Comparison of crop water use efficiency with rotation and continuous cropping in an irrigated vertisol

Water use efficiency is a key issue for the Australian cotton industry. For the individual producer the focus is to maximise returns from a limited resource. However, the current debate on allocation of water between domestic, agricultural and environmental sectors, imposes additional significance to water use efficiency at the industry level. We are conducting a project that focuses on crop water use efficiency as a component of whole farm water use efficiency. This will be achieved by (i) identifying the current sources of variation in crop water use efficiency between production units and (ii) quantifying the contribution of rotation and tillage practices to the water use efficiency of irrigated or partially irrigated cotton crops. The aims are three fold..

G protein gamma subunit, a hidden master regulator of GPCR signaling

Heterotrimeric G proteins (αβγ subunits) that are activated by G protein-coupled receptors (GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α subunits and the tightly bound βγ subunit complex of G proteins have been extensively studied and shown to control the activity of effector molecules. In contrast, the potential roles of the large family of γ subunits have been less studied. In this review, we focus on present knowledge about these proteins. Induced loss of individual γ subunit types in animal and plant models result in strikingly distinct phenotypes indicating that γ subtypes play important and specific roles. Consistent with these findings, downregulation or upregulation of particular γ subunit types result in various types of cancers. Clues about the mechanistic basis of γ subunit function have emerged from imaging the dynamic behavior of G protein subunits in living cells. This shows that in the basal state, G proteins are not constrained to the plasma membrane but shuttle between membranes and on receptor activation βγ complexes translocate reversibly to internal membranes. The translocation kinetics of βγ complexes varies widely and is determined by the membrane affinity of the associated γ subtype. On translocating, some βγ complexes act on effectors in internal membranes. The variation in translocation kinetics determines differential sensitivity and adaptation of cells to external signals. Membrane affinity of γ subunits is thus a parsimonious and elegant mechanism that controls information flow to internal cell membranes while modulating signaling responses

Individual information security, user behaviour and cyber victimisation: An empirical study of social networking users

While extant literature on privacy in social networks is plentiful, issues pertaining to information security remain largely unexplored. This paper empirically examines the relationship between online victimisation and users' activity and perceptions of personal information security on social networking services (SNS). Based on a survey of active users, we explore how behavioural patterns on social networks, personal characteristics and technical efficacy of users impact the risk of facing online victimisation. Our results suggest that users with high-risk propensity are more likely to become victims of cybercrime, whereas those with high perceptions of their ability to control information shared on SNS are less likely to become victims. The study shows that there is a negative and statistically significant association between multipurpose dominant SNS (e.g. Facebook, Google +) usage and victimisation. However, activity on the SNS for knowledge exchange (e.g. LinkedIn, Blogger) has a positive and statistically significant association with online victimisation. Our results have implications for practice as they inform the social media industry that protection of individual information security on SNS cannot be left entirely to the user. The importance of user awareness in the context of social technologies plays an important role in preventing victimisation, and social networking services should provide adequate controls to protect personal information

Awareness and utilization of HIV testing and prevention services among female sex workers in Dnipro, Ukraine: implications for prevention program strengthening from the dynamics study

INTRODUCTION: Approximately 240,000 people live with HIV in Ukraine, concentrated among key populations, including sex workers. Non-governmental organizations (NGOs) play an important role in the funding and delivery of HIV testing and prevention services in Ukraine. These services are set within the context of national healthcare reforms as well as ongoing armed conflict. This study seeks to describe and understand the usage of HIV testing and prevention services among sex workers in the eastern Ukrainian city of Dnipro. METHODS: A cross-sectional bio-behavioral survey was administered in September 2017-March 2018 among 560 sex workers working in Dnipro. Descriptive analyses of survey data are presented alongside multivariable logistic regression models identifying factors associated with NGO awareness and HIV testing in the past 12 months; adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) are reported. RESULTS: Sixty-two percent of respondents were aware of NGOs offering HIV services. Sixty-eight percent had tested for HIV in the past 12 months, and 51% of those who reported the location of their most recent test were tested at an NGO. Those with 5-9 years in sex work had greater odds of being aware of NGOs (AOR = 5.5, 95%CI: 3.2-9.7) and testing for HIV (AOR = 3.4, 95%CI: 2.0-6.0) compared to those new to the profession. Contact with outreach workers was strongly associated with increased odds of testing (AOR = 13.0, 95%CI: 7.0-24.0). Sex workers in "offices" (brothel-like venues) reported higher odds of testing than all other workplaces, while those in entertainment venues (AOR = 0.3, 95%CI: 0.2-0.5) and public places (AOR = 0.2, 95%CI: 0.1-0.3) reported lower rates. Receiving prevention services, such as free condoms, was associated with increased testing (AOR = 16.9, 95%CI: 9.7-29.3). DISCUSSION: NGOs in Dnipro, Ukraine play an important role in HIV testing and prevention for women involved in sex work. However, focused efforts should be placed on supporting access to these services for women that are newer to sex work, and those working in entertainment venues or public places. Outreach workers appear to support access to HIV prevention information and supplies and facilitate linkages to HIV testing for sex workers

