Urologic Cancer Molecular Biology

An adequate understanding of the molecular mechanisms of the most common urological cancers is necessary for a correct approach to diagnosis, precise treatment, but also for the follow-up of these patients. It is necessary to understand the molecular mechanisms underlying the carcinogenic processes, the molecular pathways involved in this process, and also to describe the biomarkers useful for diagnosis but also for predictability, treatment, and natural history. In addition, it would be useful to describe a list of useful molecules currently under investigation as possible biomarkers to improve the income of cancer patients

EFFICIENCY OF DISINFECTION AND STERILIZATION IN DENTAL MEDICINE PRACTICE. REVIEW.

Medical devices that come into contact with sterile tissues or body fluids are considered critical items. In dentistry, conventional manual decontamination of medical device surfaces is used, and this requires a two-step procedure that includes rehydration of the surface followed by decontamination, for effective inactivation of bacteria and viruses on dry surfaces The most effective decontamination agents are ethanol in high concentration while sodium hypochlorite and hydrogen peroxide require a minimum concentration to be effective with little impact on human health. The bactericidal action of quaternaries has been attributed to inactivation of energy-producing enzymes, denaturation of essential cellular proteins, and disruption of the cell membrane. Sterilization destroys all microorganisms on the surface of an item or in a fluid to prevent the transmission of diseases associated with the use of that item Most medical and surgical devices used in medical facilities are made of materials that are heat stable and therefore undergo high temperature sterilization, primarily with steam

PERIODONTAL DISEASE AND COMPLICATIONS IN THE CONTEXT OF THE COVID-19 PANDEMIC. INACTIVATION OF PATHOGENS AT THE LEVEL OF A DENTAL OFFICE IN THE CONTEXT OF THE PANDEMIC. REVIEW.

When a disease is new to humans, only very few people are immune to it. In such cases, there is no vaccine and the result can be a rapid increase in the incidence of the disease. How dangerous or deadly that disease is – it all depends on the specific virus in question and the general state of health of each individual patient. If a disease does not only spread regionally but ends up affecting entire countries and continents, then experts speak of a pandemic. Periodontal disease is a bacterial infection that causes inflammation of the supporting tissues of the tooth. Experts say that there is a dangerous link between this and the COVID-19 infection, which leads to hospitalization or even admission to intensive care, periodontal disease can lead to complications of Covid-19. The association between coronavirus disease 2019 infection and periodontitis has also been investigated in the retrospective studies. In the current context we have solutions to eradicate already known pathogens, but new pathogens or changes to existing ones occur that require time and research to find a solution

Periorbital Facial Necrotizing Fasciitis in Adults: A Rare Severe Disease with Complex Diagnosis and Surgical Treatment—A New Case Report and Systematic Review

(1) Background: Necrotizing fasciitis (NF) is a severe and aggressive pathology with a rapid progression and high mortality risk. Periocular NF is a rare condition associated with a lower mortality risk but significantly higher disabling sequelae. (2) Methods: We present the case of a 67-year-old homeless patient, a victim of assault, with multiple untreated comorbidities (diabetes mellitus, cardiac conditions, and schizophrenia) and a delayed diagnosis of periocular necrotizing fasciitis. The condition showed a cyclical evolution influenced by the existing comorbidities, and the patient underwent both surgical and medical treatment with a multidisciplinary team. Additionally, we report a systematic review of cases from the literature. (3) Results: The patient’s survival outcomes were favorable; however, the sequelae were disabling, not only concerning aesthetic aspects but also due to the loss of the affected eye globe. The systematic review revealed the rarity of such cases and the peculiarities of the presented case compared to those reported in the literature up to this point. (4) Conclusions: Understanding the signs, symptoms, and predisposing factors, as well as the potential rare localizations of NF, including the periocular region, can lead to the early diagnosis and treatment with good functional and aesthetic outcomes, minimizing significant disabilities

Corelattions Between CD31, CD68, MMP-2 and MMP-9 Expression in Allograft Cardiac Rejection – Immunohistochemical Study

Introduction. The cardiac allograft rejections from the post-transplant period are attributable to the acute cellular rejection monitored by multiple endomyocardial biopsies. Compared to this, humoral rejection remains a matter of debate, with multiple therapeutic strategies, poor prognosis, and persisting uncertainty about diagnostic criteria. Acute allograft rejection is associated with significant modifications of the extracellular matrix compartment mainly regulated by matrix metalloproteinases (MMPs). In this context, the aim of this study was to evaluate the expression of MMP-2 and -9 and CD31, CD68 (endothelial and histiocytic markers) and the correlations between them using immunohistochemistry, in patients with cardiac allografts

Assessment of Basal Cell Carcinoma Using Dermoscopy and High Frequency Ultrasound Examination

Basal cell carcinoma (BCC) is the most common form of cutaneous neoplasia in humans, and dermoscopy may provide valuable information for histopathological classification of BCC, which allows for the choice of non-invasive topical or surgical therapy. Similarly, dermoscopy may allow for the identification of incipient forms of BCC that cannot be detected in clinical examination. The importance of early diagnosis using the dermoscopy of superficial BCC forms is proven by the fact that despite their indolent clinical appearance, they can be included in high-risk BCC forms due to the rate of postoperative recurrence. Nodular pigmentary forms of BCCs present ovoid gray-blue nests or multiple gray-blue dots/globules associated with arborized vessels, sometimes undetectable on clinical examination. The management of BCC depends on this, as pigmentary forms have been shown to have a poor response to photodynamic therapy. High frequency ultrasound examination (HFUS) aids in the diagnosis of BCC with hypoechoic tumour masses, as well as in estimating tumour size (thickness and diameter), presurgical margin delineation, and surgical planning. The examination is also useful for determining the invasion of adjacent structures and for studying local recurrences. The use of dermoscopy in combination with HFUS allows for optimisation of the management of the oncological patient