A data-driven method to reduce excessive contact pressure of hand orthosis using a soft sensor skin

Discomfort under customised hand orthosis has been commonly reported in clinics due to excessive contact pressures, leading to low patient adherence and decreased effectiveness of orthosis. However, the current orthosis adjustment by clinicians to reduce pressures based upon subjective feedback from patients is inefficient and prone to variability. Therefore, a quantitative method to guide orthosis adjustment was proposed here by developing a data-driven method. Firstly, Verbal Protocol Analysis was employed to convert the implicit process of orthosis customisation into working models of clinicians. Relevant data to inform a new solution development to reduce excessive contact pressure were extracted from the working models in terms of time consumption and iterations of tasks. Secondly, a new soft sensor skin with strategically placed sensing units to measure static contact pressures under hand orthoses was developed. Finite element simulations were conducted to reveal the required contact pressure range (0.02 – 0.078 MPa) and the distribution of relatively high pressures in 12 key areas. A new fabrication method was proposed to produce the sensor skin, which was then characterised and tested on the subject. The results show that the sensor unit has a pressure range from 0.01 MPa to 0.1 MPa with the maximum repeatability error of 6.4% at 0.014 MPa, and the maximum measurement error of 8.26% at 0.023 MPa. Thirdly, a new method was proposed to predict contact pressures associated with the moderate level of discomfort at critical spots under hand orthoses. 40 patients were recruited to collect contact pressures under two types of orthoses using the sensor skin, and their discomfort perceptions were measured with a categorical scale. Based on these data, artificial neural networks for five identified critical spots on the hand were built to predict pressure thresholds that clinicians can use to adjust orthoses, thus reducing excessive contact pressures. The neural networks show satisfactory prediction accuracy with R2 values over 0.89 of regression between network outputs and measurements. Collectively, this thesis proposed a novel method for clinicians to adjust orthoses quantitatively and reduce the need for subjective assessment for patients. It provided a platform to further investigate the pressure for patients with other conditions.Open Acces

Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and In Vitro Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time

The duration of ovarian stimulation which is largely dependent on the ovarian response to hormonal stimulation may influence in vitro fertilization (IVF) outcomes. Menstrual cycle length is potentially a good indicator of ovarian reserve and can predict ovarian response. Ovarian stimulation and the follicular phase of the menstrual cycle are both processes of follicular development. There is no published research to predict the duration of ovarian stimulation based on the length of the menstrual cycle. Our retrospective cohort study included 6110 women with regular menstrual cycles who underwent their first IVF treatment between January 2015 and October 2020. Cycles were classified according to quartiles of the ratio of ovarian stimulation duration to original follicular phase length (OS/FP). Multivariate generalized linear models were applied to assess the association between OS/FP and IVF outcomes. The odds ratio (OR) or relative risk (RR) was estimated for each quartile with the lowest quartile as the comparison group. OS/FP of 0.67 to 0.77 had more retrieved and mature oocytes (adjusted RR 1.11, 95% confidence interval [CI] 1.07–1.15, p for trend = 0.001; adjusted RR 1.14, 95% CI 1.09–1.19, p for trend = 0.001). OS/FP of 0.67 to 0.77 showed the highest rate of fertilization (adjusted OR 1.11, 95% CI 1.05–1.17, p for trend = 0.001). OS/FP > 0.77 had the lowest rate of high-quality blastocyst formation (adjusted OR 0.81, 95% CI 0.71–0.93, p for trend = 0.01). No apparent association was noted between OS/FP and clinical pregnancy, live birth, or early miscarriage rate. In conclusion, OS/FP has a significant effect on the number of oocytes, fertilization rate, and high-quality blastocyst formation rate. MCL could be used to predict the duration of ovarian stimulation with an OS/FP of 0.67 to 0.77, which provides a new indicator for the individualized clinical optimization of the trigger time

