Southcrest Cooperative Energy Feasibility Initiative

This research project provides an overview and feasibility analysis of a community-based project emerging in the Opportunity Zone of Southcrest, San Diego, California. Virgil Lorenzo (EdD), CEO of GLOBE Education Consultants, proposes a project inspired by the Mondragon Cooperative Corporation, aiming to introduce renewable energy to Southcrest. Lorenzo seeks Distributed Energy Resources (DER) Project Teams to kickstart the initiative, which involves outfitting homes with renewable energy sources like solar panels and micro wind turbines. Eventually, these homes will form a microgrid, potentially selling excess energy back to the main grid during peak usage. The project adopts a community-first approach, engaging Cristo Rey High School students and their families, while Shiley-Marcos School of Engineering students provide mentoring. To enhance sustainability and community involvement, we advocate restructuring the project to prioritize community input in decision-making processes

Opportunities for Sustainable Livelihoods in the Southwest Coast Lobster Fishery

Fish harvesters on the southwest coast of Newfoundland depend heavily on lobster to earn a living. In recent years, decreasing prices and other challenges have threatened the viability of the industry and the future employment of many harvesters’ families and others dependent on the small boat fishery. In the past few years southwest coast fishermen have had high average lobster catch rates per harvester and the number of active licenses in the region has been stable. Most of the lobster is sold to two local buyers and then exported, primarily to the United States. The Department of Fisheries and Oceans is the main regulator for harvesting, while the Department of Fisheries and Aquaculture regulates the industry post-harvest. Currently the environmental sustainability of the fishery is in question because although there are a number of conservation methods in place, exploitation rates are very high. Low prices contribute to the pressure on harvesters to fish intensively

Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2

OBJECTIVE: Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population. STUDY DESIGN: Retrospective. SETTING: Clinical data in the National COVID Cohort Collaborative database (N3C). METHODS: Deidentified patient data from the National COVID Cohort Collaborative database (N3C) were queried based on variant peak prevalence (untyped, alpha, delta, omicron 21K, and omicron 23A) from covariants.org to retrospectively analyze the incidence of vestibular disorders in patients with SARS-CoV-2 compared to control population, consisting of patients without documented evidence of COVID infection during the same period. RESULTS: Patients testing positive for COVID-19 were significantly more likely to have a vestibular disorder compared to the control population. Compared to control patients, the odds ratio of vestibular disorders was significantly elevated in patients with untyped (odds ratio [OR], 2.39; confidence intervals [CI], 2.29-2.50; CONCLUSIONS: The incidence of vestibular disorders differed between COVID-19 variants and was significantly elevated in COVID-19-positive patients compared to the control population. These findings have implications for patient counseling and further research is needed to discern the long-term effects of these findings

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy. Methods: We did an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with ischaemic stroke or transient ischaemic attack (TIA) within 48 h of onset. Participants were assigned in a 1:1 ratio using computer randomisation to receive loading doses and then 30 days of intensive antiplatelet therapy (combined aspirin 75 mg, clopidogrel 75 mg, and dipyridamole 200 mg twice daily) or guideline-based therapy (comprising either clopidogrel alone or combined aspirin and dipyridamole). Randomisation was stratified by country and index event, and minimised with prognostic baseline factors, medication use, time to randomisation, stroke-related factors, and thrombolysis. The ordinal primary outcome was the combined incidence and severity of any recurrent stroke (ischaemic or haemorrhagic; assessed using the modified Rankin Scale) or TIA within 90 days, as assessed by central telephone follow-up with masking to treatment assignment, and analysed by intention to treat. This trial is registered with the ISRCTN registry, number ISRCTN47823388. Findings: 3096 participants (1556 in the intensive antiplatelet therapy group, 1540 in the guideline antiplatelet therapy group) were recruited from 106 hospitals in four countries between April 7, 2009, and March 18, 2016. The trial was stopped early on the recommendation of the data monitoring committee. The incidence and severity of recurrent stroke or TIA did not differ between intensive and guideline therapy (93 [6%] participants vs 105 [7%]; adjusted common odds ratio [cOR] 0·90, 95% CI 0·67–1·20, p=0·47). By contrast, intensive antiplatelet therapy was associated with more, and more severe, bleeding (adjusted cOR 2·54, 95% CI 2·05–3·16, p<0·0001). Interpretation: Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice

Models of classroom assessment for course-based research experiences

Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and grading students engaged in this type of learning experience, the assessment aims and practices of a community of experienced course-based research instructors were collected and analyzed. This approach defines four aims of course-based research assessment—(1) Assessing Laboratory Work and Scientific Thinking; (2) Evaluating Mastery of Concepts, Quantitative Thinking and Skills; (3) Appraising Forms of Scientific Communication; and (4) Metacognition of Learning—along with a set of practices for each aim. These aims and practices of assessment were then integrated with previously developed models of course-based research instruction to reveal an assessment program in which instructors provide extensive feedback to support productive student engagement in research while grading those aspects of research that are necessary for the student to succeed. Assessment conducted in this way delicately balances the need to facilitate students’ ongoing research with the requirement of a final grade without undercutting the important aims of a CRE education

