Cannabis use and anxiety: is stress the missing piece of the puzzle?

OBJECTIVE Comorbidity between anxiety and cannabis use is common yet the nature of the association between these conditions is not clear. Four theories were assessed, and a fifth hypothesis tested to determine if the misattribution of stress symptomology plays a role in the association between state-anxiety and cannabis. METHODS Three-hundred-sixteen participants ranging in age from 18 to 71 years completed a short online questionnaire asking about their history of cannabis use and symptoms of stress and anxiety. RESULTS Past and current cannabis users reported higher incidence of lifetime anxiety than participants who had never used cannabis; however, these groups did not differ in state-anxiety, stress, or age of onset of anxiety. State-anxiety and stress were not associated with frequency of cannabis use, but reported use to self-medicate for anxiety was positively associated with all three. Path analyses indicated two different associations between anxiety and cannabis use, pre-existing and high state-anxiety was associated with (i) higher average levels of intoxication and, in turn, acute anxiety responses to cannabis use; (ii) frequency of cannabis use via the mediating effects of stress and self-medication. CONCLUSION None of the theories was fully supported by the findings. However, as cannabis users reporting self-medication for anxiety were found to be self-medicating stress symptomology, there was some support for the stress-misattribution hypothesis. With reported self-medication for anxiety being the strongest predictor of frequency of use, it is suggested that researchers, clinicians, and cannabis users pay greater attention to the overlap between stress and anxiety symptomology and the possible misinterpretation of these related but distinct conditions

Validation of Geant4 upgrade to model response from muons passing through the KLM detector at the Belle II experiment.

The KLM detector or K0L- Muon Detector is equipped on the outermost layer of the Belle II detector structure. The detector is designed to detect the KL mesons and muons above 600 MeV/c with high efficiency. The barrel shaped region around the intersection point covers a polar angular range of 45° to 125° while the forward and backward end caps extend this range to 20° to 155°. With the upgraded Geant4 model we observe the effectiveness of the new PhysicsList.https://ir.library.louisville.edu/uars/1020/thumbnail.jp

External perceptions of successful university brands

Branding in universities has become an increasingly topical issue, with some institutions committing substantial financial resources to branding activities. The particular characteristics of the sector present challenges for those seeking to build brands and it therefore seems to be timely and appropriate to investigate the common approaches of those institutions perceived as having successful brands. This study is exploratory in nature, seeking to investigate how successfully UK universities brand themselves, whether they are distinct and if the sector overall communicates effectively. This is approached through examining the perspective of opinion formers external to universities but closely involved with the sector – a key stakeholder group in UK higher education Overall, the research’s exploratory nature aims to further the debate on effective branding in UK higher education. The findings and conclusions identify some issues surrounding university branding activity; most UK universities were considered to be distinct from one another, but few were seen to have real fully formed brands. Although a number of institutions that were seen as having more ‘successful’ brands were identified, it was argued that whilst many UK universities communicate their brand well enough to key stakeholders, they fail to consistently do this across all audiences. It was also suggested that UK universities may concentrate on areas of perceived immediate strategic importance (in terms of branding) to an extent where others are neglected

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.

The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes. Weaver syndrome is a human overgrowth condition characterised by tall stature, dysmorphic facial features, learning disability and variable additional features. We performed exome sequencing in four individuals with Weaver syndrome, identifying a mutation in the histone methyltransferase, EZH2, in each case. Sequencing of EZH2 in additional individuals with overgrowth identified a further 15 mutations. The EZH2 mutation spectrum in Weaver syndrome shows considerable overlap with the inactivating somatic EZH2 mutations recently reported in myeloid malignancies. Our data establish EZH2 mutations as the cause of Weaver syndrome and provide further links between histone modifications and regulation of human growth

Exploring rationales for branding a university: Should we be seeking to measure branding in UK universities?

Although branding is now widespread among UK universities, the application of branding principles in the higher education sector is comparatively recent and may be controversial for internal audiences who question its suitability and efficiency. This paper seeks to investigate how and whether the effectiveness of branding activity in the higher education sector should be evaluated and measured, through exploratory interviews with those who often drive it; UK University marketing professionals. Conclusions suggest that university branding is inherently complex and therefore application of commercial approaches may be over simplistic. Whilst marketing professionals discuss challenges they do not necessarily have a consistent view of the objectives of branding activity although all were able to clearly articulate branding objectives for their university, including both qualitative and, to some extent, quantitative metrics. Some measures of the real value of branding activity are therefore suggested but a key debate is perhaps whether the objectives and role of branding in higher education needs to be clarified, and a more consistent view of appropriate metrics reached? Various challenges in implementing branding approaches are also highlighted

A low-density hot Jupiter in a near-aligned, 4.5-day orbit around a VV = 10.8, F5V star

