4 research outputs found
ЧЕЛОВЕЧЕСКИЙ КАПИТАЛ РЕГИОНА: ПРОБЛЕМЫ СУЩНОСТИ, СТРУКТУРЫ И ОЦЕНКИ
This article considers main questions appear in comtemporary circumstances while studying human capital on regional level: problems of understanding and aggregation, human capital structuring and assessment.В данной статье рассматриваются основные вопросы, которые возникают в современных условиях при исследовании человеческого капитала на региональном уровне: проблемы понимания и агрегирования, структурирования и оценки человеческого капитала
REGIONAL HUMAN CAPITAL: PROBLEMS OF ESSENCE, STRUCTURE AND ASSESSMENT
This article considers main questions appear in comtemporary circumstances while studying human capital on regional level: problems of understanding and aggregation, human capital structuring and assessment
Clusterin and Its Potential Regulatory microRNAs as a Part of Secretome for the Diagnosis of Abnormally Invasive Placenta: Accreta, Increta, and Percreta Cases
Magnetic resonance imaging (MRI) and ultrasound methods used for the diagnosis of an abnormally invasive placenta (AIP) have a wide range of sensitivity (Se, 33–93%) and specificity (Sp, 71–100%) levels, which results in a high risk of unfavorable maternal and perinatal outcomes. The relevance of optimizing the diagnosis of AIP is beyond doubt. Given the epigenetic nature of trophoblast invasion, we aimed to quantitate microRNAs and proteins of their target genes that are potentially associated with AIP in blood plasma samples from 64 pregnant women at gestation weeks 30–34 by reverse transcription coupled with polymerase chain reaction (RT-PCR) and Western blotting, respectively. Statistically significant increases in the expression levels of hsa-miR-17-5p, hsa-miR-21-5p, hsa-miR-25-3p, hsa-miR-92a-3p, and hsa-miR-320a-3p were revealed in the groups of women with AIP (accreta, increta, percreta) relative to the group of women with scars on the uterus or to the group with placenta previa. Opposite changes in the expression level of “gene–target protein/miRNA” pairs were found for the α-subunit of the clusterin secretory form and any of the hsa-miR-21-5p, hsa-miR-25-3p, hsa-miR-92a-3p, hsa-miR-320a-3p, and hsa-miR-17-5p in all cases of AIP. The developed logistic regression models to diagnose AIP cases of various severity gave Se values of 88.8–100% and Sp values of 91.6–100% using a combination of hsa-miR-21-5p, hsa-miR-92a-3p, hsa-miR-320a-3p, or clusterin levels