Form and Geometry in Decorative Tile Work in Khayyatha Mosque, Isfahan

Decoration has always had a pivotal role in Persian architecture. Since long time ago, for example, tile work has had a special place for most architects around the world especially Persian architects. Close examination of Persian tile work, in terms of form and geometric features, reveals the architects' mastery over this art, geometry as well as mathematics. The analyses of tile decorations and fretworks, formally and geometrically, may indicate that how the tile work accomplished structurally. One of the famous mosques in Isfahan enjoying a rich variety of tile work is Khayyatha Mosque. Examination of forms used in tile work in of the mosque revealed the geometric structures and proportions, the workforce needed and the number of tiles applied in each inscription based on specific colors. So far, little study has been carried on tile fretwork in terms of form. The present study examined, for the first time, the tile fretwork in Khayyatha Mosque. After introducing the mosque, the tile fretwork used in the mosque was studied and the patterns were analyzed mathematically. The methodology was mainly based on quantitative analyses using mathematical calculations as well as geometric drawings. The result indicated that the nature of form and geometric proportions of tile work has had a direct impact on the workforce needed and on the kinds of tiles applied. Also, the most frequently used tile works, in terms of form and pattern, were identified

Form and Geometry in Decorative Tile Work in Khayyatha Mosque, Isfahan

Decoration has always had a pivotal role in Persian architecture. Since long time ago, for example, tile work has had a special place for most architects around the world especially Persian architects. Close examination of Persian tile work, in terms of form and geometric features, reveals the architects' mastery over this art, geometry as well as mathematics. The analyses of tile decorations and fretworks, formally and geometrically, may indicate that how the tile work accomplished structurally. One of the famous mosques in Isfahan enjoying a rich variety of tile work is Khayyatha Mosque. Examination of forms used in tile work in of the mosque revealed the geometric structures and proportions, the workforce needed and the number of tiles applied in each inscription based on specific colors. So far, little study has been carried on tile fretwork in terms of form. The present study examined, for the first time, the tile fretwork in Khayyatha Mosque. After introducing the mosque, the tile fretwork used in the mosque was studied and the patterns were analyzed mathematically. The methodology was mainly based on quantitative analyses using mathematical calculations as well as geometric drawings. The result indicated that the nature of form and geometric proportions of tile work has had a direct impact on the workforce needed and on the kinds of tiles applied. Also, the most frequently used tile works, in terms of form and pattern, were identified

Form and Geometry in Decorative Tile Work in Khayyatha Mosque, Isfahan

Decoration has always had a pivotal role in Persian architecture. Since long time ago, for example, tile work has had a special place for most architects around the world especially Persian architects. Close examination of Persian tile work, in terms of form and geometric features, reveals the architects' mastery over this art, geometry as well as mathematics. The analyses of tile decorations and fretworks, formally and geometrically, may indicate that how the tile work accomplished structurally. One of the famous mosques in Isfahan enjoying a rich variety of tile work is Khayyatha Mosque. Examination of forms used in tile work in of the mosque revealed the geometric structures and proportions, the workforce needed and the number of tiles applied in each inscription based on specific colors. So far, little study has been carried on tile fretwork in terms of form. The present study examined, for the first time, the tile fretwork in Khayyatha Mosque. After introducing the mosque, the tile fretwork used in the mosque was studied and the patterns were analyzed mathematically. The methodology was mainly based on quantitative analyses using mathematical calculations as well as geometric drawings. The result indicated that the nature of form and geometric proportions of tile work has had a direct impact on the workforce needed and on the kinds of tiles applied. Also, the most frequently used tile works, in terms of form and pattern, were identified

Effect of sono-guided fascia iliaca block versus spinal anesthesia on tourniquet pain during foot and ankle orthopedic surgery

Introduction: The pneumatic thigh tourniquets are routinely used in below knee orthopedic surgeries to provide a bloodless operative field. Moderate to severe thigh pain following tourniquet inflation is a common patient complaint that can be so severe that necessitate general anesthesia. In the present study, we assessed the effectiveness of a single dose fascia iliaca block on thigh tourniquet pain during unilateral orthopedic foot and ankle surgery performed under popliteal sciatic nerve block. Materials and Methods: Seventy-two American Society of Anesthesiologists physical status 1 or 2 patients were randomly divided into two equal groups of spinal anesthesia and fascia iliaca block. Spinal anesthesia was provided with 15 mg of 0.5% hyperbaric bupivacaine. Fascia iliaca and popliteal blocks were performed under the guidance of ultrasound using 30 ml of 1.5% lidocaine and 20 ml of lidocaine 1.5% with epinephrine 1:200000, respectively. Results: Intraoperative tourniquet pain and the use of analgesics were significantly higher and patient satisfaction was significantly lower in the fascia iliaca block group than in the spinal anesthesia group. Conclusion: Fascia iliaca block alone was inadequate for relieving thigh tourniquet pain during surgery. However, for patients who are not suitable for spinal or general anesthesia, it can be used with supplementary intravenous analgesia for tolerance of thigh tourniquet in foot and ankle surgeries performing under popliteal sciatic nerve block