Analysis of impacts of climate variability on malaria transmission in Sri Lanka and the development of an early warning system

This project set goals of bringing together a multi-disciplinary, multi-national and multi-institutional team to address the relationship between climate and malaria in aggregate terms for Sri Lanka, and in detail for the Uva Province to help develop early warning systems. The project was undertaken in partnership with Sri Lanka’s Anti-Malaria Campaign (AMC) and the Foundation for Environment, Climate and Technology, Sri Lanka (FECT). Overall, we have accomplished the projected outcomes in spite of several setbacks

LEAF ADAPTABILITY OF lWO NON·TIMBER FOREST SPECIES Caryota urens L. AND Elettaria carrlamomum VAR. MAJOR PLANTED IN THE Pinus caribaea ENRICHMENT BUFFER ZONE IN SINHARAJA MAB RESERVE, SRI LANKA

Caryota urens L. and Elettaria cardamomum var. major are indigenous non-timberspecies which are used as market or sustainable goods and services for human orindustrial consumption. Both species thrive well in disturbed forest areas in the southwesternpart of Sri Lanka. Being understorey species, the growth of these species areaffected by sun light which is highly variable and often limiting resource in the forest.In a Pinus enrichment study established in 1991, leaf anatomical adaptability of these twospecies after 12 years of initial establishment under the Pinus buffer zone of the SinharajaMAB .reserve was investigated. Different light levels in the study area were created bythinning Pinus trees at different densities.Lower epidermis of C. urens showed highest (7.75 %) and lowest (6.35 %) stomatalindices in 2 pine rows removed treatment (2R) and 5 pine rows removed treatment (5R)respectively. Corresponding values for E. cardamomum were 6.00 % (highest) in theclosed canopy control (CU) and 5.22 % (lowest) in 1 pine row removed treatment (lR).The highest thickness of C. urens leaf cuticle (0.2611 ±0.02), leaf blade (22.2711 ±2.l4),upper epidermis (1.7511 ±0.10), lower epidermis (1.8311 ±0.06), palisade layer (6.2511±0.87) and spongy mesophylliayer (11.7411 ±1.30) were observed in 5R treatment thatreceived relatively high light levels than other treatments.E. cardamomum leaves showed highest thickness of leaf blade (22.4311 ±O.88), lowerepidermal layer (2.1211 ±O.ll), spongy mesophyll layer (10.3211 ±O.57) in 3 pine rowsremoved treatment (3R). The highest cuticle thickness (0.2311 ±O.OI) was recordered in 3pine rows under planting treatment (3U) while lR treatment showed highest upperepidermal layer thickness of 2.2111 ±0.15. Palisade layer was highest (4.74J! ±0.55) inCU.Results revealed that C. urens shows leaf adaptability to grow under relatively high sunlight levels (5R treatment) while E. cardamomum shows most of the leaf adaptabilitycharacters to grow under moderate light levels (3R treatment).The knowledge gained by this study is useful to recommend the optimum lightrequirements in terms of leaf anatomical traits of the study species.

International Research Institute for Climate and Society

Contemporary ecological research supports focus on the preservation of habitats and the preservation of keystone species that are critical to the ecological character of the habitats. Conservation of endangered species works best with attention not only to the species but also to the needs of the people who may be adjacent to or bordering habitats. Southern Sri Lanka fall into the category of globally important biodiversity hotspots. The biggest land animal, the elephant is the keystone species in Sri Lanka outside the highlands. The population of elephants in Sri Lanka is estimated to be between 3000 and 4,000; yet there has been an alarming loss of 1000 elephants during from 1990-2003. Given its island setting and rich hydro-climatic data, Sri Lanka provides a unique opportunity to study the dynamics leading to species loss. Our work in this project was initially motivated by the practical concerns of our project partners in the Mahaweli River Basin in Sri Lanka where the human-elephant conflict was a major problem. The question that arose was: “Are the climate, water availability and river basin management practices contributing to conflict between elephants and people?” If this was indeed the case, then, could one adaptively manage the river basin, organize agricultural practices, and prioritize conflict mitigation options such as separate habitat enrichment programs? Moreover, could we propose various adaptive measures in changes if one could monitor the climate and environmental conditions and take advantage of seasonal climate predictions

