Deflections of Laterally Loaded Square Plates under Various Edge Conditions

In this paper, the authors calculated the deflections of laterally loaded square plates under various edge conditions. The authors treated the problem assuming the plate is clamped or supported at the edges and deriving a fundamental solution suitable to any boundary condition, determined the coefficients included in the solution by the various boundary conditions

Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases: Current Perspectives and Future Directions

Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6, when transiently produced, contributes to host defense against acute environmental stress, continuous dysregulated IL-6 production plays a significant pathological role in several systemic autoimmune diseases. In response to the expectation that IL-6 blockade would constitute a novel therapeutic strategy for the treatment of these diseases, tocilizumab, a humanized anti-IL-6 receptor antibody, was developed. Clinical trials have verified the efficacy and the safety of tocilizumab for patients with rheumatoid arthritis, resulting in approval of this innovative biologic for the treatment of rheumatoid arthritis in more than 90 countries worldwide. Pathological analyses of the effect of IL-6 on the development of autoimmune diseases and a considerable number of case reports and pilot studies have also indicated the beneficial effects of this antibody on other systemic autoimmune diseases, including systemic lupus erythematosus, systemic sclerosis, polymyositis, and large-vessel vasculitis

Low-Resolution Spectrum of the Diffuse Galactic Light and 3.3 um PAH emission with AKARI InfraRed Camera

We first obtained the spectrum of the diffuse Galactic light (DGL) at general interstellar space in 1.8-5.3 um wavelength region with the low-resolution prism spectroscopy mode of the AKARI Infra-Red Camera (IRC) NIR channel. The 3.3 um PAH band is detected in the DGL spectrum at Galactic latitude |b| < 15 deg, and its correlations with the Galactic dust and gas are confirmed. The correlation between the 3.3 um PAH band and the thermal emission from the Galactic dust is expressed not by a simple linear correlation but by a relation with extinction. Using this correlation, the spectral shape of DGL at optically thin region (5 deg < |b| < 15 deg) was derived as a template spectrum. Assuming that the spectral shape of this template spectrum is uniform at any position, DGL spectrum can be estimated by scaling this template spectrum using the correlation between the 3.3 um PAH band and the thermal emission from the Galactic dust.Comment: 7 pages, 5 figures, accepted by Publications of the Astronomical Society of Japan (PASJ