The development of an AIDS mucosal vaccine

It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces. Human immunodeficiency virus type one (HIV-1), a mainly sexually transmitted virus, also primarily targets the vaginal and gastrointestinal mucosa as entry sites for viral transmission, seeding, replication and amplification. Since HIV-1 establishes its early replication in vaginal or rectal mucosal tissues, the induction of sufficient mucosal immunity at the initial site of HIV-1 transmission becomes essential for a protective vaccine. However, despite the fact that current conventional vaccine strategies have remained unsuccessful in preventing HIV-1 infection, sufficient financial support and resources have yet to be given to develop a vaccine able to elicit protective mucosal immunity against sexual transmissions. Interestingly, Chinese ancestors invented variolation through intranasal administration about one thousand years ago, which led to the discovery of a successful smallpox vaccine and the final eradication of the disease. It is the hope for all mankind that the development of a mucosal AIDS vaccine will ultimately help control the AIDS pandemic. In order to discover an effective mucosal AIDS vaccine, it is necessary to have a deep understanding of mucosal immunology and to test various mucosal vaccination strategies. © 2010 by the authors.published_or_final_versio

Coherent optical binary polarisation shift keying heterodyne system in the free-space optical turbulence channel

In this paper, analytical and simulation results for the bit error rate (BER) performance and fading penalty of a coherent optical binary polarization shift keying (2PolSK) heterodyne system adopted for a free space optical (FSO) communication link modeled as the log-normal and the negative exponential atmospheric turbulence channels are presented. The conditional and unconditional BER expressions are derived, demonstrating the comprehensive similarity between the 2PolSK and the binary frequency shift keying (2FSK) schemes with regards to the system sensitivity. The power penalty due to the non-ideal polarization beam splitter (PBS) is also analyzed. The receiver sensitivity employing 2PolSK is compared with other modulation schemes in the presence of turbulence and the phase noise. The results show that 2PolSK offers improved signal-to-noise ratio (SNR) performance compared to the binary amplitude shift keying (2ASK)