1 research outputs found
Deliberately losing control of C-H activation processes in the design of small molecule fragment arrays targeting peroxisomal metabolism
Combined photochemical arylation, ânuisance effectâ (S N Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium throughput Xâray proteinâligand structure determination. Reactions have been deliberately let âout of control,â in terms of selectivity; for example the orthoâarylation of 2âphenylpyridine gave five products resulting from monoâ, bisâ arylations combined with S N Ar processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified