Deep learning radiomic nomogram can predict the number of lymph node metastasis in locally advanced gastric cancer: an international multi-center study.

BACKGROUND: Preoperative evaluation of the number of lymph node metastasis (LNM) is the basis of individual treatment of locally advanced gastric cancer (LAGC). However, the routinely used preoperative determination method is not accurate enough. PATIENTS AND METHODS: We enrolled 730 LAGC patients from 5 centers in China and 1 center in Italy, and divided them into 1 primary cohort, 3 external validation cohorts, and 1 international validation cohort. A deep learning radiomic nomogram (DLRN) was built based on the images from multi-phase computed tomography (CT) for preoperatively determining the number of LNM in LAGC. We comprehensively tested the DLRN and compared it with three state-of-the-art methods. Moreover, we investigated the value of the DLRN in survival analysis. RESULTS: The DLRN showed good discrimination of the number of LNM on all cohorts (overall C-indexes: 0.821, 95% CI: 0.785-0.858 in the primary cohort; 0.797, 95% CI: 0.771-0.823 in the external validation cohorts; and 0.822, 95% CI: 0.756-0.887 in the international validation cohort). The nomogram performed significantly better than the routinely used clinical N stages, tumor size, and clinical model (p<0.05). Besides, DLRN is significantly associated with the overall survival of LAGC patients (n=271). CONCLUSION: A deep learning-based radiomic nomogram had good predictive value for LNM in LAGC. In staging-oriented treatment of gastric cancer, this preoperative nomogram could provide baseline information for individual treatment of LAGC

Observation of Y(2175) in J/ψ→ηϕf0(980)J/\psi\to \eta\phi f_0(980)

The decays of $J/\psi\to \eta\phi f_0(980) (\eta\to \gamma\gamma, \phi \to K^+K^-, f_0(980)\to\pi^+\pi^-)$ are analyzed using a sample of $5.8 \times 10^{7}$ $J/\psi$ events collected with the BESII detector at the Beijing Electron-Positron Collider (BEPC). A structure at around $2.18$GeV/$c^2$ with about $5\sigma$ significance is observed in the $\phi f_0(980)$ invariant mass spectrum. A fit with a Breit-Wigner function gives the peak mass and width of $m=2.186\pm 0.010 (stat)\pm 0.006 (syst)$GeV/$c^2$ and $\Gamma=0.065\pm 0.023 (stat)\pm 0.017 (syst)$GeV/$c^2$, respectively, that are consistent with those of Y(2175), observed by the BABAR collaboration in the initial-state radiation (ISR) process $e^+e^-\to\gamma_{ISR}\phi f_0(980)$. The production branching ratio is determined to be $Br(J/\psi\to\eta Y(2175))\cdot Br(Y(2175)\to\phi f_0(980))\cdot Br(f_0(980)\to\pi^+\pi^-)=(3.23\pm 0.75 (stat)\pm0.73 (syst))\times 10^{-4}$, assuming that the Y(2175) is a $1^{--}$ state.Comment: 5 pages, 4 figures, accepted by Phys. Rev. Let

A Unified Approach to the Classical Statistical Analysis of Small Signals

We give a classical confidence belt construction which unifies the treatment of upper confidence limits for null results and two-sided confidence intervals for non-null results. The unified treatment solves a problem (apparently not previously recognized) that the choice of upper limit or two-sided intervals leads to intervals which are not confidence intervals if the choice is based on the data. We apply the construction to two related problems which have recently been a battle-ground between classical and Bayesian statistics: Poisson processes with background, and Gaussian errors with a bounded physical region. In contrast with the usual classical construction for upper limits, our construction avoids unphysical confidence intervals. In contrast with some popular Bayesian intervals, our intervals eliminate conservatism (frequentist coverage greater than the stated confidence) in the Gaussian case and reduce it to a level dictated by discreteness in the Poisson case. We generalize the method in order to apply it to analysis of experiments searching for neutrino oscillations. We show that this technique both gives correct coverage and is powerful, while other classical techniques that have been used by neutrino oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with published version. A few small changes, plus the two substantive changes we made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C). It was inconsistent with our actual definition in Sec. VI. 2) "Note added in proof" at end of the Conclusio