We report the independent discovery and characterisation of a hot Jupiter in a 4.5-d, transiting orbit around the star TYC 7282-1298-1 ($V$ = 10.8, F5V). The planet has been pursued by the NGTS team as NGTS-2b and by ourselves as WASP-179b. We characterised the system using a combination of photometry from WASP-South and TRAPPIST-South, and spectra from CORALIE (around the orbit) and HARPS (through the transit). We find the planet's orbit to be nearly aligned with its star's spin. From a detection of the Rossiter-McLaughlin effect, we measure a projected stellar obliquity of $\lambda = -19 \pm 6^\circ$. From line-profile tomography of the same spectra, we measure $\lambda = -11 \pm 5^\circ$. We find the planet to have a low density ($M_{\rm P}$ = 0.67 $\pm$ 0.09 $M_{\rm Jup}$, $R_{\rm P}$ = 1.54 $\pm$ 0.06 $R_{\rm Jup}$), which, along with its moderately bright host star, makes it a good target for transmission spectroscopy. We find a lower stellar mass ($M_*$ = $1.30 \pm 0.07$ $M_\odot$) than reported by the NGTS team ($M_*$ = $1.64 \pm 0.21$ $M_\odot$), though the difference is only $1.5$ $\sigma$.Comment: Submitted to AJ. 9 pages, 6 figures, 5 table

WASP-189b: an ultra-hot Jupiter transiting the bright A star HR 5599 in a polar orbit

We report the discovery of WASP-189b: an ultra-hot Jupiter in a 2.72-d transiting orbit around the $V = 6.6$ A star WASP-189 (HR 5599). We detected periodic dimmings in the star's lightcurve, first with the WASP-South survey facility then with the TRAPPIST-South telescope. We confirmed that a planet is the cause of those dimmings via line-profile tomography and radial-velocity measurements using the HARPS and CORALIE spectrographs. Those reveal WASP-189b to be an ultra-hot Jupiter ($M_{\rm P}$ = 2.13 $\pm$ 0.28 $M_{\rm Jup}$; $R_{\rm P}$ = 1.374 $\pm$ 0.082 $R_{\rm Jup}$) in a polar orbit ($\lambda = 89.3 \pm 1.4^\circ$; $\Psi = 90.0 \pm 5.8^\circ$) around a rapidly rotating A6IV-V star ($T_{\rm eff}$ = 8000 $\pm$ 100 K; $v_* \sin i_*$ $\approx$ 100 km\, s$^{-1}$). We calculate a predicted equilibrium temperature of $T_{\rm eql}$ = 2641 $\pm$ 34 K, assuming zero albedo and efficient redistribution, which is the third hottest for the known exoplanets. WASP-189 is the brightest known host of a transiting hot Jupiter and the third-brightest known host of any transiting exoplanet. We note that of the eight hot-Jupiter systems with $T_{\rm eff}$ $>$ 7000 K, seven have strongly misaligned orbits, and two of the three systems with $T_{\rm eff}$ $\geq$ 8000 K have polar orbits (the third is aligned).Comment: Submitted to MNRAS. 10 pages, 9 figures, 3 table

Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells

Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro and in mouse models of serosal infection. In addition, the in vitro cytokine effects of the HSP70 isoform, Hsp72, on mesothelial cells were examined. Further, Hsp72 was measured in human pleural effusions and levels compared between non-infectious and infectious patients to determine the diagnostic accuracy of pleural fluid Hsp72 compared to traditional pleural fluid parameters. We showed that mesothelial release of Hsp72 was significantly raised when cells were treated with live and heat-killed Streptococcus pneumoniae. In mice, intraperitoneal injection of S. pneumoniae stimulated a 2-fold increase in Hsp72 levels in peritoneal lavage (p,0.01). Extracellular Hsp72 did not induce or inhibit mediator release from cultured mesothelial cells. Hsp72 levels were significantly higher in effusions of infectious origin compared to non-infectious effusions (p,0.05). The data establish that pleural mesothelial cells can release Hsp72 in response to bacterial infection and levels are raised in infectious pleural effusions. The biological role of HSP70 in pleural infection warrants exploration

Physical activity monitoring to assess disability progression in multiple sclerosis

Background: Clinical outcome measurement in multiple sclerosis (MS) usually requires a physical visit. Remote activity monitoring (RAM) using wearable technology provides a rational alternative, especially desirable when distance is involved or in a pandemic setting. Objective: To validate RAM in progressive MS using (1) traditional psychometric methods (2) brain atrophy. Methods: 56 people with progressive MS participated in a longitudinal study over 2.5 years. An arm-worn RAM device measured activity over six days, every six months, and incorporated triaxial accelerometry and transcutaneous physiological variable measurement. Five RAM variables were assessed: physical activity duration, step count, active energy expenditure, metabolic equivalents and a composite RAM score incorporating all four variables. Other assessments every six months included EDSS, MSFC, MSIS-29, Chalder Fatigue Scale and Beck’s Depression Inventory. Annualized brain atrophy was measured using SIENA. Results: RAM was tolerated well by people with MS; the device was worn 99.4% of the time. RAM had good convergent and divergent validity and was responsive, especially with respect to step count. Measurement of physical activity over one day was as responsive as six days. The composite RAM score positively correlated with brain volume loss. Conclusion: Remote activity monitoring is a valid and acceptable outcome measure in MS

A systematic review of biomarkers for disease progression in Parkinson's disease

Peer reviewedPublisher PD