Genetic Diversity of Toxoplasma gondii by Serological and Molecular Analyzes in Different Sheep and Goat Tissues in Northeastern Iran

Background: Toxoplasmosis is a parasitic disease caused by compilation protozoan agent  Toxoplasma gondii, leading to significant financial and quality-adjusted life-year losses. Overcooked or raw meat consumption has been a considerable transmission route. The present study was conducted to determine the seropositivity rate of T. gondii in sheep and goats by serological and molecular tests and genotyping of obtained isolates in northeast Iran. Methods: Blood and tissue samples (diaphragm, heart) of 296 animals (including 168 sheep and 128 goats) were collected from the slaughterhouse in Quchan Country from august 2016 to April 2017. Modified agglutination test (MAT) and the PCR method performed to detect parasite DNA on tissues.PCR-RFLP method of GRA6 gene was used to determine the genotype of T. gondii. In addition, sequencing analysis was performed to evaluate the Toxoplasma type strains. Results: Serum positive for MAT results were found in 27.4% of sheep and 23.4% of goats. Positive PCR of B1 gene results in diaphragm and heart tissues of sheep and goats was 47.8% and 26.1%, 40% and 23.3%, respectively. PCR of GRA6 gene results were positive in 10 samples that RFLP technique results using MseІ enzyme revealed genotype І. Sequencing and phylogenetic analysis revealed DNA of all samples was closely related to Toxoplasma type І. Conclusion: Concerning the high seropositivity rate of toxoplasmosis, undertaking an appropriate preventive program for reducing the prevalence of T. gondii infection by raw or undercooked meat consumption of livestock is recommended. Our study supports the notion that these animals' consumption of raw and undercooked meat can be a probable source of human toxoplasmosis

Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis

Atopic Dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin in which no monogenic cause has been identified so far. Meanwhile Filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of FLG gene.Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of the FLG gene. The frequencies of allele A in variants of rs3126065, rs2786680, and rs1933063 as well as allele C in variant rs3814300 were 100%. There was no significant difference between allele frequencies in variants rs2485518 and rs3814299. The only genotypes in variants of rs3814299 and rs2485518 were GG and CC, respectively, with no significant difference between the patients and controls. This study demonstrated that there was no significant association between polymorphisms of FLG gene variants and AD.</p

Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial

ObjectiveSpirulina (arthrospira platensis) is a cyanobacterium proven to have anti-inflammatory, antiviral, and antioxidant effects. However, the effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19 is currently unclear. This study aimed to evaluate the efficacy and safety of high-dose Spirulina platensis for SARS-CoV-2 infection.Study DesignWe conducted a randomized, controlled, open-label trial involving 189 patients with COVID-19 who were randomly assigned in a 1:1 ratio to an experimental group that received 15.2g of Spirulina supplement plus standard treatment (44 non-intensive care unit (non-ICU) and 47 ICU), or to a control group that received standard treatment alone (46 non-ICU and 52 ICU). The study was conducted over six days. Immune mediators were monitored on days 1, 3, 5, and 7. The primary outcome of this study was mortality or hospital discharge within seven days, while the overall discharge or mortality was considered the secondary outcome.ResultsWithin seven days, there were no deaths in the Spirulina group, while 15 deaths (15.3%) occurred in the control group. Moreover, within seven days, there was a greater number of patients discharged in the Spirulina group (97.7%) in non-ICU compared to the control group (39.1%) (HR, 6.52; 95% CI, 3.50 to 12.17). Overall mortality was higher in the control group (8.7% non-ICU, 28.8% ICU) compared to the Spirulina group (non-ICU HR, 0.13; 95% CI, 0.02 to 0.97; ICU, HR, 0.16; 95% CI, 0.05 to 0.48). In non-ICU, patients who received Spirulina showed a significant reduction in the levels of IL-6, TNF-α, IL-10, and IP-10 as intervention time increased. Furthermore, in ICU, patients who received Spirulina showed a significant decrease in the levels of MIP-1α and IL-6. IFN-γ levels were significantly higher in the intervention group in both ICU and non-ICU subgroups as intervention time increased. No side effects related to Spirulina supplements were observed during the trial.ConclusionHigh-dose Spirulina supplements coupled with the standard treatment of COVID-19 may improve recovery and remarkably reduce mortality in hospitalized patients with COVID-19.Clinical Trial Registrationhttps://irct.ir/trial/54375, Iranian Registry of Clinical Trials number (IRCT20210216050373N1

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

BACKGROUND: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. METHODS: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. FINDINGS: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. INTERPRETATION: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. FUNDING: The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38)

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe