Susceptibility of Multi-Drug-Resistant Organisms (MDROs), Isolated from Cases of Urinary Tract Infection to Fosfomycin (The New Antibiotic) vis-a-vis Other Antimicrobial Agents

Introduction: Urinary tract infection (UTI) is one of the commonest infections encountered in the hospital. Most of the hospital UTIs are caused by MDROs. There is scarcity of available drugs to treat MDR infections. In this scenario, reevaluation of the old antimicrobial agents is being done. Fosfomycin is one such old molecule. The studies suggest that Fosfomycin may provide a useful option for the treatment of patients with the MDR/XDR difficult-to-treat infections.Materials and Methods: Urine samples (including catheter samples) were collected in sterile containers; cultured on CHROME agar, using calibrated loop; colony count was done in positive cultures; identification and antimicrobial susceptibility of the organism was done by VITEK2 compact system. Susceptibility pattern of antimicrobial agents used for treatment of UTI including Fosfomycin was analyzed.Results: Of the 502 urinary MDRO isolates, 74.9% were ESBLs and 29.49% were CROs. MDRO susceptibility was 88% to Fosfomycin, 70.52% to Ertapenem, 53.98% to Nitrofurantoin, 37.05% to Trimethoprim-Sulfamethoxazole, 22.31% to Norfloxacin, 20.91% to Ciprofloxacin, and 10.96% to Ampicillin respectively.Discussion: Gupta et al.10 reported 52.6% E. coli urinary isolates to be ESBLs and all were susceptible to Fosfomycin. In the present study, 76.8% Escherichia coli isolates were ESBLs and 98.5% only were susceptible to Fosfomycin