Value of thermostatic loads in future low-carbon Great Britain system

This paper quantifies the value of a large population of heterogeneous thermostatically controlled loads (TCLs). The TCL dynamics are regulated by means of an advanced demand side response model (DSRM). It optimally determines the flexible energy/power consumption and simultaneously allocates multiple ancillary services. This model explicitly incorporates the control of dynamics of the TCL recovery pattern after the provision of the selected services. The proposed framework is integrated in a mixed integer linear programming formulation for a multi-stage stochastic unit commitment. The scheduling routine considers inertia-dependent frequency response requirements to deal with the drastic reduction of system inertia under future low-carbon scenarios. Case studies focus on the system operation cost and CO2 emissions reductions for individual TCLs for a) different future network scenarios, b) different frequency requirements, c) changes of TCL parameters (e.g. coefficient of performance, thermal insulation etc.)

Benefits of demand-side response in providing frequency response service in the future GB power system

The demand for ancillary service is expected to increase significantly in the future Great Britain (GB) electricity system due to high penetration of wind. In particular, the need for frequency response, required to deal with sudden frequency drops following a loss of generator, will increase because of the limited inertia capability of wind plants. This paper quantifies the requirements for primary frequency response and analyses the benefits of frequency response provision from demand-side response (DSR). The results show dramatic changes in frequency response requirements driven by high penetration of wind. Case studies carried out by using an advanced stochastic generation scheduling model suggest that the provision of frequency response from DSR could greatly reduce the system operation cost, wind curtailment, and carbon emissions in the future GB system characterized by high penetration of wind. Furthermore, the results demonstrate that the benefit of DSR shows significant diurnal and seasonal variation, whereas an even more rapid (instant) delivery of frequency response from DSR could provide significant additional value. Our studies also indicate that the competing technologies to DSR, namely battery storage, and more flexible generation could potentially reduce its value by up to 35%, still leaving significant room to deploy DSR as frequency response provider

A Supernova Factory in the Merger System Arp 299

We have imaged the nearby galaxy merger Arp 299 at arcsecond and milliarcsecond resolution, using both the Very Large Array and the Very Long Baseline Array. The large-scale radio emission from the merger contains 5 bright, compact radio sources embedded in diffuse emission, with diameters less than 200 pc. Supernova rates of 0.1 to 1 per year are required to produce the VLA-detected radio emission in these sources. Two of the compact VLA radio sources, designated Source A and Source D, also have been detected and imaged at milliarcsecond scales. Source A, which is associated with the nucleus of one of the merging galaxies, contains five milliarcsecond-scale sources, each with a radio power between 100 and 1000 times that of the Galactic supernova remnant Cassiopeia A. Four of these have flat or inverted spectra and appear to be young supernovae. Three of the VLBI-scale sources are located within 10 pc (projected) of one another, and two are separated by less than 3 pc, indicating that they all may be within the same super starcluster or complex of such clusters. The brightest VLBI-scale source, A0, has an extremely inverted pectrum, with alpha larger than +2 at gigahertz frequencies. It seems to be the youngest supernova, which has not yet broken out of its circumstellar shell. The milliarcsecond radio sources within Source A appear to constitute a upernova factory, confirming the presence of an extreme starburst that peaked at least a few million years ago.Comment: Accepted for the Astrophysical Journal, 22 pages, 10 figure

Challenges of Primary Frequency Control and Benefits of Primary Frequency Response Support from Electric Vehicles

As the integration of wind generation displaces conventional plants, system inertia provided by rotating mass declines, causing concerns over system frequency stability. This paper implements an advanced stochastic scheduling model with inertia-dependent fast frequency response requirements to investigate the challenges on the primary frequency control in the future Great Britain electricity system. The results suggest that the required volume and the associated cost of primary frequency response increase significantly along with the increased capacity of wind plants. Alternative measures (e.g. electric vehicles) have been proposed to alleviate these concerns. Therefore, this paper also analyses the benefits of primary frequency response support from electric vehicles in reducing system operation cost, wind curtailment and carbon emissions

Metabolism of ticagrelor in patients with acute coronary syndromes.

© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its antiplatelet action. Still, ticagrelor is extensively metabolized by hepatic CYP3A enzymes, and AR-C124910XX is its only active metabolite. A post hoc analysis of patient-level (n = 117) pharmacokinetic data pooled from two prospective studies was performed to identify clinical characteristics affecting the degree of AR-C124910XX formation during the first six hours after 180 mg ticagrelor loading dose in the setting of ACS. Both linear and multiple regression analyses indicated that ACS patients presenting with ST-elevation myocardial infarction or suffering from diabetes mellitus are more likely to have decreased rate of ticagrelor metabolism during the acute phase of ACS. Administration of morphine during ACS was found to negatively influence transformation of ticagrelor into AR-C124910XX when assessed with linear regression analysis, but not with multiple regression analysis. On the other hand, smoking appears to increase the degree of ticagrelor transformation in ACS patients. Mechanisms underlying our findings and their clinical significance warrant further research.Peer reviewedFinal Published versio

Experimental behaviour of FRP-confined large-scale curvilinearized rectangular RC columns under axial compression

Existing research has shown that strengthening through fibre-reinforced polymer (FRP) confinement is highly effective for circular columns but much less so for sTuare and rectangular columns due to the flat sides and sharp corners in the latter. Rounding the corners in the latter columns can enhance the effectiveness of confinement, but its benefit is limited. To overcome this problem, an alternative strengthening techniTue has recently been proposed by some researchers, in which the flat sides of a sTuarerectangular section are modified into slightly curved sides before FRP confinement (referred to as section curvilinearization). The resulting columns, referred to as curvilinearized sTuare rectangular columns, are much more effectively confined by an FRP jacket than the original sTuarerectangular columns with only corner rounding, and the associated column size increase is limited. While this section curvilinearization techniTue is highly attractive, there has been only very limited research on the behaviour of FRP-confined curvilinearized sTuare rectangular columns. In particular, all the existing experimental work has been limited to small-scale sTuare columns (with section widths being around or below 1 mm) under axial compression. Against the above background, a large experimental programme has been under way at The Hong Kong Polytechnic University to study the behaviour of large-scale curvilinearized RC columns under both concentric and eccentric compression. Both sTuare and rectangular columns have been considered in the experimental programme. This paper presents a systematic experimental study on the behaviour of FRP-confined curvilinearized rectangular RC columns under axial compression to study the effects of the following parameters: rise-to-span ratio of the edge profile, sectional aspect ratio and corner radius. In addition to the presentation of experimental results, two existing stress-strain models for FRP-confined concrete in these columns are assessed to reveal their limitations

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome Atlas (TCGA), and we identified 119 splicing factor genes with significant non-silent mutation patterns, including mutation over-representation, recurrent loss of function (tumor suppressor-like), or hotspot mutation profile (oncogene-like). Furthermore, RNA sequencing analysis revealed altered splicing events associated with selected splicing factor mutations. In addition, we were able to identify common gene pathway profiles associated with the presence of these mutations. Our analysis suggests that somatic alteration of genes involved in the RNA-splicing process is common in cancer and may represent an underappreciated hallmark of tumorigenesis