Is there a role for imatinib mesylate in the treatment of eosinophilic granulomatosis with polyangiitis?

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic eosinophilic vasculitis, belonging to the group of ANCA-associated vasculitides (AAV). EGPA pathogenesis is still elusive, but a potential role for IL-5 and Eotaxins mediated eosinophil activation has been reported. Imatinib mesylate, a tyrosine kinase (TK) inhibitor, is approved for the treatment of chronic myeloid leukaemia and FIP1L1/PDGFRA positive gene fusion hypereosinophilia. A potential role for imatinib in the treatment of idiopathic hypereosinophilic syndrome (HES) and AAV has been recently proposed

Copper Minerals at Vesuvius Volcano (Southern Italy): A Mineralogical Review

This work is part of a project focused on the Somma–Vesuvius volcano and aimed at identifying Cu minerals related to mineralizing processes associated with magmatic activity in an active magmatic-hydrothermal system. A mineralogical survey was carried out on a set of samples represented by sublimates and fumarolic products from the collection of the Mineralogical Museum of the University of Naples Federico II (Italy). These samples are mainly related to most recent eruptive episodes of Vesuvius activity, from 1631 onward. Copper-bearing minerals were characterized, as well as associated minerals, by X-ray diffraction (XRD) scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). An investigation on the structural complexity of Cu-mineral assemblages with different temperature formations was also carried out using the TOPOS software package. The main copper phases are sulfates, followed by vanadates, hydroxyhalides, oxides, carbonates, silicates and finally, phosphates. New mineral occurrences for Vesuvius, both Cu-bearing and Cu-free, are described. Nevertheless, the fumarolic/alteration minerals at Vesuvius cannot be considered of economic relevance as a copper reservoir, this type of mineralizations are significant for copper crystal chemistry and for the knowledge of the mineralogical variants. The obtained datasets can be of interest for the knowledge of volcanic byproducts of copper ore deposits (i.e., porphyry copper systems) and of (base) metal segregation processes