Thrombus aspiration in patients with ST-elevation myocardial infarction: results of a national registry of interventional cardiology.

BACKGROUND: We aimed to evaluate the impact of thrombus aspiration (TA) during primary percutaneous coronary intervention (P-PCI) in 'real-world' settings. METHODS: We performed a retrospective study, using data from the National Registry of Interventional Cardiology (RNCI 2006-2012, Portugal) with ST-elevation myocardial infarction (STEMI) patients treated with P-PCI. The primary outcome, in-hospital mortality, was analysed through adjusted odds ratio (aOR) and 95% confidence intervals (95%CI). RESULTS: We assessed data for 9458 STEMI patients that undergone P-PCI (35% treated with TA). The risk of in-hospital mortality with TA (aOR 0.93, 95%CI:0.54-1.60) was not significantly decreased. After matching patients through the propensity score, TA reduced significantly the risk of in-hospital mortality (OR 0.58, 95%CI:0.35-0.98; 3500 patients). CONCLUSIONS: The whole cohort data does not support the routine use of TA in P-PCI, but the results of the propensity-score matched cohort suggests that the use of selective TA may improve the short-term risks of STEMI.info:eu-repo/semantics/publishedVersio

Appraising Cross-National Income Inequality Databases: An Introduction

In response to a growing interest in comparing inequality levels and trends across countries, a number of cross-national inequality databases are now available. These databases differ considerably in purpose, coverage, data sources, inclusion and exclusion criteria, and quality of documentation. A special issue of the Journal of Economic Inequality, which this paper introduces, is devoted to an assessment of the merits and shortcomings of eight such databases. Five of these sets are microdata-based: CEPALSTAT, Income Distribution Database (IDD), LIS, PovcalNet, and Socio-Economic Database for Latin America and the Caribbean (SEDLAC). Two are based on secondary sources: "All the Ginis" (ATG) and the World Income Inequality Database (WIID); and one is generated entirely through multiple-imputation methods: the Standardized World Income Inequality Database (SWIID). Although there is much agreement across these databases, there is also a non-trivial share of country/year cells for which substantial discrepancies exist. In some cases, different databases would lead users to radically different conclusions about inequality dynamics in certain countries and periods. The methodological differences that lead to these discrepancies often appear to be driven by a fundamental trade-off between a wish for broader coverage on the one hand, and for greater comparability on the other. These differences across databases place considerable responsibility on both producers and users: on the former, to better document and explain their assumptions and procedures, and on the latter, to understand the data they are using, rather than merely taking them as true because available

Fracturas dos ossos longos “um projecto para o futuro”

Os autores dividem as fracturas dos ossos longos em níveis; classificam as fracturas dos diferentes níveis; traçam normas de conduta terapêutica para cada fractura, e propõem um método de classificação dos resultados com base em parâmetros que avaliam todo um membro, e não apenas o aspecto radiológico da fractura. Pretendem, desta forma, uniformizar a classificação das fracturas e dos resultados, de modo a tornar possível a computorização das histórias clínicas

Produtividade do arroz de terras altas influenciada por plantas de cobertura e manejo do solo.

Com o objetivo de avaliar o efeito da utilização de diferentes adubos verdes, plantados no sistema plantio direto (SPD) e convencional (SPC) na produtividade da cultura do arroz, foi conduzido um ensaio, na Fazenda Capivara, Embrapa Arroz e Feijão, no qual foram utilizadas como plantas de cobertura do solo as seguintes culturas: Crotalária (Crotalaria juncea), Feijão Guandú (Cajanus cajan), Mucuna preta (Mucuna aterrima), Sorgo (Sorghum bicolor) e plantas espontâneas e a cultivar de arroz BRS Pepita

Exploring the Microbiome of Healthy and Diseased Peri-Implant Sites Using Illumina Sequencing

