Neurogenic Tumor of The Chest Wall: A

A rare case of schwannoma of the chest wall is presented. A 65-year-old Japanese man had a painful mass, measuring 3×3cm, in the 10th intercostal space of the right back. A fine needle biopsy seemed to fail to prove a nature of the tumor. A computed tomography (CT) scan of the chest showed a well-demarcated low density mass with no invasion to the ribs, lung and pleura with the CT density being 30 Hounsfield unit. These findings were suggestive of a neurogenic tumor. The tumor was easily extirpated and a histological diagnosis was schwannoma

Clinicopathological Study of Anal Canal Cancer

On the basis of a result of clinical experience with the treatment for patients with anal canal cancer, a clinicopathological study of anal canal cancer was performed in comparison with that of colon cancer. Anal canal cancer has a complex histologic types and a tendency toward deep invasion outside the adventitia when compared with colon cancer. Therefore, nodal involvement was in proportion to the depth of cancer infiltration. As a result, the survival time had become worst in patients with Dukes C of anal canal cancer. The anal canal has been defined that as a canal from the level of the attachment of puborectal muscle to the anal verge. It is mainly covered with smooth striated squamous epithelia except for the upper portion which is covered with specialized columnar epithelia, lasting to the rectal epithelium. The structure of the anal canal is complex with the composition of ecto-and endodermal tissues. Anal canal cancer is particular in gross appearance, histologic types and the modes of cancer extension in comparison with rectal cancer. This study defined the clinicopathological specificity of anal canal cancer on the basis of our clinical experience

Elderly infection in the community due to ST5/SCCmecII methicillin-resistant Staphylococcus aureus (the New York/Japan clone) in Japan: Panton–Valentine leukocidin-negative necrotizing pneumonia

An 89-year-old man suffered from and died of necrotizing pneumonia with rapid progression and cavity formation due to methicillin-resistant Staphylococcus aureus (MRSA). He was at no risk for hospital-acquired MRSA infection. His MRSA exhibited genotype ST5/spa2(t002)/agr2/SCCmecII/coagulaseII and was negative for Panton–Valentine leukocidin, indicating the New York/Japan clone (the predominant epidemic hospital-acquired MRSA clone in Japan). However, this strain expressed the cytolytic peptide (phenol-soluble modulin or δ-hemolysin) genes at high level, similar to USA300 (the most common community-acquired MRSA in the United States), indicating a variant of the New York/Japan clone with an important feature of community-acquired MRSA

Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues

AbstractExpression of the human pancreatic secretory trypsin inhibitor (PSTI) gene was examined in 24 cases of neoplastic tissues by Northern blot analyses. In three cases of lung adenocarcinoma and one case of sigmoid colon polyp, we detected transcripts which hybridized to the human PSTI cDNA probe. cDNA libraries were constructed using mRNAs of the two PSTI-positive tumor tissues. Two PSTI cDNA clones were obtained from each sample. Sequencing analyses showed that they were completely identical with that of pancreatic PSTI cDNA which had been reported [(1985) Biochem. Biophys. Res. Commun. 132, 605–612]. Southern blot analyses showed that the elevated expression of PSTI in neoplastic tissues was accompanied by neither PSTI gene amplification nor rearrangements

Surgical Treatment for Liver Cyst

We assess surgical treatment for seven patients with hepatic cyst on the basis of our clinical experience. It is emphasized to infer that surgical treatment is necessary for carcinoma arising from a cyst or suspcious one. It is also recommended that incidentally detected cysts should be treated with ethanol infusion under direct vision, if necessary, by using echoguided method. The operation method of deroofing except for complete resection is not necessarily guaranteed for large sized cysts

Castleman\u27s Disease of the Retroperitoneum

A case of retroperitoneal CASTLEMAN\u27s disease of hyaline-vascular type is presented. A 58-year-old woman was admitted with a four month history of lower back pain. Although a retroperitoneal tumor was found on sonography and CASTLEMAN\u27s disease was included in the differential diagnosis, further imaging procedures such as computed tomography and angiography could not confirm the preoperative diagnosis of CASTLEMAN\u27s disease. After the surgical removal of the tumor, the patient has been doing well with no evidence of recurrent disease