Measurement of \psip Radiative Decays

Using 14 million psi(2S) events accumulated at the BESII detector, we report first measurements of branching fractions or upper limits for psi(2S) decays into gamma ppbar, gamma 2(pi^+pi^-), gamma K_s K^-pi^++c.c., gamma K^+ K^- pi^+pi^-, gamma K^{*0} K^- pi^+ +c.c., gamma K^{*0}\bar K^{*0}, gamma pi^+pi^- p pbar, gamma 2(K^+K^-), gamma 3(pi^+pi^-), and gamma 2(pi^+pi^-)K^+K^- with the invariant mass of hadrons below 2.9GeV/c^2. We also report branching fractions of psi(2S) decays into 2(pi^+pi^-) pi^0, omega pi^+pi^-, omega f_2(1270), b_1^\pm pi^\mp, and pi^0 2(pi^+pi^-) K^+K^-.Comment: 5 pages, 4 figure

Measurements of J/ψJ/\psi and ψ(2S)\psi(2S) decays into ΛΛˉπ0\Lambda \bar{\Lambda}\pi^0 and ΛΛˉη\Lambda \bar{\Lambda}\eta

Using 58 million $J/\psi$ and 14 million $\psi(2S)$ events collected by the BESII detector at the BEPC, branching fractions or upper limits for the decays $J/\psi$ and $\psi(2S) \to \Lambda \bar{\Lambda}\pi^0$ and $\Lambda \bar{\Lambda}\eta$ are measured. For the isospin violating decays, the upper limits are determined to be ${\cal B}(J/\psi \to \Lambda \bar{\Lambda}\pi^0)<6.4\times 10^{-5}$ and ${\cal B}(\psi(2S) \to \Lambda \bar{\Lambda}\pi^0)<4.9\times 10^{-5}$ at the 90% confidence level. The isospin conserving process $J/\psi \to \Lambda \bar{\Lambda}\eta$ is observed for the first time, and its branching fraction is measured to be ${\cal B}(J/\psi \to \Lambda \bar{\Lambda}\eta)=(2.62\pm 0.60\pm 0.44)\times 10^{-4}$, where the first error is statistical and the second one is systematic. No $\Lambda \bar{\Lambda}\eta$ signal is observed in $\psi(2S)$ decays, and ${\cal B}(\psi(2S) \to \Lambda \bar{\Lambda}\eta)<1.2\times 10^{-4}$ is set at the 90% confidence level. Branching fractions of $J/\psi$ decays into $\Sigma^+ \pi^- bar{\Lambda}$ and $\bar{\Sigma}^- \pi^+ \Lambda$ are also reported, and the sum of these branching fractions is determined to be ${\cal B}(J/\psi \to \Sigma^+\pi^- \bar{\Lambda} + c.c.)=(1.52\pm 0.08\pm 0.16)\times 10^{-3}$.Comment: 7 pages, 10 figures. Phys.Rev.D comments considere

Measurements of the continuum RudsR_{\rm uds} and RR values in e+e−e^+e^- annihilation in the energy region between 3.650 and 3.872 GeV

We report measurents of the continuum $R_{\rm uds}$ near the center-of-mass energy of 3.70 GeV, the $R_{{\rm uds(c)}+\psi(3770)}(s)$ and the $R_{\rm had}(s)$ values in $e^+e^-$ annihilation at 68 energy points in the energy region between 3.650 and 3.872 GeV with the BES-II detector at the BEPC Collodier. We obtain the $R_{\rm uds}$ for the continuum light hadron (containing u, d and s quarks) production near the $D\bar D$ threshold to be $R_{\rm uds}=2.141 \pm 0.025 \pm 0.085$.Comment: 5 pages, 3 figure