Patterns and Collective Behavior in Granular Media: Theoretical Concepts

Granular materials are ubiquitous in our daily lives. While they have been a subject of intensive engineering research for centuries, in the last decade granular matter attracted significant attention of physicists. Yet despite a major efforts by many groups, the theoretical description of granular systems remains largely a plethora of different, often contradicting concepts and approaches. Authors give an overview of various theoretical models emerged in the physics of granular matter, with the focus on the onset of collective behavior and pattern formation. Their aim is two-fold: to identify general principles common for granular systems and other complex non-equilibrium systems, and to elucidate important distinctions between collective behavior in granular and continuum pattern-forming systems.Comment: Submitted to Reviews of Modern Physics. Full text with figures (2Mb pdf) avaliable at http://mti.msd.anl.gov/AransonTsimringReview/aranson_tsimring.pdf Community responce is appreciated. Comments/suggestions send to [email protected]

Neurotoxicity with high dose disulfiram and vorinostat used for HIV latency reversal

OBJECTIVE: To examine whether administering both vorinostat and disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is safe and can enhance HIV latency reversal. DESIGN: Vorinostat and disulfiram, can increase HIV transcription in people with HIV (PWH) on antiretroviral therapy (ART). Together these agents may lead to significant HIV latency reversal. METHODS: Virologically suppressed PWH on ART received disulfiram 2000 mg daily for 28 days and vorinostat 400 mg daily on days 8-10 and 22-24. The primary endpoint was plasma HIV RNA on day 11 relative to baseline using a single copy assay. Assessments included cell-associated (CA) unspliced (US) RNA as a marker of latency reversal, HIV DNA in CD4+ T-cells, plasma HIV RNA and plasma concentrations of ART, vorinostat and disulfiram. RESULTS: The first two participants (P1 and P2) experienced grade 3 neurotoxicity leading to trial suspension. After 24 days, P1 presented with confusion, lethargy, and ataxia having stopped disulfiram and ART. Symptoms resolved by day 29. After 11 days, P2 presented with paranoia, emotional lability, lethargy, ataxia and study drugs were ceased. Symptoms resolved by day 23. CA-US RNA increased by 1.4- and 1.3-fold for P1 and P2 respectively. Plasma HIV RNA was detectable from day 8-37 (peak 81 copies/mL) for P2 but was not increased in P1 Antiretroviral levels were therapeutic and neuronal injury markers were elevated in P1. CONCLUSIONS: The combination of prolonged high dose disulfiram and vorinostat was not safe in PWH on ART and should not be pursued despite evidence of latency reversal

Sustainable development through proper land utilization Case study Ratnapura, Sri Lanka

Since the land is a scarce resource, the utilization of land effectively would be directly affected to thesustainable development of any country. A proper system ofland uti Iization is very essential especiallyfor a country like Sri Lanka which is very small in size and the majority of the people are dependingon the land related activities such as farming, grazing etc. as their major source of income. Unfortunately,land is in the state of under utilization in Sri Lanka. This paper attempts to study the importance of theeffective land utilization using Geographical Information Systems (GIS) for the sustainable development.The study was mainly based on the data gathered from Ratnapura Divisional Secretary area, Thearea is consisting with natural vegetations such as forests, shrubs. and man -rnade cultivation such astea, rubber, paddy. Also the area has a high economic value and it is well known for natural disasterssuch as floods and earth slips. Primary data was collected using semi-structured questionnaires,interviewing people and relevant officers and field surveying using hand held Global Positioning System(GPS). The study supplemented with secondary data such as remote sensing satellite images, existingmaps. GIS technique was used for the data analyses.The study identified 4 major issues in the specified areaI. 20 % of the total area is under utilization2. 25 % of the total area is misused3. 05 % of the total area is over utilized4. Continuous loss of land due to the natural disastersAccording to the results, the land has not used effectively in the area. 45% of the area is not usedeffectively. Since the country is very small, proper land utilization is very important. The study suggestthat an immediate action should be taken to overcome the matter. And also it is very important to getthe active participation of the general public to stop the loss ofland due to natural disasters and forfuture decision making.