Ethnic discordance in serum anti-Müllerian hormone in healthy women: a population study from China and Europe

Research question: Chinese women are known to have an earlier age of natural menopause than their European counterparts, but whether they also have a lower functional ovarian reserve is unknown. This study was designed to assess whether there are ethnic differences in anti-Müllerian hormone (AMH) concentrations in women of reproductive age. Design: Women in China and Europe with regular menstrual cycles, not on hormonal contraception and with no medical history of note, were recruited to provide a day 2–5 early follicular phase sample. AMH concentration was determined using the Roche Elecsys assay. Decline in AMH was modelled with linear, quadratic and quadratic with interaction on age equations to assess the impact of ethnicity. Results: A total of 887 European and 461 Chinese women participated in the study. Despite the Chinese population being slightly younger (34.1 ± 8.4 years) than their European counterparts (34.8±8.9 years), their median AMH was lower, at 1.87 ng/ml (interquartile range [IQR] 0.28–3.64) compared with 2.11 ng/ml (IQR 0.73–3.96), with evidence of increasing discordance from age 25 years. In all regression models of the age-related decline in AMH, there was evidence of a difference between Chinese and European women. Although AMH was 28.1% (95% confidence interval [CI] 18.2–36.7%) lower in the Chinese population at age 30, this decline increased to 79.4% (95% CI 75.4– 82.9%) at age 45. Conclusions: There were independent effects of age and ethnicity on serum AMH concentrations, with Chinese women having a substantially lower AMH in adult life than their European counterparts from age 25 onwards

Ultra-High Frequency Nano-mechanical Resonator with Graphene/Graphene Oxide Doubly Clamped Beam

The remarkable properties of graphene have renewed interest in ultra-high frequency nano-electromechanical systems (NEMS) with extraordinary mechanical and electronic attributes. However, the resonant frequency of graphene NEMS is still under 300MHz at room temperature. To further increase the resonator frequency, this paper presents an ultra-high frequency nano-mechanical resonator by using graphene/graphene oxide (G/GO) doubly clamped beam.The results show that the resonator frequency of G/GO nanomechanical resonator can reach up to 350.2MHz

Improving the Detection Accuracy of Underwater Obstacles Based on a Novel Combined Method of Support Vector Regression and Gravity Gradient

Underwater gravity gradient detection techniques are conducive to ensuring the safety of submersible sailing. In order to improve the accuracy of underwater obstacle detection based on gravity gradient detection technology, this paper studies the gravity gradient underwater obstacle detection method based on the combined support vector regression (SVR) algorithm. First, the gravity gradient difference ratio (GGDR) equation, which is only related to the obstacle’s position, is obtained based on the gravity gradient equation by using the difference and ratio methods. Aiming at solving the shortcomings of the GGDR equation based on Newton–Raphson method (NRM), combined with SVR algorithm, a novel SVR–gravity gradient joint method (SGJM) is proposed. Second, the differential ratio dataset is constructed by simulating the gravity gradient data generated by obstacles, and the obstacle location model is trained using SVR. Four measuring lines were selected to verify the SVR-based positioning model. The verification results show that the mean absolute error of the new method in the x, y, and z directions is less than 5.39 m, the root-mean-square error is less than 7.58 m, and the relative error is less than 4% at a distance of less than 500 m. These evaluation metrics validate the reliability of the novel SGJM-based detection of underwater obstacles. Third, comparative experiments based on the novel SGJM and traditional NRM were carried out. The experimental results show that the positioning accuracy of x and z directions in the obstacle’s position calculation based on the novel SGJM is improved by 88% and 85%, respectively

Frequency Tuning of Graphene Nanoelectromechanical Resonators via Electrostatic Gating

In this article, we report on a comprehensive modeling study of frequency tuning of graphene resonant nanoelectromechanical systems (NEMS) via electrostatic coupling forces induced by controlling the voltage of a capacitive gate. The model applies to both doubly clamped graphene membranes and circumference-clamped circular drumhead device structures. Frequency tuning of these devices can be predicted by considering both capacitive softening and elastic stiffening. It is shown that the built-in strain in the device strongly dictates the frequency tuning behavior and tuning range. We also find that doubly clamped graphene resonators can have a wider frequency tuning range, while circular drumhead devices have higher initial resonance frequency with same device characteristic parameters. Further, the parametric study in this work clearly shows that a smaller built-in strain, smaller depth of air gap or cavity, and larger device size or characteristic length (e.g., length for doubly clamped devices, and diameter for circular drumheads) help achieve a wider range of electrostatic frequency tunability. This study builds a solid foundation that can offer important device fabrication and design guidelines for achieving radio frequency components (e.g., voltage controlled oscillators and filters) with the desired frequencies and tuning ranges

Enhanced adsorption of trivalent arsenic from water by functionalized diatom silica shells.

The potential of porous diatom silica shells as a naturally abundant low-cost sorbent for the removal of arsenic in aqueous solutions was investigated in a batch study. The objective of this work was to chemically modify the silica shells of a diatom Melosira sp. with bifunctional (thiol and amino) groups to effectively remove arsenic in its toxic As(III) form (arsenite) predominant in the aquatic environment. Sorption experiments with this novel sorbent were conducted under varying conditions of pH, time, dosage, and As(III) concentration. A maximum adsorption capacity of 10.99 mg g-1 was achieved within 26 h for a solution containing 12 mg L-1 As(III) at pH 4 and sorbent dosage of 2 g L-1. The functionalized diatom silica shells had a surface morphological change which was accompanied by increased pore size at the expense of reduced specific surface area and total pore volume. As(III) adsorption was best fitted with the Langmuir-Freundlich model, and the adsorption kinetic data using pore surface diffusion model showed that both the external (film) and internal (intraparticle) diffusion can be rate-determining for As(III) adsorption. Fourier transform infrared spectroscopy (FTIR) indicated that the thiol and amino groups potentially responsible for As(III) adsorption were grafted on the surface of diatom silica shells. X-ray photoelectron spectroscopy (XPS) further verified that this unique sorbent proceeded via a chemisorption mechanism through the exchange between oxygen-containing groups of neutral As(III) and thiol groups, and through the surface complexation between As(III) and protonated nitrogen and hydroxyl groups. Results indicate that this functionalized bioadsorbent with a high As(III) adsorption capacity holds promise for the treatment of As(III) containing wastewater

Biomimetic Superhydrophobic Films with an Extremely Low Roll-Off Angle Modified by F16CuPc via Two-Step Fabrication

Superhydrophobicity is the phenomenon of which the water contact angle (WCA) of droplets on a solid surface is greater than 150°. In the present paper, we prepare a superhydrophobic film with a structure similar to the surface of a lotus leaf, which is composed of polydimethylsiloxane (PDMS), zinc oxide (ZnO), a molecular sieve (MS) and 1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-hexadecafluorophthalocyanine copper(II) (F16CuPc). The F16CuPc was used as the modifier to reduce the surface energy of the biomimetic micro-nanostructure. With the introduction of F16CuPc, the superhydrophobic properties of the surface were enhanced so that the WCA and water roll-off angle could reach 167.1° and 0.5°, respectively. Scanning electron microscopy, X-ray energy spectrometry, and X-ray photoelectron spectroscopy analyses verified that the enhanced superhydrophobic properties of the film were mainly attributed to the modification of F16CuPc. Finally, thermal, mechanical, and chemical stability studies, as well as the influences of UV and underwater immersion on the superhydrophobic film were investigated. This developed two-step fabrication method may be a potential direction for superhydrophobic surface fabrication due to its simple process, excellent superhydrophobic property, and favorable stability