Aim To compare the microbiome of healthy (H) and diseased (P) peri-implant sites and determine the core peri-implant microbiome. Materials and Methods Submucosal biofilms from 32 H and 35 P sites were analyzed using 16S rRNA sequencing (MiSeq, Illumina), QIIME and HOMINGS. Differences between groups were determined using Principal Coordinate Analysis (PCoA), t-tests and Wilcoxon rank sum test and FDR-adjusted. The peri-implant core microbiome was determined. Results PCoA showed partitioning between H and P at all taxonomic levels. Bacteroidetes, Spirochetes and Synergistetes were higher in P, while Actinobacteria prevailed in H (p\u3c0.05). Porphyromonas and Treponema were more abundant in P and while Rothia and Neisseria were higher in H (p\u3c0.05). The core peri-implant microbiome contained Fusobacterium, Parvimonas and Campylobacter sp. T. denticola and P. gingivalis levels were higher in P, as well as F. alocis, F fastidiosum and T. maltophilum (p\u3c0.05). Conclusion The peri-implantitis microbiome is commensal-depleted and pathogen-enriched, harboring traditional and new pathogens. The core peri-implant microbiome harbors taxa from genera often associated with periodontal inflammation

Extraction of antioxidant compounds from enzymatic hydrolysis of brewer's spent grain after solid-state fermentation

Phenolic compounds have antioxidant properties that can benefit human health and food preservation. During solid-state fermentation (SSF) of lignocellulosic substrates, filamentous fungi produce carbohydrate degrading enzymes which can amplify the quantity of phenolics released linked to vegetable matrix when applying enzymatic hydrolysis (EH). In this work, brewer's spent grain (BSG) was fermented with Aspergillus ibericus and later the lignocellulolytic enzymes were extracted and used on an EH of fermented BSG. EH was optimized by a Box-Behnken design approach, studying the effect of three factors in the extraction of antioxidant compounds, namely the quantity of SSF-crude extract added, load of fermented solid and addition of -glucosidase. The maximum increase of phenols and antioxidant activity in comparison to unhydrolyzed BSG were 42.9 mg/g and 83.5 mol trolox/g, respectively. -glucosidase addition and low solid-load had a positive effect on the phenols released and antioxidant activity. The quantities of crude SSF-extract studied did not had a significant effect on phenols and antioxidant released.Helena Fernandes was supported by PhD grant (SFRH/BD/131219/2017). Funded by the European Regional Development Fund (ERDF) under the Project SPO3 (ref.: POCI-01-0145-FEDER030377) BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the ERDF under the scope of Norte2020-Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersio

Solid-state fermentation of winery and olive mill wastes for lignocellulolytic enzymes and antioxidant compounds production

Solid-state fermentation (SSF) is a process that can use agroin-dustry solid residues as substrate for microbial growth. During SSF, value-added products and fermented biomass are generated con-tributing for the reutilization of otherwise pollutant agroindustry wastes. By SSF, fungi can hydrolyze anti-nutritional factors of plant-based residues, as the lignocellulosic matrix, and produce enzymes, phenolic compounds and other bioactive compounds, making this a high interest bioprocess for the aquafeed industry. The present study optimized (simplex centroid design) the mixture of winery and olive mill wastes to produce lignocellulolytic enzymes and to extract phenolic compounds through SSF by Aspergillus niger. The substrate mixture that maximized the production of lignocellu-lolytic enzymes, antioxidant and phenolic compounds was 0.44 g exhausted olive pomace/gds; 0.3 g exhausted grape marc/gds; 0.15 g vine-shoot trimmings and 0.1 g crude olive pomace/gds. The crude extract will be applied as additive in meagre (Argyrosomus regius) diets, to improve the feed utilization efciency of low-sh meal-based diets, contributing to the sustainability of aquafeeds.Funded by Programa Operacional Mar2020, Portugal 2020 under the project InovFeed (ref.MAR-02.01.01-FEAMP-0111) and BioTec Norte operation (NORTE-01-0145-FEDER-000004) funded by ERDF under the scope of Norte 2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersio

Privacy threat analysis of mobile social network data publishing

With mobile phones becoming integral part of modern life, the popularity of mobile social networking has tremendously increased over the past few years, bringing with it many benefits but also new trepidations. In particular, privacy issues in mobile social networking has recently become a significant concern. In this paper we present our study on the privacy vulnerability of the mobile social network data publication with emphases on a re-identification and disclosure attacks. We present a new technique for uniquely identifying a targeted individual in the anonymized social network graph and empirically demonstrate the capability of the proposed approach using a very large social network datasets. The results show that the proposed approach can uniquely re-identify a target on anonymized social network data with high success rate