ゲンシカク : ゲンシカクノアイダノソウゴサヨウノケンキュウ

京都大学0048新制・課程博士工学博士甲第1603号工博第415号新制||工||304(附属図書館)4101UT51-50-E27京都大学大学院工学研究科原子核工学専攻(主査)教授 片山 泰久, 教授 向坂 正勝, 教授 清水 栄学位規則第5条第1項該当Kyoto UniversityDA

Ultrastructural Study of Human Adrenal Cortical Hyperplasia in Cushing's Syndrome.

Light and electron microscopic changes of hyperplastic adrenal cortices from two patients with Cushing's syndrome were reported. The ultrastructural findings were characterized by the increase of lipid inclusions, a large number of intochondria, vacuoles in mitochondria and also the increase of sER in some cells. Observations of the intramitochondrial vasuoles support the view that steriod sythesis may take place within the mitochondria, but their biological significance still remains to be elucidated

An Ecological Approach to Interface Design

Four approaches to interface design are considered: technology centered, user centered, control centered, and use centered (ecological). Each perspective provides unique insights into pieces of the interface design problem. However, it is argued that the ecological or use centered approach provides a more comprehensive framework within which the other three perspectives can play important supporting roles. This approach goes beyond issues of information requirements to address meaning as an emergent property of a dynamic work ecology

An Ecological Approach to Interface Design

Four approaches to interface design are considered: technology centered, user centered, control centered, and use centered (ecological). Each perspective provides unique insights into pieces of the interface design problem. However, it is argued that the ecological or use centered approach provides a more comprehensive framework within which the other three perspectives can play important supporting roles. This approach goes beyond issues of information requirements to address meaning as an emergent property of a dynamic work ecology

A case of primary orbital liposarcoma with dedifferentiated transformation from a well-differentiated form

Purpose: Primary orbital liposarcomas are rare. To the best of our knowledge, only four cases of primary dedifferentiated liposarcomas of the orbit have been reported. Furthermore, there have been no reports of primary orbital liposarcomas transitioning from a highly differentiated to a dedifferentiated form. Here, we report a case of primary orbital liposarcoma that was well-differentiated at the time of initial resection at our hospital but had dedifferentiated on recurrence 10 years after the initial resection. Observations: The patient was diagnosed with an inflammatory mass after an initial tumor resection by a previous physician at age 52. Thereafter, there were four recurrences (first to fourth recurrences), and the patient underwent five surgeries and radiotherapy. For the fifth recurrence, he first visited our hospital at age 64 and was diagnosed with a well-differentiated liposarcoma after undergoing tumor resection. When the tumor recurred 9 years later (the sixth recurrence), it was well-differentiated. When the tumor recurred (the seventh recurrence) six months after surgery at the age of 73 years, the patient underwent orbital exenteration because of rapid tumor growth, and pathological examination showed that the tissue had changed to a dedifferentiated liposarcoma. Conclusions and Importance: Primary well-differentiated orbital liposarcoma may transform to a dedifferentiated form over time. The risk of dedifferentiation at recurrence should be considered in developing a treatment plan, even if the initial pathology is a well-differentiated liposarcoma