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy.Methods: We did an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with ischaemic stroke or transient ischaemic attack (TIA) within 48 h of onset. Participants were assigned in a 1:1 ratio using computer randomisation to receive loading doses and then 30 days of intensive antiplatelet therapy (combined aspirin 75 mg, clopidogrel 75 mg, and dipyridamole 200 mg twice daily) or guideline-based therapy (comprising either clopidogrel alone or combined aspirin and dipyridamole). Randomisation was stratified by country and index event, and minimised with prognostic baseline factors, medication use, time to randomisation, stroke-related factors, and thrombolysis. The ordinal primary outcome was the combined incidence and severity of any recurrent stroke (ischaemic or haemorrhagic; assessed using the modified Rankin Scale) or TIA within 90 days, as assessed by central telephone follow-up with masking to treatment assignment, and analysed by intention to treat. This trial is registered with the ISRCTN registry, number ISRCTN47823388.Findings: 3096 participants (1556 in the intensive antiplatelet therapy group, 1540 in the guideline antiplatelet therapy group) were recruited from 106 hospitals in four countries between April 7, 2009, and March 18, 2016. The trial was stopped early on the recommendation of the data monitoring committee. The incidence and severity of recurrent stroke or TIA did not differ between intensive and guideline therapy (93 [6%] participants vs 105 [7%]; adjusted common odds ratio [cOR] 0·90, 95% CI 0·67–1·20, p=0·47). By contrast, intensive antiplatelet therapy was associated with more, and more severe, bleeding (adjusted cOR 2·54, 95% CI 2·05–3·16,

Fostering Sustainable Food Systems in Newfoundland: A Case Study of the West Coast Farmers’ Market

This study attempted to assess the potential for a farmers’ market on the west coast of Newfoundland and Labrador, using the West Coast Farmers’ Market as a case study. An evaluation of this market was conducted from July 2011 – March 2012 to explore its challenges and success, and to seek potential ways forward for this specific market as well as for others in the province. In order to assess the potential of a farmers’ market we committed to the following objectives: 1. To assess the supply and demand of locally produced food in western Newfoundland 2. To gather and analyze stakeholder views on the need and potential for developing farmers' markets in this region, as well as the barriers to its development 3. To examine farmers' market governance models in other jurisdictions 4. To evaluate current efforts to develop a farmers' market in reference to the case site of Corner Brook and to make practical recommendations for continued development at this site and in other communities in the province. This research project is part of a larger study of food security in the Humber River Basin which examined the strengths and weaknesses of the local food system in the Humber River Basin through a community food security assessment

All Party Green Agenda Newfoundland & Labrador 2011 Provincial Election

Newfoundland and Labrador possesses a wealth of natural and environmental resources. This includes important wildlife habitat, forest, freshwater and marine ecosystems. With such wealth comes a duty to protect and enhance the natural environment. The 2011 provincial election is a watershed election for the province. After several years of prosperity which has seen significant revenues from non-renewable offshore resources invested to modernize public infrastructure such as hospitals, roads and schools among other things, the opportunity exists for the next government to chart an environmentally friendly and sustainable future for all Newfoundlanders and Labradorians. This bold innovative environmental future is to focus on: • embracing alternative energy resources; • protecting our peatlands resources; • investing in leading edge waste management practices; • reducing the environmental impacts of the oil industry; • moving to less carbon intensive practices; • repositioning the forestry sector to recognize its diversity and to ensure its environmental sustainability; and, • working to create a food production system that is less dependent on imports. It is to these issues that this environmental brief seeks commitment from all political parties in the 2011 provincial election

Edward Elgar and the First World War: An Exploration of the Reception History of His Wartime Music

Edward Elgar offers an interesting case study in the British cultural response to the First World War. By the time of the conflict, Elgar’s reputation as an important national figure was firmly established; as such, his music became part of the official ‘war effort’. Despite this, many of his wartime compositions have failed to obtain a permanent place in the concert repertoire, with this music often seen as necessary for the time but insignificant in comparison to the rest of his output. This thesis explores Elgar’s creative response to the war and evaluates the importance of his wartime music to his overall compositional development, particularly through consideration of the reception history of his wartime works. Elgar’s compositions demonstrate the changing responses of music to the war, from his first patriotic statements to the introspective musical works of the postwar years. Indeed, these works offer an insight into the range of emotions war engendered and the role of the arts in expressing them. In this thesis, specific consideration is given to The Spirit of England, op. 80 (1915–17) and The Fringes of the Fleet (1917) through musical analysis and a critique of their reception history. Exploring the reception of Elgar’s music not only enables a greater understanding of the significance and meaning of these individual pieces, but also allows one to gain a sense of the broader musical discourse at the time, thus bringing Elgar into dialogue with more recent scholarship in twentieth-century British music culture