‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬ ‫ـ‬

Abstract Aim of the study To find out the relation between tumour necrosis factor alpha (TNF-α), immunoglobulin-E and antioxidant levels in the patients with mild or moderate/severe cases. Ninety subject (male , female) were enrolled in this study .Fifty patients with AR were subdivided into two groups i.e. mild (comprising 20 patients) with allergic rhinitis, moderate/ severe (comprising 30 patients) with allergic rhinitis. Forty subjects who are apparently healthy were taken as a control group. Serum TNF-α and IgE were determind by using enzyme-linked immunosorbent assay (ELISA). Malondialdehyde (MDA)levels and catalase activity were determined by using colorimetric method. Serum levels of TNF-α was significantly higher in mild and moderate/severe groups compared with control group (p<0.01). IgE and MDA were significantly higher in mild group ( p< 0.05) and in moderate/severe group(p< 0.01). Catalase was significantly decreased in mild and moderate/severe groups compared with control group (p<0.05) (p<0.01) respectively .A significant positive correlation between TNF-α , IgE and MDA in AR patients in mild and moderate/severe cases. A significant negative correlation between TNF-α ,IgE and catalase in AR patients in mild and moderate/severe cases. Oxidative stress stimulate the production of TNF-α and IgE in patients of AR. ‫الخالصة