Synthesis and different biological activities of novel benzoxazoles

A series of 2-[4-(4-substitutedbenzamido/phenylacetamido/butanamido)phenyl]-5-ethylsulphonyl-benzoxazole derivatives were synthesized and biologically evaluated as possible antimicrobial agents and inhibitors of tyrosinase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 128-16 μg/ml against some Gram-positive, Gram-negative bacteria as well as Candida albicans and C. krusei. The compound 10 displayed higher activity in this series against methicilline resistant Staphylococcus aureus (MRSA) with a MIC value of 16 μg/ml than the compared control drugs ampicillin and ceftriaxone. Compound 14 showed moderate tyrosinase inhibition, however, none of the compounds showed effect as inhibitor of AChE and BChE

A study on the antioxidant activities of some new benzazole derivatives

The in vitro antioxidant properties of some new benzazole derivatives ( 1–10 ) such as benzoxazoles, ben- zimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH- dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2- diphenyl-1-picrylhydrazyl (DPPH). Compounds 1 , 2 , 4 and 6 , showed potent scavenging effect on super- oxide radical at 10 –3 M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10 –3 M concentration