariant SIC~POVM, depending on the order of its symmetry group. We then establish a complete equivalence relation among group covariant SIC~POVMs in dimension three, and classify inequivalent ones according to the geometric phases associated with fiducial vectors. Finally, we uncover additional SIC~POVMs by regrouping of the fiducial vectors from different SIC~POVMs which may or may not be on the same orbit of the extended Clifford group.Comment: 30 pages, 1 figure, section 4 revised and extended, published in J. Phys. A: Math. Theor. 43, 305305 (2010