Pseudo-gapping: Evidence for Overt Quantifier Raising

This paper explores the grammatical process of pseudo-gapping. In the literature, pseudo-gapping has been analyzed as a series of two operations: the syntactic movement of a remnant out of a VP (Move-R) and the phonological deletion of the VP (VP-deletion). Given this movement + deletion theory, I address what type of movement Move-R is. This paper makes a new argument against Takahashi’s (2004) approach, and for Johnson’s (2008) approach; the former identifies Move-R with the combination of Heavy NP Shift and Object Shift, while the latter identifies it with Quantifier Raising (QR), whose output is covert in general cases. Specifically, it is shown that the latter, but not the former, can predict two facts: that the object of a preposition in an NP-PP argument construction can be a remnant and that no predicate NP can be a remnant. The QR approach is then extended by adopting the single output model of syntax (e.g., Bobaljik 1995). In particular, a new phonological theory of QR is proposed, which provides four possible ways to reduce the chain of QR, depending on whether VP-deletion applies and whether the moved element is focused. This new theory is shown to explain why the output of QR can be overt in pseudo-gapping. Considering the possibility of overt QR, this paper concludes by arguing against the traditional T model of grammar, or the dual output model of syntax (e.g., Chomsky and Lasnik 1977)

Internal Merge to the Phase Edge in Pseudo-gapping

Special Volume on the Occasion of the Retirement in 2019 of Professor Yukio Ob

Cytomegalovirus as an Insidious Pathogen Causing Duodenitis

A 60-year-old woman with rheumatoid arthritis treated with methotrexate for a decade complained of slight epigastric discomfort. A positive cytomegalovirus (CMV) antigenemia test indicated the probability of CMV-related gastrointestinal infection, for which esophagogastroduodenoscopy was performed. Endoscopic findings showed a non-specific duodenal mucosal lesion;however, pathological investigation revealed evidence of CMV duodenitis. There is scarce information on the clinical and pathological features of CMV-related duodenitis, likely due to its low prevalence. CMV infection in the upper gastrointestinal tract should be considered as a differential diagnosis in high-risk individuals, particularly those with symptoms relating to the digestive system. Biopsy examinations are preferable for the definitive diagnosis of CMV gastrointestinal infection, even without specific endoscopic features

Photoperiodic diapause under the control of circadian clock genes in an insect

<p>Abstract</p> <p>Background</p> <p>Most organisms have evolved a circadian clock in order to anticipate daily environmental changes and many of these organisms are also capable of sophisticated measurement of daylength (photoperiodism) that is used to regulate seasonal events such as diapause, migration and polymorphism. It has been generally accepted that the same elements are involved in both circadian (daily) and seasonal (annual) rhythms because both rely upon daily light-dark cycles. However, as reasonable as this sounds, there remains no conclusive evidence of such a molecular machinery in insects. We have approached this issue by using RNA interference (RNAi) in <it>Riptortus pedestris</it>.</p> <p>Results</p> <p>The cuticle deposition rhythm exhibited the major properties of circadian rhythms, indicating that the rhythm is regulated by a circadian clock. RNAi directed against the circadian clock genes of <it>period </it>and <it>cycle</it>, which are negative and positive regulators in the circadian clock, respectively, disrupted the cuticle deposition rhythm and distinct cuticle layers were produced by these RNAi. Simultaneously, <it>period </it>RNAi caused the insect to avert diapause under a diapause-inducing photoperiod whereas <it>cycle </it>RNAi induced diapause under a diapause-averting photoperiod. The expression patterns of juvenile hormone-regulated genes and the application of juvenile hormone analogue suggested that neither ovarian development itself nor a downstream cascade of juvenile hormone secretion, were disturbed by <it>period </it>and <it>cycle </it>RNAi.</p> <p>Conclusions</p> <p>This study revealed that the circadian clock genes are crucial not only for daily rhythms but also for photoperiodic diapause. RNAi directed against <it>period </it>and <it>cycle </it>had opposite effects not only in the circadian cuticle deposition rhythm but also in the photoperiodic diapause. These RNAi also had opposite effects on juvenile hormone-regulated gene expression. It is still possible that the circadian clock genes pleiotropically affect ovarian development but, based on these results, we suggest that the circadian clock operated by the circadian clock genes, <it>period </it>and <it>cycle</it>, governs seasonal timing as well as the daily rhythms.</p> <p>See Commentary: <url>http://www.biomedcentral.com/1741-7007/8/115</url></p

COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature

A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. The patient, however, continued to have fever and malaise and showed a high level of serum soluble interleukin-2 receptor (sIL-2R) even 4 weeks after the second vaccination. Computed tomographic scan disclosed mediastinal and bilateral hilar small lymphadenopathy together with limited granular lesion in the right lung. Gallium-67 scintigraphy demonstrated high uptake not only in mediastinal and hilar lymph nodes but also in bilateral parotid glands. Right parotid gland biopsy revealed noncaseating granulomas and proved pathological diagnosis of sarcoidosis. The systemic symptoms were relieved by oral prednisolone 20 mg daily. Even though the causal relationship remains undetermined, this case is unique at the point that vaccine-associated uveitis led to the detection of pulmonary lesions and lymphadenopathy, resulting in clinical and pathological diagnosis of sarcoidosis. In literature review, 3 patients showed sarcoidosis-like diseases after COVID-19 vaccination: 2 patients were diagnosed clinically as Lofgren syndrome with acute onset of erythema nodosum and ankle swelling, with or without mediastinal and hilar lymphadenopathy, whereas 1 patient with mediastinal lymphadenopathy but no uveitis was diagnosed pathologically by biopsy as sarcoidosis. </jats:p