Prognostic value of metastin expression in human pancreatic cancer

<p>Abstract</p> <p>Background</p> <p><it>KiSS-1 </it>was identified as a metastasis-suppressing gene in melanoma cells. The <it>KiSS-1 </it>gene product (metastin) was isolated from human placenta as the ligand of GPR54, a G-protein-coupled receptor. The role of metastin and GPR54 in tumor progression is not fully understood.</p> <p>Methods</p> <p>We investigated the clinical significance of metastin and GPR54 expression in pancreatic cancer. We evaluated immunohistochemical expression of metastin and GPR54 in pancreatic ductal adenocarcinoma tissues obtained from 53 consecutive patients who underwent resection between July 2003 and May 2007 at Kyoto University Hospital. In 23 consecutive patients, the plasma metastin level was measured before surgery by enzyme immunoassay.</p> <p>Results</p> <p>Strong immunohistochemical expression of metastin was detected in 13 tumors (24.5%), while strong expression of GPR54 was detected in 30 tumors (56.6%). Tumors that were negative for both metastin and GPR54 expression were significantly larger than tumors that were positive for either metastin or GPR54 (p = 0.047). Recurrence was less frequent in patients who had metastin-positive tumors compared with those who had metastin-negative tumors (38.5% versus 70.0%, p = 0.04). Strong expression of metastin and GPR54 was significantly correlated with longer survival (p = 0.02). Metastin expression by pancreatic cancer was an independent prognostic factor for longer survival (hazard ratio, 2.1; 95% confidence interval, 1.1–4.7; p = 0.03), and the patients with a high plasma metastin level (n = 6) did not die after surgical resection.</p> <p>Conclusion</p> <p>Strong expression of metastin and GPR54 by pancreatic cancer is associated with longer survival. Metastin expression is an independent prognostic factor for the survival of pancreatic cancer patients. The plasma metastin level could become a noninvasive prognostic factor for the assessment of pancreatic cancer.</p

Free Perforation in Crohn\u27s Disease

Rare complication of free perforation in Crohn\u27s disease was clinically reviewed on the basis of surgical experiences with Crohn\u27s diseases. 1) Free perforation occurred in younger patients with steroid therapy. 2) There are no close correlation with the time duration of the disease affection. 3) The fortuitous locations of free perforation were the ileum and the ascending colon with multiple perforations. 4) One expired with postoperative sepsis on 55 days after surgery because of delay in diagnosis and treatment, although the other one was very well one year and one month following surgery. It was emphaseized that physicians should be aware of rare complication of free perforation in the follow-up of younger patients with Crohn\u27 disease in the use of steroid

Clinical Value of Flow Cytometric DNA analysis in colorectal cancers

The distribution of DNA in colon cancers and its relationship to factors related to clinical features of cancer invasion and noncurative operation are evaluated by using paraffin-embedded specimens. The survival in patients with DNA diploid tumor is apparently much more satisfactory than that in patients with aneuploid tumor in stage B and C patients in accordance with advances in the disease stage. The deeper the depth of cancer invasion reaches, the more the number of DNA aneuploid tumor increased in the distribution. Non-curative operation was more frequently made in patients with DNA aneuploid tumor rather than in patients with DNA diploid one. In conclusion, analysis of the distribution of DNA contributes to assessment of the prognosis of colorectal carcinoma in combination with conventional prognostic parameter of clinicopathologic variables

Nuclear DNA Analysis in Hepatocelular Carcinoma in Comparison with Clinicopathologic Factors

Nuclear DNA patterns were analyzed in the 33 patients with primary hepatocellular carcinoma on the basis of clinicopathologic standpoint. It is concluded that biologic behavior of hepatocellular cancer cells in patients with DNA aneuploidy pattern displayed highly malignant potential, indicating severe atypism, rapid growth of rupturing, the presence of cancer invasion into the wall of portal vein and distant metastasis. Furthermore, the survival time in patients with DNA aneuploidy pattern in hepatocellular carcinoma was shorter than that in patients with diploidy one