Multi-Stage Cable Routing through Hierarchical Imitation Learning

We study the problem of learning to perform multi-stage robotic manipulation tasks, with applications to cable routing, where the robot must route a cable through a series of clips. This setting presents challenges representative of complex multi-stage robotic manipulation scenarios: handling deformable objects, closing the loop on visual perception, and handling extended behaviors consisting of multiple steps that must be executed successfully to complete the entire task. In such settings, learning individual primitives for each stage that succeed with a high enough rate to perform a complete temporally extended task is impractical: if each stage must be completed successfully and has a non-negligible probability of failure, the likelihood of successful completion of the entire task becomes negligible. Therefore, successful controllers for such multi-stage tasks must be able to recover from failure and compensate for imperfections in low-level controllers by smartly choosing which controllers to trigger at any given time, retrying, or taking corrective action as needed. To this end, we describe an imitation learning system that uses vision-based policies trained from demonstrations at both the lower (motor control) and the upper (sequencing) level, present a system for instantiating this method to learn the cable routing task, and perform evaluations showing great performance in generalizing to very challenging clip placement variations. Supplementary videos, datasets, and code can be found at https://sites.google.com/view/cablerouting

Effects of calcination on mineralogical properties and reactivity of acidic aluminum sulfate residue

Acidic aluminum sulfate residue (AASR) is treated as a hazardous solid waste. However, it contains significant amounts of aluminosilicates which could be potentially utilized to produce geopolymers. The reactive activities of the aluminosilicate phases in AASR are generally low, which is a blockage of AASR-based activation to some extent. This paper aims to investigate the effect of calcination on mineralogical properties and reactivity of AASR at various temperatures ranging from 200 to 800 °C. It was demonstrated that AASR underwent substantial changes in its mineralogical, chemical, and dissolution properties after calcination. The specific surface area, pore-volume, pH, dissolution efficiency of Si and Al were increased with increasing of calcination temperature until 600 °C and then remained relatively stable at higher calcination temperatures. The results indicated that AASR is highly activated in a range of calcination temperatures between 600 and 800 °C, which verified the potential of using calcinated AASR to manufacture geopolymer products upon proper calcination process

Integrated resource strategic planning: Case study of energy efficiency in the Chinese power sector

In the last quarter of the 20th century, many power companies used the integrated resource planning (IRP) approach in power expansion planning. Today, very few power companies use this approach because of the split between the power generation and distribution activities. It seems that, in some countries, long-term power system expansion planning has become a task of the central government. To help the government in this area, this paper proposes a new approach called the integrated resource strategic planning (IRSP). When combined with a smart grid, this approach can replace the IRP for the government's power sector expansion. This paper introduces the necessity and possibility of using this new approach, presents a framework on how to use the approach, and justifies the effectiveness of this approach against the traditional power planning approach, with a case study in China. This paper concludes that if China follows the IRSP approach, it may be able to avoid or postpone up to 69 GW of power generation in the period 2009-2015. These measures could help mitigate 201.8 million tons of carbon dioxide (CO2), 0.816 million tons of sulfur dioxide (SO2), and 0.946 million tons of nitrogen oxide (NOx).Energy efficiency Integrated resource strategic planning Chinese power sector

Chronological Expression of <i>PITX2</i> and <i>SIX1</i> Genes and the Association between Their Polymorphisms and Chicken Meat Quality Traits

Meat quality is closely related to the development of skeletal muscle, in which PITX2 and SIX1 genes play important regulatory roles. The present study firstly provided the data of chronological expression files of PITX2 and SIX1 genes in the post-hatching pectoral muscle and analyzed the association of their polymorphisms with the meat quality traits of Wuliang Mountain Black-bone (WLMB) chickens. The results showed that both PITX2 and SIX1 genes were weakly expressed in the second and third weeks, and then increased significantly from the third week to the fourth week. Furthermore, there was a significant positive correlation between the expression levels of the two genes. Twelve and one SNPs were detected in the chicken PITX2 and SIX1 genes, respectively, of which four SNPs (g.9830C > T, g.10073C > T, g.13335G > A, g.13726A > G) of the PITX2 gene and one SNP (g.564G > A) of the SIX1 gene were significantly associated with chicken meat quality traits. For the PITX2 gene, chickens with the CT genotype of g.9830C > T showed the highest meat color L*, shear force (SF), pH, and the lowest electrical conductivity (EC), and drip loss (DL) (p p T had the lowest L*, pH, and the highest DL (p A had the highest (p < 0.05) SF and pH. Furthermore, pH had a significant correlation with all the other meat quality traits. The current study could contribute to the research of regulatory mechanisms of meat quality and lay the foundation for improving meat quality based on marker-assisted selection in chickens

