Combination of Neutrophil Count and Gensini Score as a Prognostic Marker in Patients with ACS and Uncontrolled T2DM Undergoing PCI

Background: Several biomarkers have been studied as prognostic indicators among people with diabetes and coronary artery disease (CAD). The purpose of this study was to determine the prognostic value of neutrophil counts and the Gensini score in patients with diabetes and ACS undergoing percutaneous coronary intervention (PCI). Methods: A total of 694 people with ACS and T2DM who simultaneously had elevated HBA1c received PCI. Spearman rank correlation estimates were used for correlation evaluation. Multivariate Cox regression and Kaplan-Meier analysis were used to identify characteristics associated with major adverse cardiovascular and cerebrovascular events (MACCEs) and patient survival. The effects of single- and multi-factor indices on MACCEs were evaluated through receiver operating characteristic curve analysis. Results: The Gensini score and neutrophil count significantly differed between the MACCE and non-MACCE groups among patients receiving PCI who had concomitant ACS and T2DM with elevated HBA1c (P<0.001). The Gensini score and neutrophil count were strongly associated with MACCEs (log-rank, P<0.001). The Gensini score and neutrophil count, alone or in combination, were predictors of MACCEs, according to multivariate Cox regression analysis (adjusted hazard ratio [HR], 1.005; 95% confidence interval [CI], 1.002–1.008; P=0.002; adjusted HR, 1.512; 95% CI, 1.005–2.274; P=0.047, respectively). The Gensini score was strongly associated with neutrophil count (variance inflation factor ≥ 5). Area under the curve analysis revealed that the combination of multivariate factors predicted the occurrence of MACCEs better than any single variable. Conclusion: In patients with T2DM and ACS with elevated HBA1c who underwent PCI, both the Gensini score and neutrophil count were independent predictors of outcomes. The combination of both predictors has a higher predictability

Desalinization and salinization: a review of major challenges for coastal reservoirs

Coastal reservoirs are a possible solution to water supply and management issues in coastal zones. However, salinization can degrade the utility of such reservoirs. Two related major challenges affecting the operation of a coastal reservoir are desalinization and seawater intrusion. The former arises mainly during the period following reservoir construction, while the latter is ongoing. This review discusses the salt dynamics of coastal reservoirs under the influence of surface-water flows, river inflows, reservoir water level, and tides. Various salt transport processes are examined in relation to water salinity changes in coastal reservoirs. The methods and limitations of existing numerical models for coastal reservoirs are also discussed. Given the difficulty in reproducing realistic boundary conditions for laboratory experiments, further research needs to focus on investigations that consider salinization in real coastal reservoirs. More broadly, there remains a need to unravel the impacts of coastal reservoirs on the surrounding environment, as they can significantly change the hydrodynamics and chemical transport pathways in coastal waters. A comprehensive understanding of coastal reservoir salinization will improve water management and thus contribute to alleviating overexploitation of water resources in coastal zones

Research on the Constitutive Model of PTFE/Al/Si Reactive Material

As a new type of energetic material, reactive materials are widely used at present; in particular, the metal/polymer mixtures type reactive materials show great advantages in engineering applications. This type of reactive material has good mechanical properties, and its overall performance is insensitive and high-energy under external impact loading. After a large number of previous studies, our team found that the energy release characteristics of PTFE/Al/Si reactive material are prominent. In order to master the mechanical properties of PTFE/Al/Si reactive materials, the quasi-static mechanical properties and dynamic mechanical properties were obtained by carrying out a quasi-static compression test and a dynamic SHPB test in this paper. Based on the experimental data, a Johnson-Cook constitutive model of PTFE/Al/Si reactive material considering strain hardening effect, strain rate hardening effect and thermal softening effect was constructed. The relevant research results will be used to guide future research on the reaction mechanism of PTFE/Al/Si reactive materials, in order to promote the engineering application of PTFE/Al/Si reactive materials

Expression of a Cytochrome P450 Gene from Bermuda Grass <i>Cynodon dactylon</i> in Soybean Confers Tolerance to Multiple Herbicides

Bermuda grass (Cynodon dactylon) is notoriously difficult to control with some commonly used herbicides. We cloned a cytochrome P450 gene from Bermuda grass, named P450-N-Z1, which was found to confer tolerance to multiple herbicides in transgenic Arabidopsis. These herbicides include: (1) acetolactate synthase (ALS) inhibitor herbicides nicosulfuron and penoxsulam; (2) p-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicide mesotrione; (3) synthetic auxin herbicide dicamba; (4) photosynthesis inhibitor bentazon. We further generated transgenic soybean plants expressing P450-N-Z1, and found that these transgenic soybean plants gained robust tolerance to nicosulfuron, flazasulfuron, and 2,4-dichlorophenoxyacetic acid (2,4-D) in greenhouse assays. A field trial demonstrated that transgenic soybean is tolerant to flazasulfuron and 2,4-D at 4-fold and 2-fold the recommended rates, respectively. Furthermore, we also demonstrated that flazasulfuron and dicamba are much more rapidly degraded in vivo in the transgenic soybean than in non-transgenic soybean. Therefore, P450-N-Z1 may be utilized for engineering transgenic crops for herbicide tolerance

The Present Clinical Treatment and Future Emerging Interdisciplinary for Heart Failure: Where we are and What we can do

Abstract Heart failure is a complex clinical syndrome caused by the progression to severe stages of various cardiac diseases, characterized by high morbidity and mortality. With the increasing aging of the population and the poor control of high-risk factors for heart failure such as hypertension and diabetes, the incidence of heart failure remains high. Therefore, there is widespread global attention regarding the various treatments for heart failure. Currently, pharmacological therapy, associated device therapy, interventional therapy, and end-stage surgical related therapy are the main clinical treatments for heart failure. Heart failure treatment is gradually evolving to be more precise, safe, and effective, as traditional therapies can no longer match clinical needs. A number of cutting-edge research studies are being conducted on the treatment of heart failure, based on the different pathogenesis and causes of heart failure, to treat patients with heart failure in a multifaceted and integrated way. This article summarizes the current clinical treatment of heart failure and the latest therapeutic advances in heart failure in current research to further promote the standardized management and treatment of heart failure and improve patient prognosis