Measurement of redshift dependent cross correlation of HSC clusters and Fermi γ\gamma rays

The cross-correlation study of the unresolved $\gamma$-ray background (UGRB) with galaxy clusters has a potential to reveal the nature of the UGRB. In this paper, we perform a cross-correlation analysis between $\gamma$-ray data by the Fermi Large Area Telescope (Fermi-LAT) and a galaxy cluster catalogue from the Subaru Hyper Suprime-Cam (HSC) survey. The Subaru HSC cluster catalogue provides a wide and homogeneous large-scale structure distribution out to the high redshift at $z=1.1$, which has not been accessible in previous cross-correlation studies. We conduct the cross-correlation analysis not only for clusters in the all redshift range ($0.1 < z < 1.1$) of the survey, but also for subsamples of clusters divided into redshift bins, the low redshift bin ($0.1 < z < 0.6$) and the high redshift bin ($0.6 < z < 1.1$), to utilize the wide redshift coverage of the cluster catalogue. We find the evidence of the cross-correlation signals with the significance of 2.0-2.3$\sigma$ for all redshift and low-redshift cluster samples. On the other hand, for high-redshift clusters, we find the signal with weaker significance level (1.6-1.9$\sigma$). We also compare the observed cross-correlation functions with predictions of a theoretical model in which the UGRB originates from $\gamma$-ray emitters such as blazars, star-forming galaxies and radio galaxies. We find that the detected signal is consistent with the model prediction.Comment: 11 pages, 24 figures, accepted by MNRA

Detection of Asymptomatic Cardiac Metastasis and Successful Salvage Chemotherapy Comprising a Prednisone, Etoposide, Procarbazine, and Cyclophosphamide Regimen in an Elderly Japanese Patient Suffering from a Delayed Recurrence of Diffuse Large B-Cell Lymphoma

We report a case of facial diffuse large B-cell lymphoma (DLBCL) associated with recurrent metastasis in the heart and other sites in a 76-year-old Japanese woman. Initially, she developed DLBCL in her left upper eyelid that spread into the left orbit (Ann Arbor classification stage I). The lesion went into clinical regression after 4 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy followed by radiotherapy. More than 3 years later, the lymphoma recurred in her facial skin, together with metastases in the mediastinal lymph nodes and the heart; the tumor in the heart was successfully detected by PET/CT and cardiac MRI. To treat the recurrent lesions, we performed a salvage chemotherapy regimen comprising prednisone, etoposide, procarbazine, and cyclophosphamide, which successfully induced tumor regression

Tubulointerstitial Nephritis and Uveitis Syndrome Associated with Renal Tryptaseand Chymase-positive Mast Cell Infiltration

We report the clinical course and immunohistochemical analysis of a patient who presented with tubulointerstitial nephritis and uveitis syndrome (TINU syndrome). The patient, a 40-year-old woman, was referred to our hospital with general fatigue and a slight fever from another hospital. Mast cells are closely related to the development of renal interstitial fibrosis in patients with glomerulonephritis. To determine the role of mast cells in renal interstitial injury in TINU patients, we performed immunohistochemical studies on renal biopsy specimens using anti-human tryptase and anti-human chymase antibodies specific for mast cells. Double immunostaining of tryptase and chymase was also performed in renal tissues. In double immunofluorescence, cells with both chymase and tryptase (MCtc) were marked in the regions of interstitial fibrosis in this patient. It appears that mast cells are one of the constitutive cells of interstitial fibrosis in patients with TINU syndrome

Optimal Location of Two Laser-interferometric Detectors for Gravitational Wave Backgrounds at 100 MHz

Recently, observational searches for gravitational wave background (GWB) have been developed and given constraints on the energy density of GWB in a broad range of frequencies. These constraints have already resulted in the rejection of some theoretical models of relatively large GWB spectra. However, at 100 MHz, there is no strict upper limit from direct observation, though an indirect limit exists due to He4 abundance due to big-bang nucleosynthesis. In our previous paper, we investigated the detector designs that can effectively respond to GW at high frequencies, where the wavelength of GW is comparable to the size of a detector, and found that the configuration, a so-called synchronous-recycling interferometer is best at these sensitivity. In this paper, we investigated the optimal location of two synchronous-recycling interferometers and derived their cross-correlation sensitivity to GWB. We found that the sensitivity is nearly optimized and hardly changed if two coaligned detectors are located within a range 0.2 m, and that the sensitivity achievable in an experiment is far below compared with the constraint previously obtained in experiments.Comment: 17 pages, 6 figure

Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector

AbstractWe describe a robust expression of human stromal cell-derived factor-1α (SDF-1α) and SDF-1β, the members of CXC-chemokine family, with a novel vector system based upon Sendai virus, a non-segmented negative strand RNA virus. Recombinant SDF-1α and SDF-1β were detected as a major protein species in culture supernatants, reached as high as 10 μg/ml. This remarkable enrichment of the products allowed us to use even the crude supernatants as the source for biological and antiviral assays without further concentration nor purification and will thus greatly facilitate to screen their genetically engineered derivatives

Possible Usefulness of Gadolinium-Enhanced Brain MRI for Evaluating Risk of Perioperative Hemorrhage: A Case of Infective Endocarditis

A 59-year-old woman visited a local hospital for fever and was diagnosed as having infective endocarditis (IE) on the basis of blood cultures and transthoracic echocardiography. Based on clinical episodes of subarachnoid hemorrhage after admission, it was judged that she was not a good candidate for urgent open heart surgery, and it was decided to treat her with conservative medical therapy for the acute phase. We explored the optimum timing for surgery by employing gadolinium (Gd) contrast medium-enhanced magnetic resonance imaging (MRI) T2* weighted image (black dots) due to her high risk of perioperative cerebral hemorrhage. After the disappearance of the contrast media enhancement effect around the black dots, open heart surgery was performed successfully on the 103rd hospitalization day. The patient was discharged 22 days after the surgery with no clinical complications. This case suggests that disappearance of the contrast media enhancement effect around the black dots may be a useful marker for optimal timing of surgery to minimize the risk of perioperative cerebral hemorrhage in patients with IE. Learning Objective. The MRI T2* weighted images including those with Gd contrast medium enhancement effect may be useful for evaluating the risk of perioperative intracranial hemorrhage in IE

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article