Optical properties of Si/Si0.87Ge0.13 multiple quantum well wires

Nanometer-scale wires cut into a Si/Si0.87Ge0.13 multiple quantum well structure were fabricated and characterized by using photoluminescence and photoreflectance at temperatures between 4 and 20 K. It was found that, in addition to a low-energy broadband emission at around 0.8 eV and other features normally observable in photoluminescence measurements, fabrication process induced strain relaxation and enhanced electron-hole droplets emission together with a new feature at 1.131 eV at 4 K were observed. The latter was further identified as a transition related to impurities located at the Si/Si0.87Ge0.13 heterointerfaces

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer

Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation. To overcome this problem, we analysed the metabonomic differences between two independent pairs of erlotinib-sensitive/resistant cells and discovered that glutathione (GSH) levels were significantly reduced in T790M EGFR cells. We also found that increasing GSH levels in erlotinib-resistant cells re-sensitised them, whereas reducing GSH levels in erlotinib-sensitive cells made them resistant. Decreased transcription of the GSH-synthesising enzymes (GCLC and GSS) due to the inhibition of NRF2 was responsible for low GSH levels in resistant cells that was directly linked to the T790M mutation. T790M EGFR clinical samples also showed decreased expression of these key enzymes; increasing intra-tumoural GSH levels with a small-molecule GST inhibitor re-sensitised resistant tumours to erlotinib in mice. Thus, we identified a new resistance pathway controlled by EGFR T790M and a therapeutic strategy to tackle this problem in the clinic

Coupled Oscillators with Chemotaxis

A simple coupled oscillator system with chemotaxis is introduced to study morphogenesis of cellular slime molds. The model successfuly explains the migration of pseudoplasmodium which has been experimentally predicted to be lead by cells with higher intrinsic frequencies. Results obtained predict that its velocity attains its maximum value in the interface region between total locking and partial locking and also suggest possible roles played by partial synchrony during multicellular development.Comment: 4 pages, 5 figures, latex using jpsj.sty and epsf.sty, to appear in J. Phys. Soc. Jpn. 67 (1998

Vortex avalanches and self organized criticality in superconducting niobium

In 1993 Tang proposed [1] that vortex avalanches should produce a self organized critical state in superconductors, but conclusive evidence for this has heretofore been lacking. In the present paper, we report extensive micro-Hall probe data from the vortex dynamics in superconducting niobium, where a broad distribution of avalanche sizes scaling as a power-law for more than two decades is found. The measurements are combined with magneto-optical imaging, and show that over a widely varying magnetic landscape the scaling behaviour does not change, hence establishing that the dynamics of superconducting vortices is a SOC phenomenon.Comment: 3 pages + 4 figures, a reference added, citation typos fixe

Self-organization of vortices in type-II superconductors during magnetic relaxation

We revise the applicability of the theory of self-organized criticality (SOC) to the process of magnetic relaxation in type-II superconductors. The driving parameter of self-organization of vortices is the energy barrier for flux creep and not the current density. The power spectrum of the magnetic noise due to vortex avalanches is calculated and is predicted to vary with time during relaxation.Comment: RevTex, 5 pages, 2 PS figures. Accepted in Phys. Rev.

Multi-wavelength emissions from the millisecond pulsar binary PSR J1023+0038 during an accretion active state

Recent observations strongly suggest that the millisecond pulsar binary PSR J1023+0038 has developed an accretion disk since 2013 June. We present a multi-wavelength analysis of PSR J1023+0038, which reveals that 1) its gamma-rays suddenly brightened within a few days in June/July 2013 and has remained at a high gamma-ray state for several months; 2) both UV and X-ray fluxes have increased by roughly an order of magnitude, and 3) the spectral energy distribution has changed significantly after the gamma-ray sudden flux change. Time variabilities associated with UV and X-rays are on the order of 100-500 seconds and 50-100 seconds, respectively. Our model suggests that a newly formed accretion disk due to the sudden increase of the stellar wind could explain the changes of all these observed features. The increase of UV is emitted from the disk, and a new component in gamma-rays is produced by inverse Compton scattering between the new UV component and pulsar wind. The increase of X-rays results from the enhancement of injection pulsar wind energy into the intra-binary shock due to the increase of the stellar wind. We also predict that the radio pulses may be blocked by the evaporated winds from the disk and the pulsar is still powered by rotation.Comment: 8 pages, 3 figures; accepted for publication in Ap

4He experiments can serve as a database for determining the three-nucleon force

We report on microscopic calculations for the 4He compound system in the framework of the resonating group model employing realistic nucleon-nucleon and three nucleon forces. The resulting scattering phase shifts are compared to those of a comprehensive R-matrix analysis of all data in this system, which are available in numerical form. The agreement between calculation and analysis is in most cases very good. Adding three-nucleon forces yields in many cases large effects. For a few cases the new agreement is striking. We relate some differencies between calculation and analysis to specific data and discuss neccessary experiments to clarify the situation. From the results we conclude that the data of the 4He system might be well suited to determine the structure of the three-nucleon force.Comment: title changed,note added, format of figures changed, appearance of figures in black-and-white changed, Phys. Rev. C accepte

The Chromo-Dielectric Soliton Model: Quark Self Energy and Hadron Bags

The chromo-dielectric soliton model (CDM) is Lorentz- and chirally-invariant. It has been demonstrated to exhibit dynamical chiral symmetry breaking and spatial confinement in the locally uniform approximation. We here study the full nonlocal quark self energy in a color-dielectric medium modeled by a two parameter Fermi function. Here color confinement is manifest. The self energy thus obtained is used to calculate quark wave functions in the medium which, in turn, are used to calculate the nucleon and pion masses in the one gluon exchange approximation. The nucleon mass is fixed to its empirical value using scaling arguments; the pion mass (for massless current quarks) turns out to be small but non-zero, depending on the model parameters.Comment: 24 pages, figures available from the author

Multi-Modes Phonon Softening in Two-Dimensional Electron-Lattice System

Phonon dispersion in a two-dimensional electron-lattice system described by a two-dimensional square-lattice version of Su-Schrieffer-Heeger's model and having the half-filled electronic band is studied theoretically at temperatures higher than the mean field critical temperature of the Peierls transition. When the temperature is lowered from the higher region down to the critical one, softening of multi phonon modes which have wave vectors equal to the nesting vector \vv{Q}=(\pi/a,\pi/a) with $a$ the lattice constant or parallel to \vv{Q} is observed. Although both of the transverse and longitudinal modes are softened at the critical temperature in the case of the wave vector equal to \vv{Q}, only the transverse modes are softened for other wave vectors parallel to \vv{Q}. This behavior is consistent with the Peierls distortions at lower temperatures.Comment: 10 pages, 5 Figure

An Exactly Solvable Anisotropic Directed Percolation Model in Three Dimensions

We solve exactly a special case of the anisotropic directed bond percolation problem in three dimensions, in which the occupation probability is 1 along two spatial directions, by mapping it to a five-vertex model. We determine the asymptotic shape of the ininite cluster and hence the direction dependent critical probability. The exponents characterising the fluctuations of the boundary of the wetted cluster in d-dimensions are related to those of the (d-2)-dimensional KPZ equation.Comment: 4 pages, RevTex, 4 figures. 1 reference added, minor change