To investigate the morphological surface of Oasis wound dressing by atomic force microscopy (AFM) and scanning electron microscopy (SEM) techniques

In this dissertation, a morphological study on the surface of commercially available OasisTM Wound Dressing was carried out using atomic force microscopy (AFM) and scanning electron microscopy (SEM) techniques.Master of Science (Biomedical Engineering

The impact of free cash flow and dividend policy on stock abnormal returns.

Agency costs arise when both parties to a contract, under which there is delegation of authority for decision-making from the principal to the agent performing some service, are both utility-maximizers. Monitoring expenditures are incurred by the principal and bonding expenditures by the agent.Master of Business Administratio

Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow

Most craniofacial bones are derived from the ectodermal germ layer via neural crest stem cells, which are distinct from mesoderm-derived long bones. However, current craniofacial bone tissue engineering approaches do not account for this difference and utilize mesoderm-derived bone marrow mesenchymal stem cells (BM-MSCs) as a paradigm cell source. The effect of the embryonic origin (ontogeny) of an MSC population on its osteogenic differentiation potential and regenerative ability still remains unresolved. To clarify the effects of MSC ontogeny on bone regenerative ability, we directly compared the craniofacial bone regenerative abilities of an ecto-mesenchymal stem cell (eMSC) population, which is derived from human embryonic stem cells via a neural crest intermediate, with mesodermal adult BM-MSCs. eMSCs showed comparable osteogenic and chondrogenic ability to BM-MSCs in 2-D in vitro culture, but lower adipogenic ability. They exhibited greater proliferation than BM-MSCs and comparable construct mineralization in a well-established 3-D polycaprolactone-tricalcium phosphate (PCL-TCP) scaffold system in vitro. eMSC-derived 3D osteogenic constructs were maintained for longer in a proliferative osteoblast state and exhibited differential levels of genes related to fibroblast growth factor (FGF) signaling compared to BM-MSCs. Although both eMSC and BM-MSC-seeded scaffold constructs could promote bone regeneration in a rat calvarial defect model, eMSC-derived osseous constructs had significantly higher cellularity due to increased number of proliferative (Ki67+) cells than those seeded with BM-MSCs, and exhibited enhanced new bone formation in the defect area as compared to untreated controls. Overall, our study demonstrates the potential of human eMSCs for future clinical use in craniofacial regeneration applications and indicates the importance of considering MSC origin when selecting an MSC source for regenerative applications. </p

Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow

Most craniofacial bones are derived from the ectodermal germ layer via neural crest stem cells, which are distinct from mesoderm-derived long bones. However, current craniofacial bone tissue engineering approaches do not account for this difference and utilize mesoderm-derived bone marrow mesenchymal stem cells (BM-MSCs) as a paradigm cell source. The effect of the embryonic origin (ontogeny) of an MSC population on its osteogenic differentiation potential and regenerative ability still remains unresolved. To clarify the effects of MSC ontogeny on bone regenerative ability, we directly compared the craniofacial bone regenerative abilities of an ecto-mesenchymal stem cell (eMSC) population, which is derived from human embryonic stem cells via a neural crest intermediate, with mesodermal adult BM-MSCs. eMSCs showed comparable osteogenic and chondrogenic ability to BM-MSCs in 2-D in vitro culture, but lower adipogenic ability. They exhibited greater proliferation than BM-MSCs and comparable construct mineralization in a well-established 3-D polycaprolactone-tricalcium phosphate (PCL-TCP) scaffold system in vitro. eMSC-derived 3D osteogenic constructs were maintained for longer in a proliferative osteoblast state and exhibited differential levels of genes related to fibroblast growth factor (FGF) signaling compared to BM-MSCs. Although both eMSC and BM-MSC-seeded scaffold constructs could promote bone regeneration in a rat calvarial defect model, eMSC-derived osseous constructs had significantly higher cellularity due to increased number of proliferative (Ki67+) cells than those seeded with BM-MSCs, and exhibited enhanced new bone formation in the defect area as compared to untreated controls. Overall, our study demonstrates the potential of human eMSCs for future clinical use in craniofacial regeneration applications and indicates the importance of considering MSC origin when selecting an MSC source for regenerative applications. </p

International Comparison EURO.QM-S5 / 1166: Carbon Dioxide Mixtures in Nitrogen Final report

This supplementary comparison is designed to test the capabilities of the participants to measure and certify carbon dioxide in nitrogen, and to provide supporting evidence for the CMCs of institutes for carbon dioxide. Indeed this comparison aims to demonstrate the capabilities of IPQ in the production of primary gas mixtures of carbon dioxide in nitrogen and for the participant laboratories to demonstrate their capabilities on certifying primary gas mixtures of percent levels of carbon dioxide in nitrogen

An integrated command and control architecture concept for unmanned systems in the year 2030

U.S. Forces require an integrated Command and Control Architecture that enables operations of a dynamic mix of manned and unmanned systems. The level of autonomous behavior correlates to: 1) the amount of trust with the reporting vehicles, and 2) the multi-spectral perspective of the observations. The intent to illuminate the architectural issues for force protection in 2030 was based on a multi-phased analytical model of High Value Unit (HVU) defense. The results showed that autonomous unmanned aerial vehicles are required to defeat high-speed incoming missiles. To evaluate the level of autonomous behavior required for an integrated combat architecture, geometric distributions were modeled to determine force positioning, based on a scenario driven Detect-to-Engage timeline. Discrete event simulation was used to schedule operations, and a datalink budget assessment of communications to determine the critical failure paths in the the integrated combat architecture. The command and control principles used in the integrated combat architecture were based on Boyd's OODA (Obseve, Orient, Decide, and Act) Loop. A conservative fleet size estimate, given the uncertainties of the coverage overlap and radar detection range, a fleet size of 35 should be anticipated given an UAV detection range of 20km and radar coverage overlap of 4 seconds.http://archive.org/details/anintegratedcomm109455244US Navy (USN) authorsApproved for public release; distribution is unlimited

VIDEOGRAPHY Maisarah Abu Samah

republic polytechni