Atlas construction and image analysis using statistical cardiac models

International audienceThis paper presents a brief overview of current trends in the construction of population and multi-modal heart atlases in our group and their application to atlas-based cardiac image analysis. The technical challenges around the construction of these atlases are organized around two main axes: groupwise image registration of anatomical, motion and fiber images and construction of statistical shape models. Application-wise, this paper focuses on the extraction of atlas-based biomarkers for the detection of local shape or motion abnormalities, addressing several cardiac applications where the extracted information is used to study and grade different pathologies. The paper is concluded with a discussion about the role of statistical atlases in the integration of multiple information sources and the potential this can bring to in-silico simulations

The magellan-tess survey. i. survey description and midsurvey results*

Kepler revealed that roughly one-third of Sunlike stars host planets orbiting within 100 days and between the size of Earth and Neptune. How do these planets form, what are they made of, and do they represent a continuous population or multiple populations? To help address these questions, we began the Magellan-TESS Survey (MTS), which uses Magellan II/PFS to obtain radial velocity (RV) masses of 30 TESS-detected exoplanets and develops an analysis framework that connects observed planet distributions to underlying populations. In the past, smallplanet RV measurements have been challenging to obtain due to host star faintness and low RV semiamplitudes and challenging to interpret due to the potential biases in target selection and observation planning decisions. The MTS attempts to minimize these biases by focusing on bright TESS targets and employing a quantitative selection function and observing strategy. In this paper, we (1) describe our motivation and survey strategy, (2) present our first catalog of planet density constraints for 27 TESS Objects of Interest (TOIs; 22 in our population analysis sample, 12 that are members of the same systems), and (3) employ a hierarchical Bayesian model to produce preliminary constraints on the mass-radius (M-R) relation. We find that the biases causing previous M-R relations to predict fairly high masses at 1 R have been reduced. This work can inform more detailed studies of individual systems and offer a framework that can be applied to future RV surveys with the goal of population inferences

Biosafety of Recombinant Adeno-associated Virus Vectors.

It is hoped that the use of gene transfer technology to treat both monogenetic and acquired diseases may soon become a common therapy option in medicine. For gene therapy to achieve this objective, any gene delivery method will have to meet several criteria, including ease of manufacturing, efficient gene transfer to target tissue, long-term gene expression to alleviate the disease, and most importantly safety in patients. Viral vectors are an attractive choice for use in gene therapy protocols due to their relative efficiency in gene delivery. Since there is inherent risk in using viruses, investigators in the gene therapy community have devoted extensive efforts toward reengineering viral vectors for enhance safety. Here we review the approaches and technologies that are being evaluated for the use of recombinant vectors based upon adeno-associated virus (AAV) in the treatment of a variety of human diseases. AAV is currently the only known human DNA virus that is non-pathogenic and AAV-based vectors are classified as Risk Group 1 agents for all laboratory and animal studies carried out in the US. Although its apparent safety in natural infection and animals appears well documented, we examine the accumulated knowledge on the biology and vectorology of AAV, lessons learned from gene therapy clinical trials, and how this information is impacting current vector design and manufacturing with an overall emphasis on biosafety