Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong

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Simbolismos, Memórias e Narrativas: Redescobrindo a Rua da Lama da Década de 1980

Esta pesquisa teve por objetivo revelar aspectos simbólicos relacionados ao passado de um espaço na cidade de Vitória/ES, a Rua da Lama, a partir de pessoas que a frequentaram na década de 1980. Esta década foi escolhida por se tratar do início dessa região emblemática na cidade, que até hoje permanece sendo um ponto de encontro de lazer das pessoas. O que torna tal espaço contemporâneo e muito frequentado dentro da cidade. O estudo buscou relacionar os aspectos simbólicos de tal espaço, manifestados nas memórias presentes nas narrativas de seus antigos frequentadores. O objeto de pesquisa, composto por diferentes tipos de organizações, foi definido como espaço organizacional. Devido à complexidade do tema, buscou-se um aporte interdisciplinar dentro dos Estudos Organizacionais, abarcando as Ciências Sociais, História e o referencial de memória na Administração. Para o empreendimento, à luz de uma abordagem interdisciplinar nos Estudos Organizacionais, foi desenvolvida uma pesquisa de cunho qualitativo, utilizando a técnica de entrevistas narrativas para a coleta dos dados, gerando um conteúdo denso, que foram transcritas para posterior análise. Esse tipo de entrevista permitiu a pesquisadora entender de forma mais profunda o universo pesquisado. Após a coleta dos dados, o tratamento foi feito através da análise de conteúdo com as categorizações a posteriori. O período de coleta de dados se deu de maio a outubro de 2015, no qual foram realizadas oito entrevistas narrativas. Como resultado, foram encontradas três categorias seguindo um percurso temático, nomeadas por: O rock da Lama; As diferentes relações simbólicas com o espaço da Lama da década de 1980 e A Rua da Lama como um espaço de transgressão. A reflexão deu conta dos diferentes usos do passado para a reapropriação dos espaços simbólicos

Toll-like receptor 4 mediates tubular inflammation in diabetic nephropathy

published_or_final_versionThe 15th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 39, abstract no. 6

Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications

Background: Health-related quality of life (HRQoL) and health preference of patients with diabetes mellitus (DM) are essential in health economic evaluations but data on Chinese population is rare. This study aims to evaluate HRQoL and health preference of diabetic patients with different diabetic complications in Chinese population. Methods: A cross-sectional study was conducted in 1275 patients with DM, including 518 subjects with various DM-related complications. HRQoL and health preference were estimated using SF-12 and SF-6D questionnaires, respectively. Disease status of DM and complications were identified from documented clinical diagnosis. Multivariable regression was used to investigate the effects of specific complications on HRQoL and health preference, adjusting for socio-demographic and clinical parameters. Results: The presence of any diabetic complication was associated with lower physical component summary (−3.81 points, P < 0.01), and end-stage renal disease (ESRD) showed greatest reduction (−7.05 points, P < 0.01). Mental component summary and mental health (MH) scores were not decreased in any of the diabetic complications. The health preference score for diabetic subjects without complications was 0.882 (95% CI, 0.778 to 0.989). The reductions of health preference score were significant for stroke (−0.042, 95% CI -0.072 to −0.012), ESRD (−0.055, 95% CI -0.093 to −0.017), and sight-threatening diabetic retinopathy (STDR) (−0.043, 95% CI -0.075 to −0.010), while heart disease had an insignificant reduction (−0.017, 95% CI -0.042 to 0.008). Conclusions: The presence of any of the four major diabetic complications (heart disease, stroke, ESRD and STDR) was associated with lower HRQoL and health preference scores. Findings of this study facilitated the cost-effectiveness studies of alternative management strategies for prevention of diabetic complications in Chinese population.published_or_final_versio

Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success

Renal transplant recipients (RTRs) are subject to a variety of opportunistic infections. We present a rare case of varicella zoster virus-derived progressive outer retinal necrosis in an RTR, who presented with painless visual blurring. This clinical entity heralds an extremely poor visual prognosis and is an important condition to consider in any immunocompromised host. Early diagnosis by aqueous fluid sampling and immediate institution of combined systemic and intravitreal antiviral therapy was successful in this individual.postprin

Research on the allelopathic potential of wheat

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Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.

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