Charged exciton emission at 1.3 μ\mum from single InAs quantum dots grown by metalorganic chemical vapor deposition

We have studied the emission properties of self-organized InAs quantum dots (QDs) grown in an InGaAs quantum well by metalorganic chemical vapor deposition. Low-temperature photoluminescence spectroscopy shows emission from single QDs around 1300 nm; we clearly observe the formation of neutral and charged exciton and biexciton states, and we obtain a biexciton binding energy of 3.1 meV. The dots exhibit an s-p shell splitting of approximately 100 meV, indicating strong confinement.Comment: 3 pages, 3 figures, submitted AP

R&D Status of Nuclear Emulsion For Directional Dark Matter Search

In this study, we are doing R&D for directional dark matter search with nuclear emulsion. First of all, higher resolution nuclear emulsion with fine silver halide crystals was developed in the production facility of emulsion at Nagoya university, and we confirmed that it can detect the expected nuclear recoil tracks. The readout of submicron tracks was required the new technology. We developed the expansion technique, and could readout the signal by shape analysis with optical microscopy. The two dimensional angular resolution is 36 degrees at the original track length of range from 150nm to 200nm with optical microscopy. Finally we demonstrated by using recoiled nuclei induced by 14.8MeV neutron, and confirmed the technique.Moreover, we developed the X-ray microscope system with SPring-8 as final check with higher resolution of selected candidate tracks with optical microscopy. The angular resolution was improved from 31 degrees with optical microscopy to 17degrees with X-ray microscopy at the track length of range from 150nm to 250nm. We are developing the practical system and planning for start of the test running with prototype detector.Comment: Proceedings of the 3rd International conference on Directional Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 201

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies

Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate, lung, and renal carcinomas, melanoma, neuroblastoma, and multiple myeloma. Accumulating evidence suggests that the inflammatory cytokine interleukin (IL)-6 is frequently upregulated and is implicated in the ability of cancer cells to metastasize to bone. IL-6 is able to activate various cell signaling cascades that include the STAT (signal transducer and activator of transcription) pathway, the PI3K (phosphatidylinositol-3 kinase) pathway, and the MAPK (mitogen-activated protein kinase) pathway. Activation of these pathways may explain the ability of IL-6 to mediate various aspects of normal and pathogenic bone remodeling, inflammation, cell survival, proliferation, and pro-tumorigenic effects. This review article will discuss the role of IL-6: 1) in bone metabolism, 2) in cancer metastasis to bone, 3) in cancer prognosis, and 4) as potential therapies for metastatic bone cancer