4,496 research outputs found
Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients
Electro-cortical activity in patients with epilepsy may show abnormal
rhythmic transients in response to stimulation. Even when using the same
stimulation parameters in the same patient, wide variability in the duration of
transient response has been reported. These transients have long been
considered important for the mapping of the excitability levels in the
epileptic brain but their dynamic mechanism is still not well understood.
To understand the occurrence of abnormal transients dynamically, we use a
thalamo-cortical neural population model of epileptic spike-wave activity and
study the interaction between slow and fast subsystems.
In a reduced version of the thalamo-cortical model, slow wave oscillations
arise from a fold of cycles (FoC) bifurcation. This marks the onset of a region
of bistability between a high amplitude oscillatory rhythm and the background
state. In vicinity of the bistability in parameter space, the model has
excitable dynamics, showing prolonged rhythmic transients in response to
suprathreshold pulse stimulation. We analyse the state space geometry of the
bistable and excitable states, and find that the rhythmic transient arises when
the impending FoC bifurcation deforms the state space and creates an area of
locally reduced attraction to the fixed point. This area essentially allows
trajectories to dwell there before escaping to the stable steady state, thus
creating rhythmic transients. In the full thalamo-cortical model, we find a
similar FoC bifurcation structure.
Based on the analysis, we propose an explanation of why stimulation induced
epileptiform activity may vary between trials, and predict how the variability
could be related to ongoing oscillatory background activity.Comment: http://journal.frontiersin.org/article/10.3389/fncom.2017.00025/ful
Recommended from our members
Adapting the International System of Units to the twenty-first century
We review the proposal of the International Committee for Weights and Measures
(Comité International des Poids et Mesures, CIPM), currently being considered by
the General Conference on Weights and Measures (Conférences Générales des Poids et
Mesures, CGPM), to revise the International System of Units (Le Système International
d’Unitès, SI). The proposal includes new definitions for four of the seven base units of
the SI, and a new form of words to present the definitions of all the units. The objective
of the proposed changes is to adopt definitions referenced to constants of nature, taken
in the widest sense, so that the definitions may be based on what are believed to be
true invariants. In particular, whereas in the current SI the kilogram, ampere, kelvin and
mole are linked to exact numerical values of the mass of the international prototype of the
kilogram, the magnetic constant (permeability of vacuum), the triple-point temperature
of water and the molar mass of carbon-12, respectively, in the new SI these units are linked
to exact numerical values of the Planck constant, the elementary charge, the Boltzmann
constant and the Avogadro constant, respectively. The new wording used expresses the
definitions in a simple and unambiguous manner without the need for the distinction
between base and derived units. The importance of relations among the fundamental
constants to the definitions, and the importance of establishing a mise en pratique for
the realization of each definition, are also discussed
Living in the Seventies
An Australian teenager living in Jakarta in the 1970s meets an Iraqi diplomat and is attracted by the exotic
Should radioiodine now be first line treatment for Graves' disease?
Background
Radioiodine represents a cost-effective treatment option for Graves’ disease. In the UK, it is traditionally reserved for patients who relapse after initial thionamide therapy. In a change from current practice, the new guidelines of the National Institute for Health and Care Excellence (NICE) recommends that radioiodine should now be first line therapy for Graves’ disease. However, the safety of radioiodine with respect to long-term mortality risk has been the subject of recent debate. This analysis examines evidence from treatment related mortality studies in hyperthyroidism and discusses their implications for future Graves’ disease treatment strategies.
Main body
Some studies have suggested an excess mortality in radioiodine treated cohorts compared to the background population. In particular, a recent observational study reported a modest increase in cancer-related mortality in hyperthyroid patients exposed to radioiodine. The interpretation of these studies is however constrained by study designs that lacked thionamide control groups or information on thyroid status and so could not distinguish the effect of treatment from disease. Two studies have shown survival advantages of radioiodine over thionamide therapy, but these benefits were only seen when radioiodine was successful in controlling hyperthyroidism. Notably, increased mortality was associated with uncontrolled hyperthyroidism irrespective of therapy modality.
Conclusions
Early radioiodine treatment will potentially reduce mortality and should be offered to patients with severe disease. However, thionamides are still suitable for patients with milder disease, contraindications to radioiodine, or individuals who choose to avoid permanent hypothyroidism. Ultimately, a patient individualised approach that prioritises early and sustained control of hyperthyroidism will improve long-term outcomes regardless of the therapy modality used
- …