Search for psi(3770)\ra\rho\pi at the BESII detector at the Beijing Electron-Positron Collider

Non-$D\bar{D}$ decay \psppto \rhopi is searched for using a data sample of $(17.3\pm 0.5) pb^{-1}$ taken at the center-of-mass energy of 3.773 GeV by the BESII detector at the BEPC. No \rhopi signal is observed, and the upper limit of the cross section is measured to be \sigma(\EETO \rhopi)<6.0 pb at 90% C. L. Considering the interference between the continuum amplitude and the \pspp resonance amplitude, the branching fraction of \pspp decays to $\rho\pi$ is determined to be \BR(\pspp\ra\rho\pi)\in(6.0\times10^{-6}, 2.4\times10^{-3}) at 90% C. L. This is in agreement with the prediction of the $S$- and $D$-wave mixing scheme of the charmonium states for solving the ``\rhopi puzzle'' between \jpsi and \psp decays.Comment: 15 pages, 5 figure

Measurement of the branching fractions of psi(2S) -> 3(pi+pi-) and J/psi -> 2(pi+pi-)

Using data samples collected at sqrt(s) = 3.686GeV and 3.650GeV by the BESII detector at the BEPC, the branching fraction of psi(2S) -> 3(pi+pi-) is measured to be [4.83 +- 0.38(stat) +- 0.69(syst)] x 10^-4, and the relative branching fraction of J/psi -> 2(pi+pi-) to that of J/psi -> mu+mu- is measured to be [5.86 +- 0.19(stat) +- 0.39(syst)]% via psi(2S) -> (pi+pi-)J/psi, J/psi -> 2(pi+pi-). The electromagnetic form factor of 3(pi+pi-) is determined to be 0.21 +- 0.02 and 0.20 +- 0.01 at sqrt(s) = 3.686GeV and 3.650GeV, respectively.Comment: 17pages, 7 figures, submitted to Phys. Rev.

Experimental study of ψ(2S)\psi(2S) decays to \K^+ K^- \pi^+ \pi^- \pi^0 final states

$K^+K^-\pi^+\pi^-\pi^0$ final states are studied using a sample of $14\times10^6$ $\psi(2S)$ decays collected with the Beijing Spectrometer (BESII) at the Beijing Electron-Position Collider. The branching fractions of $\psi(2S)$ decays to $K^+K^-\pi^+\pi^-\pi^0$, $\omega K^+ K^-$, $\omega f_0(1710)$, $K^{\ast}(892)^0 K^- \pi^+\pi^0+c.c.$, $K^{\ast}(892)^{+} K^- \pi^+\pi^- +c.c.$, $K^{\ast}(892)^{+} K^- \rho^0+c.c.$ and $K^{\ast}(892)^0 K^-\rho^+ + c.c.$ are determined. The first two agree with previous measurements, and the last five are first measurements.Comment: 19 pages, 9 figure

First observation of ψ(2S)→pnˉπ−+c.c.\psi(2S) \to p \bar{n} \pi^- +c.c.

Using 14 million $\psi(2S)$ events collected with the Beijing Spectrometer (BESII) at the Beijing Electron-Positron Collider, the branching fractions of $\psi(2S)$ decays to $p \bar{n} \pi^-$ and $\bar{p} n \pi^+$ and the branching fractions of the main background channels $\psi(2S) \to p \bar{n} \pi^-\pi^0$, $\psi(2S) \to \gamma\chi_{c0} \to \gamma p \bar{n} \pi^-$, $\psi(2S) \to \gamma\chi_{c2} \to \gamma p \bar{n} \pi^-$, and $\psi(2S) \to \gamma \chi_{cJ} \to \gamma p \bar{n} \pi^- \pi^0$ are determined. The contributions of the $N^{\ast}$ resonances in $\psi(2S) \to p \bar{n} \pi^- +c.c.$ are also discussed.Comment: 19 pages, 8 figures, add vertex requirement systematic erro