The Graphical Access Challenge for People with Visual Impairments: Positions and Pathways Forward

Graphical access is one of the most pressing challenges for individuals who are blind or visually impaired. This chapter discusses some of the factors underlying the graphics access challenge, reviews prior approaches to addressing this long-standing information access barrier, and describes some promising new solutions. We specifically focus on touchscreen-based smart devices, a relatively new class of information access technologies, which our group believes represent an exemplary model of user-centered, needs-based design. We highlight both the challenges and the vast potential of these technologies for alleviating the graphics accessibility gap and share the latest results in this line of research. We close with recommendations on ideological shifts in mindset about how we approach solving this vexing access problem, which will complement both technological and perceptual advancements that are rapidly being uncovered through a growing research community in this domain

Establishing Vibration-Based Tactile Line Profiles for Use in Multimodal Graphics

Vibration plays a significant role in the way users interact with touchscreens. For many users, vibration affords tactile alerts and other enhancements. For eyes-free users and users with visual impairments, vibration can also serve a more primary role in the user interface, such as indicating streets on maps, conveying information about graphs, or even specifying basic graphics. However, vibration is rarely used in current user interfaces beyond basic cuing. Furthermore, designers and developers who do actually use vibration more extensively are often unable to determine the exact properties of the vibration signals they are implementing, due to out-of-the-box software and hardware limitations. We make two contributions in this work. First, we investigate the contextual properties of touchscreen vibrations and how vibrations can be used to effectively convey traditional, embossed elements, such as dashes and dots. To do so, we developed an open source, Android-based library to generate vibrations that are perceptually salient and intuitive, improving upon existing vibration libraries. Second, we conducted a user study with 26 blind or visually impaired users to evaluate and categorize the effects with respect to traditional tactile line profiles. We have established a range of vibration effects that can be reliably generated by our haptic library and are perceptible and distinguishable by users

Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy

Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN binding protein 2 (RANBP2)–associated acute necrotizing encephalopathy subtype 1 (ANE1). We provide clinical, genetic, and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) confer susceptibility to a distinctive ANE subtype. This study aimed to evaluate clinical data, neuroradiological studies, genomic sequencing, and protein immunoblotting results in 8 children from 4 families who experienced acute febrile encephalopathy. All 8 healthy children became acutely encephalopathic during a viral/febrile illness and received a variety of immune modulation treatments. Long-term outcomes varied from death to severe neurologic deficits to normal outcomes. The neuroradiological findings overlapped with ANE but had distinguishing features. All affected children had biallelic predicted damaging variants in RNH1: a subset that was studied had undetectable RNH1 protein. Incomplete penetrance of the RNH1 variants was evident in 1 family. Biallelic variants in RNH1 confer susceptibility to a subtype of ANE (ANE2) in previously healthy children. Intensive immunological treatments may alter outcomes. Genomic sequencing in children with unexplained acute febrile encephalopathy can detect underlying genetic etiologies, such as RNH1, and improve outcomes in the probands and at-risk siblings