Integrated resource strategic planning in China

Many governments around the world are focusing on emissions reduction through energy efficiency improvements, particularly on the demand side. Although Integrated Resource Planning (IRP), which considers both supply-side and demand-side options, had been a useful tool in the planning process for the power industry, its effectiveness has been challenged recently with the restructuring of the power sector that has occurred in China and elsewhere around the world. The paper proposes Integrated Resource Strategic Planning (IRSP) as an alternative to IRP in a deregulated power sector. IRSP takes the resource planning process one step further to the national level. In this paper, the authors demonstrate the tremendous potential for efficiency improvements on both the supply and demand sides of the power sector in China with IRSP. The results show that between 2009 and 2020, the potential for electricity savings will reach about 1228.5 TWh, and the potential reduction in carbon dioxide (CO2) emissions will be about 1020.5 million tons. Another important finding of this study is that the current market-based pricing system in China should be improved to provide sufficient incentives for pursuing energy savings on the demand side.IRP IRSP China

Exosomes derived from menstrual blood stromal cells ameliorated premature ovarian insufficiency and granulosa cell apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of thrombospondin-1

Premature ovarian insufficiency (POI) is clinically irreversible and seriously damages female fertility. We previously demonstrated that menstrual blood stromal cells (MenSCs)-derived exosomes (EXOs) effectively improved ovarian functions in the POI rat model. In this study, we investigated whether TSP1 is the key component in EXOs to ameliorate ovarian functions and further explored the molecular mechanism of EXOs in improving granulosa cell (GCs) activities. Our results demonstrated that knockdown TSP1 significantly debilitated the therapeutic effect of EXOs on estrous cyclicity, ovarian morphology, follicle numbers and pregnancy outcomes in 4-vinylcyclohexene diepoxide (VCD) induced POI rat model. In addition, EXOs treatment significantly promoted the activities and inhibited the apoptosis of VCD induced granulosa cells in vitro. Moreover, EXOs stimulation markedly activated the phosphorylation of SMAD3(Ser425) and AKT(Ser473), up-regulated the expressions of BCL2 and MDM2 as well as down-regulated the expressions of CASPASE3, CASPASE8, P53 and BAX. All these effects were supressed by SIS3, a inhibitor of TGF1/SMAD3. Our study revealed the key role of TSP1 in EXOs in improving POI pathology, restoring ovarian functions and GCs activities, andprovided a promising basis for EXOs in the treatment of ovarian dysfunction

Speed Breeding Scheme of Hot Pepper through Light Environment Modification

Crop breeding for high yields and quality is an important measure to ensure food security. In conventional breeding, a long generation time is required. Speed breeding could accelerate the flowering and fruiting of crops by providing suitable environmental conditions in order to reduce the generation times. This study aimed to determine a speed breeding scheme for hot peppers. Two hot pepper varieties, ‘Xiangyan 55’ and ‘Xiangla 712’, were investigated for their growth and development under different light intensities, photoperiods, and red-to-far-red ratios. Hot pepper plants bloomed at 39.88 ± 0.74 days after sowing under photosynthetic photon flux density (PPFD) 420 µmol·m−2·s−1 and a 12-h photoperiod and had seed with acceptable germination rates at 82 days after sowing. Blooming was 2–3 days earlier when the photoperiod was extended to 20 h, but the fruit and seed development were not significantly improved. Supplementation of far-red light (R:FR = 2.1) significantly accelerated the red ripening of pepper fruit and improved seed germination rates. The modification of the light environment accelerated hot pepper growth and development, reduced breeding cycles, and could produce up to four generations per year